PYRIMIDYL DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF
A pyrimidyl derivative, a preparation method therefor and the use thereof. The pyrimidyl derivative has a structure as represented by general formula (I). The pyrimidyl derivative can be used as a selective CDK7 inhibitor to address the effective treatment requirements of multiple cancers, especiall...
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| creator | WANG, Yonggang DENG, Daiguo QIU, Guanpeng LEI, Zengrong |
| description | A pyrimidyl derivative, a preparation method therefor and the use thereof. The pyrimidyl derivative has a structure as represented by general formula (I). The pyrimidyl derivative can be used as a selective CDK7 inhibitor to address the effective treatment requirements of multiple cancers, especially transcription-dysregulated cancers.
L'invention concerne un dérivé de pyrimidyle, son procédé de préparation et son utilisation. Le dérivé de pyrimidyle a une structure telle que représentée par la formule générale (I). Le dérivé de pyrimidyle peut être utilisé en tant qu'inhibiteur sélectif de CDK7 pour répondre aux exigences de traitement efficaces de cancers multiples, en particulier de cancers avec dérégulation de la transcription.
一种嘧啶基衍生物、其制备方法及其用途。所述嘧啶基衍生物具有通式(I)所示结构。该嘧啶基衍生物可以作为具有选择性的CDK7抑制剂，解决多种癌症的有效治疗需求，尤其是转录失调的癌症。 |
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L'invention concerne un dérivé de pyrimidyle, son procédé de préparation et son utilisation. Le dérivé de pyrimidyle a une structure telle que représentée par la formule générale (I). Le dérivé de pyrimidyle peut être utilisé en tant qu'inhibiteur sélectif de CDK7 pour répondre aux exigences de traitement efficaces de cancers multiples, en particulier de cancers avec dérégulation de la transcription.
一种嘧啶基衍生物、其制备方法及其用途。所述嘧啶基衍生物具有通式(I)所示结构。该嘧啶基衍生物可以作为具有选择性的CDK7抑制剂，解决多种癌症的有效治疗需求，尤其是转录失调的癌症。</description><language>chi ; eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220331&DB=EPODOC&CC=WO&NR=2022063212A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220331&DB=EPODOC&CC=WO&NR=2022063212A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WANG, Yonggang</creatorcontrib><creatorcontrib>DENG, Daiguo</creatorcontrib><creatorcontrib>QIU, Guanpeng</creatorcontrib><creatorcontrib>LEI, Zengrong</creatorcontrib><title>PYRIMIDYL DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF</title><description>A pyrimidyl derivative, a preparation method therefor and the use thereof. The pyrimidyl derivative has a structure as represented by general formula (I). The pyrimidyl derivative can be used as a selective CDK7 inhibitor to address the effective treatment requirements of multiple cancers, especially transcription-dysregulated cancers. <img file="dest_path_image002.jpg" he="53.18" img-content="drawing" img-format="jpg" inline="yes" orientation="portrait" wi="106.89"/>
L'invention concerne un dérivé de pyrimidyle, son procédé de préparation et son utilisation. Le dérivé de pyrimidyle a une structure telle que représentée par la formule générale (I). Le dérivé de pyrimidyle peut être utilisé en tant qu'inhibiteur sélectif de CDK7 pour répondre aux exigences de traitement efficaces de cancers multiples, en particulier de cancers avec dérégulation de la transcription.
一种嘧啶基衍生物、其制备方法及其用途。所述嘧啶基衍生物具有通式(I)所示结构。该嘧啶基衍生物可以作为具有选择性的CDK7抑制剂，解决多种癌症的有效治疗需求，尤其是转录失调的癌症。</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHAMiAzy9PV0ifRRcHEN8gxzDPEMc9VRCAhyDXAMAnL8_RR8XUM8_F0UQjxcg1zd_IMUHP1cFEKDXSEC_m48DKxpiTnFqbxQmptB2c01xNlDN7UgPz61uCAxOTUvtSQ-3N_IwMjIwMzYyNDI0dCYOFUAoOUr9A</recordid><startdate>20220331</startdate><enddate>20220331</enddate><creator>WANG, Yonggang</creator><creator>DENG, Daiguo</creator><creator>QIU, Guanpeng</creator><creator>LEI, Zengrong</creator><scope>EVB</scope></search><sort><creationdate>20220331</creationdate><title>PYRIMIDYL DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF</title><author>WANG, Yonggang ; DENG, Daiguo ; QIU, Guanpeng ; LEI, Zengrong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2022063212A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng ; fre</language><creationdate>2022</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>WANG, Yonggang</creatorcontrib><creatorcontrib>DENG, Daiguo</creatorcontrib><creatorcontrib>QIU, Guanpeng</creatorcontrib><creatorcontrib>LEI, Zengrong</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WANG, Yonggang</au><au>DENG, Daiguo</au><au>QIU, Guanpeng</au><au>LEI, Zengrong</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PYRIMIDYL DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF</title><date>2022-03-31</date><risdate>2022</risdate><abstract>A pyrimidyl derivative, a preparation method therefor and the use thereof. The pyrimidyl derivative has a structure as represented by general formula (I). The pyrimidyl derivative can be used as a selective CDK7 inhibitor to address the effective treatment requirements of multiple cancers, especially transcription-dysregulated cancers. <img file="dest_path_image002.jpg" he="53.18" img-content="drawing" img-format="jpg" inline="yes" orientation="portrait" wi="106.89"/>
L'invention concerne un dérivé de pyrimidyle, son procédé de préparation et son utilisation. Le dérivé de pyrimidyle a une structure telle que représentée par la formule générale (I). Le dérivé de pyrimidyle peut être utilisé en tant qu'inhibiteur sélectif de CDK7 pour répondre aux exigences de traitement efficaces de cancers multiples, en particulier de cancers avec dérégulation de la transcription.
一种嘧啶基衍生物、其制备方法及其用途。所述嘧啶基衍生物具有通式(I)所示结构。该嘧啶基衍生物可以作为具有选择性的CDK7抑制剂，解决多种癌症的有效治疗需求，尤其是转录失调的癌症。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PYRIMIDYL DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF |
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