SYNTHETIC METHODS FOR PREPARATION OF 4-(2-CHLORO-4-METHOXY-5- METHYLPHENYL)-V-[(LS)-2-CYCLOPROPYL-L-(3-FLUORO-4-METHYLPHENYL)ETHYL]-5-METHYL-V-PROP-2-YNYL-L,3-THIAZOL-2-AMINE
The present disclosure relates to the fields of chemistry and medicine, more particularly to processes for making 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2 -cyclopropyl-1-(3 -fluoro-4-methylphenyl)ethyl]-5-methyl-N-prop-2-ynyl-1,3-thiazol-2-amine (Compound 1), pharmaceutically acceptable salts...
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| creator | RADISSON, Joel PALMER, Andrew STIRN, Scott |
| description | The present disclosure relates to the fields of chemistry and medicine, more particularly to processes for making 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2 -cyclopropyl-1-(3 -fluoro-4-methylphenyl)ethyl]-5-methyl-N-prop-2-ynyl-1,3-thiazol-2-amine (Compound 1), pharmaceutically acceptable salts, and crystalline forms thereof, for the treatment of congenital adrenal hyperplasia (CAH).
La présente invention concerne les domaines de la chimie et de la médecine, et plus particulièrement des procédés de fabrication de 4-(2-chloro-4-méthoxy-5-méthylphényl)-N-[(1S)-2 -cyclopropyl-1-(3 -fluoro-4-méthylphényl)éthyl]-5-méthyl-N-prop-2-ynyl-1,3-thiazol-2-amine (composé 1), des sels pharmaceutiquement acceptables et des formes cristallines de ceux-ci, pour le traitement le l'hyperplasie congénitale des surrénales (HCS). |
| format | Patent |
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La présente invention concerne les domaines de la chimie et de la médecine, et plus particulièrement des procédés de fabrication de 4-(2-chloro-4-méthoxy-5-méthylphényl)-N-[(1S)-2 -cyclopropyl-1-(3 -fluoro-4-méthylphényl)éthyl]-5-méthyl-N-prop-2-ynyl-1,3-thiazol-2-amine (composé 1), des sels pharmaceutiquement acceptables et des formes cristallines de ceux-ci, pour le traitement le l'hyperplasie congénitale des surrénales (HCS).</description><language>eng ; fre</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220120&DB=EPODOC&CC=WO&NR=2021250468A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220120&DB=EPODOC&CC=WO&NR=2021250468A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RADISSON, Joel</creatorcontrib><creatorcontrib>PALMER, Andrew</creatorcontrib><creatorcontrib>STIRN, Scott</creatorcontrib><title>SYNTHETIC METHODS FOR PREPARATION OF 4-(2-CHLORO-4-METHOXY-5- METHYLPHENYL)-V-[(LS)-2-CYCLOPROPYL-L-(3-FLUORO-4-METHYLPHENYL)ETHYL]-5-METHYL-V-PROP-2-YNYL-L,3-THIAZOL-2-AMINE</title><description>The present disclosure relates to the fields of chemistry and medicine, more particularly to processes for making 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2 -cyclopropyl-1-(3 -fluoro-4-methylphenyl)ethyl]-5-methyl-N-prop-2-ynyl-1,3-thiazol-2-amine (Compound 1), pharmaceutically acceptable salts, and crystalline forms thereof, for the treatment of congenital adrenal hyperplasia (CAH).
La présente invention concerne les domaines de la chimie et de la médecine, et plus particulièrement des procédés de fabrication de 4-(2-chloro-4-méthoxy-5-méthylphényl)-N-[(1S)-2 -cyclopropyl-1-(3 -fluoro-4-méthylphényl)éthyl]-5-méthyl-N-prop-2-ynyl-1,3-thiazol-2-amine (composé 1), des sels pharmaceutiquement acceptables et des formes cristallines de ceux-ci, pour le traitement le l'hyperplasie congénitale des surrénales (HCS).</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNzE0KwjAQBeBuXIh6h4CbCg5oW8VtqCkpjJmQxp8oIiJxJSrouTyjsYpuXc3weN9rRo_KKSuFLXM2E1bStGIFGaaN0NxwW5JiVLAM4gRyiWQIMqiLKwcjqI1DLYVy2IMFbGKsehC6LkfShrRDQIhTKHD-w19R_9sw9E7DwMsE79QL9lOwsuRrwhDxWalEO2oc96eb73xuK-oWwuYS_PWy87fr_uDP_r5bUjJIhslokI0nPE3_az0BCdlJBQ</recordid><startdate>20220120</startdate><enddate>20220120</enddate><creator>RADISSON, Joel</creator><creator>PALMER, Andrew</creator><creator>STIRN, Scott</creator><scope>EVB</scope></search><sort><creationdate>20220120</creationdate><title>SYNTHETIC METHODS FOR PREPARATION OF 4-(2-CHLORO-4-METHOXY-5- METHYLPHENYL)-V-[(LS)-2-CYCLOPROPYL-L-(3-FLUORO-4-METHYLPHENYL)ETHYL]-5-METHYL-V-PROP-2-YNYL-L,3-THIAZOL-2-AMINE</title><author>RADISSON, Joel ; PALMER, Andrew ; STIRN, Scott</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2021250468A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2022</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>RADISSON, Joel</creatorcontrib><creatorcontrib>PALMER, Andrew</creatorcontrib><creatorcontrib>STIRN, Scott</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>RADISSON, Joel</au><au>PALMER, Andrew</au><au>STIRN, Scott</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SYNTHETIC METHODS FOR PREPARATION OF 4-(2-CHLORO-4-METHOXY-5- METHYLPHENYL)-V-[(LS)-2-CYCLOPROPYL-L-(3-FLUORO-4-METHYLPHENYL)ETHYL]-5-METHYL-V-PROP-2-YNYL-L,3-THIAZOL-2-AMINE</title><date>2022-01-20</date><risdate>2022</risdate><abstract>The present disclosure relates to the fields of chemistry and medicine, more particularly to processes for making 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2 -cyclopropyl-1-(3 -fluoro-4-methylphenyl)ethyl]-5-methyl-N-prop-2-ynyl-1,3-thiazol-2-amine (Compound 1), pharmaceutically acceptable salts, and crystalline forms thereof, for the treatment of congenital adrenal hyperplasia (CAH).
La présente invention concerne les domaines de la chimie et de la médecine, et plus particulièrement des procédés de fabrication de 4-(2-chloro-4-méthoxy-5-méthylphényl)-N-[(1S)-2 -cyclopropyl-1-(3 -fluoro-4-méthylphényl)éthyl]-5-méthyl-N-prop-2-ynyl-1,3-thiazol-2-amine (composé 1), des sels pharmaceutiquement acceptables et des formes cristallines de ceux-ci, pour le traitement le l'hyperplasie congénitale des surrénales (HCS).</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | SYNTHETIC METHODS FOR PREPARATION OF 4-(2-CHLORO-4-METHOXY-5- METHYLPHENYL)-V-[(LS)-2-CYCLOPROPYL-L-(3-FLUORO-4-METHYLPHENYL)ETHYL]-5-METHYL-V-PROP-2-YNYL-L,3-THIAZOL-2-AMINE |
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