COMPOUNDS USEFUL AS FACTOR XIA INHIBITORS

The present invention is directed to Factor XIa inhibitors, tautomers, stereoisomers, isotopologues, and pharmaceutically acceptable salts and solvates thereof, pharmaceutical compositions containing said compounds and the use of said compounds in the treatment and / or prophylaxis of thromboembolic...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	NARGUND, Ravi, MACIELAG, Mark J, LIU, Zhijie, XU, Guozhang, THIEU, Tho V
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention is directed to Factor XIa inhibitors, tautomers, stereoisomers, isotopologues, and pharmaceutically acceptable salts and solvates thereof, pharmaceutical compositions containing said compounds and the use of said compounds in the treatment and / or prophylaxis of thromboembolic disorders, inflammatory disorders, and diseases or conditions in which plasma kallikrein activity is implicated. La présente invention concerne des inhibiteurs du facteur XIa, des tautomères, des stéréoisomères, des isotopologues, et des sels et des solvates pharmaceutiquement acceptables de ceux-ci, des compositions pharmaceutiques contenant lesdits composés et l'utilisation desdits composés dans le traitement et/ou dans la prophylaxie de troubles thromboemboliques, de troubles inflammatoires et de maladies ou d'états dans lesquels l'activité de la kallicréine plasmatique joue un rôle.