PRODUCTION OF HYDROXYLATED POLYUNSATURATED FATTY ACIDS

A method for producing and purifying hydroxylated polyunsaturated fatty acid (PUFA) derivatives is provided. The method includes reacting a PUFA, preferably eicosapentaenoic acid (EPA) and an enzyme, preferably a P450 enzyme, followed by purification via filtration and/orextraction and/or chromatogr...

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Bibliographische Detailangaben
Hauptverfasser:	SCHÜRMANN, Martin, MUGFORD, Paul Frederick, QUAEDFLIEG, Peter Jan Leonard Mario
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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Beschreibung
Zusammenfassung:	A method for producing and purifying hydroxylated polyunsaturated fatty acid (PUFA) derivatives is provided. The method includes reacting a PUFA, preferably eicosapentaenoic acid (EPA) and an enzyme, preferably a P450 enzyme, followed by purification via filtration and/orextraction and/or chromatography. Use of the resulting hydroxylated PUFA derivative, preferably 18-hydroxyeicosapentaenoic acid (18-HEPE) in medicines or food applications, preferably in infant food and/or formula is also provided. L'invention concerne un procédé de production et de purification de dérivés d'acides gras polyinsaturés (AGPI) hydroxylés. Le procédé consiste à faire réagir un AGPI, de préférence l'acide elcosapentaénoïque, avec une enzyme, de préférence une enzyme P450, puis à réaliser une purification par filtration et/ou extraction et/ou chromatographie. L'invention concerne également l'utilisation du dérivé d'AGPI hydroxylé obtenu, de préférence l'acide 18-hydroxyeicosapentaénoïque (18-HEPE), dans des médicaments ou des applications alimentaires, de préférence dans des aliments et/ou une formule pour nourrissons.