COMPOSITIONS AND METHODS FOR TCR REPROGRAMMING USING NECTIN-4 SPECIFIC FUSION PROTEINS

Provided herein are T cell receptor (TCR) fusion proteins (TFPs) comprising Nectin-4 binding domains, T cells engineered to express one or more TFPs, and methods of use thereof for the treatment of diseases, including cancer. La présente invention concerne des protéines de fusion (TFP) du récepteur...

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Hauptverfasser:	MIRZABEKOV, Marat, ASHMINOVA, Vania, LOFGREN, Michael, TIGHE, Robert, HOFMEISTER, Robert, GUTIERREZ, Dario, HANES, Melinda, COLLARD, Andrew
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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