STABLE FORMULATIONS COMPRISING THIOTEPA
The present disclosure provides pharmaceutical compositions comprising thiotepa, water, one selected from PEG, such as PEG400 or PEG600, and DMSO, and optionally thiosulfate. Also provided is a method for treating cancer in a subject, or myeloablation prior to bone marrow transplantation using the c...
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| creator | RYAN, Orlaith CUNNINGHAM, Sharon PLATTEEUW, Johannes Jan |
| description | The present disclosure provides pharmaceutical compositions comprising thiotepa, water, one selected from PEG, such as PEG400 or PEG600, and DMSO, and optionally thiosulfate. Also provided is a method for treating cancer in a subject, or myeloablation prior to bone marrow transplantation using the composition. A method for enhancing the stability of a thiotepa formulation is also contemplated.
La présente invention concerne des compositions pharmaceutiques comprenant du thiotépa, de l'eau, un composant sélectionné entre le PEG, tel que le PEG400 ou le PEG600, et le DMSO, et facultativement du thiosulfate. L'invention concerne également une méthode destinée à traiter le cancer chez un individu, ou à être utilisée dans la myéloablation avant greffe de moelle osseuse, au moyen de ladite composition. L'invention concerne également une méthode destinée à améliorer la stabilité d'une formulation de thiotépa. |
| format | Patent |
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La présente invention concerne des compositions pharmaceutiques comprenant du thiotépa, de l'eau, un composant sélectionné entre le PEG, tel que le PEG400 ou le PEG600, et le DMSO, et facultativement du thiosulfate. L'invention concerne également une méthode destinée à traiter le cancer chez un individu, ou à être utilisée dans la myéloablation avant greffe de moelle osseuse, au moyen de ladite composition. L'invention concerne également une méthode destinée à améliorer la stabilité d'une formulation de thiotépa.</description><language>eng ; fre</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220224&DB=EPODOC&CC=WO&NR=2022038490A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220224&DB=EPODOC&CC=WO&NR=2022038490A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RYAN, Orlaith</creatorcontrib><creatorcontrib>CUNNINGHAM, Sharon</creatorcontrib><creatorcontrib>PLATTEEUW, Johannes Jan</creatorcontrib><title>STABLE FORMULATIONS COMPRISING THIOTEPA</title><description>The present disclosure provides pharmaceutical compositions comprising thiotepa, water, one selected from PEG, such as PEG400 or PEG600, and DMSO, and optionally thiosulfate. Also provided is a method for treating cancer in a subject, or myeloablation prior to bone marrow transplantation using the composition. A method for enhancing the stability of a thiotepa formulation is also contemplated.
La présente invention concerne des compositions pharmaceutiques comprenant du thiotépa, de l'eau, un composant sélectionné entre le PEG, tel que le PEG400 ou le PEG600, et le DMSO, et facultativement du thiosulfate. L'invention concerne également une méthode destinée à traiter le cancer chez un individu, ou à être utilisée dans la myéloablation avant greffe de moelle osseuse, au moyen de ladite composition. L'invention concerne également une méthode destinée à améliorer la stabilité d'une formulation de thiotépa.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFAPDnF08nFVcPMP8g31cQzx9PcLVnD29w0I8gz29HNXCPHw9A9xDXDkYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXx4f5GBkZGBsYWJpYGjobGxKkCAJo1JRE</recordid><startdate>20220224</startdate><enddate>20220224</enddate><creator>RYAN, Orlaith</creator><creator>CUNNINGHAM, Sharon</creator><creator>PLATTEEUW, Johannes Jan</creator><scope>EVB</scope></search><sort><creationdate>20220224</creationdate><title>STABLE FORMULATIONS COMPRISING THIOTEPA</title><author>RYAN, Orlaith ; CUNNINGHAM, Sharon ; PLATTEEUW, Johannes Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2022038490A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2022</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>RYAN, Orlaith</creatorcontrib><creatorcontrib>CUNNINGHAM, Sharon</creatorcontrib><creatorcontrib>PLATTEEUW, Johannes Jan</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>RYAN, Orlaith</au><au>CUNNINGHAM, Sharon</au><au>PLATTEEUW, Johannes Jan</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>STABLE FORMULATIONS COMPRISING THIOTEPA</title><date>2022-02-24</date><risdate>2022</risdate><abstract>The present disclosure provides pharmaceutical compositions comprising thiotepa, water, one selected from PEG, such as PEG400 or PEG600, and DMSO, and optionally thiosulfate. Also provided is a method for treating cancer in a subject, or myeloablation prior to bone marrow transplantation using the composition. A method for enhancing the stability of a thiotepa formulation is also contemplated.
La présente invention concerne des compositions pharmaceutiques comprenant du thiotépa, de l'eau, un composant sélectionné entre le PEG, tel que le PEG400 ou le PEG600, et le DMSO, et facultativement du thiosulfate. L'invention concerne également une méthode destinée à traiter le cancer chez un individu, ou à être utilisée dans la myéloablation avant greffe de moelle osseuse, au moyen de ladite composition. L'invention concerne également une méthode destinée à améliorer la stabilité d'une formulation de thiotépa.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | STABLE FORMULATIONS COMPRISING THIOTEPA |
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