GASTRO-RESISTANT HIGH-STRENGTH FORMULATION CONTAINING POSACONAZOLE

The present invention relates to a gastro-resistant high-strength unit dosage form comprising a solid solution prepared by hot-melt extrusion, whereby the solid solution contains 300 mg posaconazole and an enteric polymer in a specific weight ratio. The unit dosage form may be a capsule or optionall...

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Hauptverfasser: PRATHAP, Vamshi Ramana, FITZNER, Ansgar, SCHLEHAHN, Hendrik, RALLABANDI, Bala Ramesha Chary, MUPKALKER, Ashwini Kumar, VELCHURI, Srikanth, KALAMATA, Venkatasimhadri Naidu, MADALLAPALLI, Kiran Kumar
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creator PRATHAP, Vamshi Ramana
FITZNER, Ansgar
SCHLEHAHN, Hendrik
RALLABANDI, Bala Ramesha Chary
MUPKALKER, Ashwini Kumar
VELCHURI, Srikanth
KALAMATA, Venkatasimhadri Naidu
MADALLAPALLI, Kiran Kumar
description The present invention relates to a gastro-resistant high-strength unit dosage form comprising a solid solution prepared by hot-melt extrusion, whereby the solid solution contains 300 mg posaconazole and an enteric polymer in a specific weight ratio. The unit dosage form may be a capsule or optionally film-coated tablet. La présente invention concerne une forme galénique unitaire à haute résistance entérosoluble comprenant une solution solide préparée par extrusion à chaud, la solution solide contenant 300 mg de posaconazole et un polymère entérique dans un rapport pondéral spécifique. La forme galénique unitaire peut être une capsule ou un comprimé éventuellement enrobé d'un film.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title GASTRO-RESISTANT HIGH-STRENGTH FORMULATION CONTAINING POSACONAZOLE
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