COMPOSITION FOR PROMOTING DIFFERENTIATION OF NEURAL STEM CELLS INTO DOPAMINERGIC NEURONS

The present invention relates to a composition and method for promoting the differentiation of neural stem cells into dopaminergic neurons, the composition including fusaric acid, ascorbic acid, nicotinamide adenine dinucleotide, or a combination thereof. The composition and method according to an aspect not only increase the differentiation of neural stem cells, isolated in an initial stage of development, into dopaminergic neurons, but also increase the differentiation of subcultured neural stem cells into dopaminergic neurons, thus making it possible to secure more dopaminergic neurons and therefore increase therapeutic effects on Parkinson's disease. La présente invention concerne une composition et un procédé pour favoriser la différenciation de cellules souches neurales en neurones dopaminergiques, la composition comprenant de l'acide fusarique, de l'acide ascorbique, du nicotinamide adénine dinucléotide, ou une combinaison de ceux-ci. La composition et le procédé selon un aspect augmentent non seulement la différenciation des cellules souches neurales, isolées à un stade initial de développement, en neurones dopaminergiques, mais augmentent également la différenciation des cellules souches neurales sous-cultivées en neurones dopaminergiques, permettant ainsi d'obtenir davantage de neurones dopaminergiques et donc d'augmenter les effets thérapeutiques sur la maladie de Parkinson. 퓨사린산, 아스코르브산, 니코틴아마이드 아데닌 디뉴클레오티드, 또는 이들의 조합을 포함하는 신경줄기세포의 도파민 신경세포로의 분화를 촉진하는 조성물 및 방법에 관한 것이다. 일 양상에 따른 조성물 및 방법은 발생 초기 단계에서 분리된 신경줄기세포의 도파민 신경세포로의 분화를 증가시킬 뿐만 아니라, 계대 배양을 거친 신경줄기세포의 도파민 신경세포로의 분화를 증가시켜, 보다 많은 도파민 신경세포의 확보가 가능하므로, 파킨슨병의 치료 효과를 높일 수 있다.