IL-10 MUTEINS AND FUSION PROTEINS THEREOF
The present disclosure relates, in general, to muteins of IL-10 that are stable as monomers, antigen binding proteins that bind to TREM-1, and antigen binding proteins comprising IL-10 muteins and antigen binding moieties, e.g., anti-TREM-1 antibodies, and compositions thereof. The disclosure also p...
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| creator | LUNA, Victor Mitch CAMDERE TAPIA, Gamze Ozlem WANNBERG, Sharon FOLTZ, Ian MOCK, Marissa RILEY, Timothy P ZHANG, Ming HSU, Hailing |
| description | The present disclosure relates, in general, to muteins of IL-10 that are stable as monomers, antigen binding proteins that bind to TREM-1, and antigen binding proteins comprising IL-10 muteins and antigen binding moieties, e.g., anti-TREM-1 antibodies, and compositions thereof. The disclosure also provides methods of treating inflammatory disease, such as inflammatory bowel disease or ulcerative colitis, using the compositions.
La présente invention concerne, en général, des mutéines d'IL-10 qui sont stables en tant que monomères, des protéines de liaison à l'antigène qui se lient à TREM-1, et des protéines de liaison à l'antigène comprenant des mutéines d'IL-10 et des fractions de liaison à l'antigène, par exemple des anticorps anti-TREM-1, et des compositions de celles-ci. L'invention concerne également des procédés de traitement d'une maladie inflammatoire, telle qu'une maladie intestinale inflammatoire ou une colite ulcéreuse, à l'aide de ces compositions. |
| format | Patent |
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La présente invention concerne, en général, des mutéines d'IL-10 qui sont stables en tant que monomères, des protéines de liaison à l'antigène qui se lient à TREM-1, et des protéines de liaison à l'antigène comprenant des mutéines d'IL-10 et des fractions de liaison à l'antigène, par exemple des anticorps anti-TREM-1, et des compositions de celles-ci. L'invention concerne également des procédés de traitement d'une maladie inflammatoire, telle qu'une maladie intestinale inflammatoire ou une colite ulcéreuse, à l'aide de ces compositions.</description><language>eng ; fre</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211230&DB=EPODOC&CC=WO&NR=2021263167A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211230&DB=EPODOC&CC=WO&NR=2021263167A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LUNA, Victor Mitch</creatorcontrib><creatorcontrib>CAMDERE TAPIA, Gamze Ozlem</creatorcontrib><creatorcontrib>WANNBERG, Sharon</creatorcontrib><creatorcontrib>FOLTZ, Ian</creatorcontrib><creatorcontrib>MOCK, Marissa</creatorcontrib><creatorcontrib>RILEY, Timothy P</creatorcontrib><creatorcontrib>ZHANG, Ming</creatorcontrib><creatorcontrib>HSU, Hailing</creatorcontrib><title>IL-10 MUTEINS AND FUSION PROTEINS THEREOF</title><description>The present disclosure relates, in general, to muteins of IL-10 that are stable as monomers, antigen binding proteins that bind to TREM-1, and antigen binding proteins comprising IL-10 muteins and antigen binding moieties, e.g., anti-TREM-1 antibodies, and compositions thereof. The disclosure also provides methods of treating inflammatory disease, such as inflammatory bowel disease or ulcerative colitis, using the compositions.
La présente invention concerne, en général, des mutéines d'IL-10 qui sont stables en tant que monomères, des protéines de liaison à l'antigène qui se lient à TREM-1, et des protéines de liaison à l'antigène comprenant des mutéines d'IL-10 et des fractions de liaison à l'antigène, par exemple des anticorps anti-TREM-1, et des compositions de celles-ci. L'invention concerne également des procédés de traitement d'une maladie inflammatoire, telle qu'une maladie intestinale inflammatoire ou une colite ulcéreuse, à l'aide de ces compositions.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZND09NE1NFDwDQ1x9fQLVnD0c1FwCw329PdTCAjyh4iFeLgGufq78TCwpiXmFKfyQmluBmU31xBnD93Ugvz41OKCxOTUvNSS-HB_IwMjQyMzY0Mzc0cjY-JUAQCdLyUO</recordid><startdate>20211230</startdate><enddate>20211230</enddate><creator>LUNA, Victor Mitch</creator><creator>CAMDERE TAPIA, Gamze Ozlem</creator><creator>WANNBERG, Sharon</creator><creator>FOLTZ, Ian</creator><creator>MOCK, Marissa</creator><creator>RILEY, Timothy P</creator><creator>ZHANG, Ming</creator><creator>HSU, Hailing</creator><scope>EVB</scope></search><sort><creationdate>20211230</creationdate><title>IL-10 MUTEINS AND FUSION PROTEINS THEREOF</title><author>LUNA, Victor Mitch ; CAMDERE TAPIA, Gamze Ozlem ; WANNBERG, Sharon ; FOLTZ, Ian ; MOCK, Marissa ; RILEY, Timothy P ; ZHANG, Ming ; HSU, Hailing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2021263167A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2021</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>LUNA, Victor Mitch</creatorcontrib><creatorcontrib>CAMDERE TAPIA, Gamze Ozlem</creatorcontrib><creatorcontrib>WANNBERG, Sharon</creatorcontrib><creatorcontrib>FOLTZ, Ian</creatorcontrib><creatorcontrib>MOCK, Marissa</creatorcontrib><creatorcontrib>RILEY, Timothy P</creatorcontrib><creatorcontrib>ZHANG, Ming</creatorcontrib><creatorcontrib>HSU, Hailing</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LUNA, Victor Mitch</au><au>CAMDERE TAPIA, Gamze Ozlem</au><au>WANNBERG, Sharon</au><au>FOLTZ, Ian</au><au>MOCK, Marissa</au><au>RILEY, Timothy P</au><au>ZHANG, Ming</au><au>HSU, Hailing</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>IL-10 MUTEINS AND FUSION PROTEINS THEREOF</title><date>2021-12-30</date><risdate>2021</risdate><abstract>The present disclosure relates, in general, to muteins of IL-10 that are stable as monomers, antigen binding proteins that bind to TREM-1, and antigen binding proteins comprising IL-10 muteins and antigen binding moieties, e.g., anti-TREM-1 antibodies, and compositions thereof. The disclosure also provides methods of treating inflammatory disease, such as inflammatory bowel disease or ulcerative colitis, using the compositions.
La présente invention concerne, en général, des mutéines d'IL-10 qui sont stables en tant que monomères, des protéines de liaison à l'antigène qui se lient à TREM-1, et des protéines de liaison à l'antigène comprenant des mutéines d'IL-10 et des fractions de liaison à l'antigène, par exemple des anticorps anti-TREM-1, et des compositions de celles-ci. L'invention concerne également des procédés de traitement d'une maladie inflammatoire, telle qu'une maladie intestinale inflammatoire ou une colite ulcéreuse, à l'aide de ces compositions.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | IL-10 MUTEINS AND FUSION PROTEINS THEREOF |
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