S100 PROTEINS AS NOVEL THERAPEUTIC TARGETS IN MYELOPROLIFERATIVE NEOPLASMS

The current invention pertains an inhibitor of an S100 protein, preferably an inhibitor of an S100A8 or S100A9 protein, for the prevention or treatment of a myeloproliferative neoplasm. In particular, the invention pertains to an inhibitor of an S100A8 orS100A9 protein, for the prevention ortreatmen...

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1. Verfasser: SCHNEIDER-KRAMANN, Rebekka Katharina Marita
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description The current invention pertains an inhibitor of an S100 protein, preferably an inhibitor of an S100A8 or S100A9 protein, for the prevention or treatment of a myeloproliferative neoplasm. In particular, the invention pertains to an inhibitor of an S100A8 orS100A9 protein, for the prevention ortreatment of primary myelofibrosis. The invention further pertains to an diagnostic method for identifying a subject suffering from a myeloproliferative neoplasm, comprising a step of detecting the presence of an S100 protein, preferably S100A8 or S100A9, in a biological sample. La présente invention concerne un inhibiteur d'une protéine S100, de préférence un inhibiteur d'une protéine S100A8 ou S100A9, destiné à la prévention ou au traitement d'une tumeur myéloproliférative. En particulier, l'invention concerne un inhibiteur d'une protéine S100A8 ou S100A9, destiné à la prévention ou au traitement de la myélofibrose primitive. L'invention concerne en outre une méthode de diagnostic permettant d'identifier un sujet souffrant d'une tumeur myéloproliférative, comprenant une étape de détection de la présence d'une protéine S100, de préférence S100A8 ou S100A9, dans un échantillon biologique.
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title S100 PROTEINS AS NOVEL THERAPEUTIC TARGETS IN MYELOPROLIFERATIVE NEOPLASMS
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