RNAI CONSTRUCTS FOR INHIBITING HSD17B13 EXPRESSION AND METHODS OF USE THEREOF

The present invention relates to RNAi constructs for reducing expression of the HSD17B13 gene. Methods of using such RNAi constructs to treat or prevent liver disease, nonalcoholic fatty liver disease (NAFLD) are also described. La présente invention concerne des constructions d'ARNi permettant...

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Bibliographische Detailangaben
Hauptverfasser:	HOMANN, Oliver, MURRAY, Justin K, HERBERICH, Bradley J, COLLINS, Patrick, DAS, Amrita, LIN, Daniel C. H, OLLMANN, Michael
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to RNAi constructs for reducing expression of the HSD17B13 gene. Methods of using such RNAi constructs to treat or prevent liver disease, nonalcoholic fatty liver disease (NAFLD) are also described. La présente invention concerne des constructions d'ARNi permettant de réduire l'expression du gène HSD17B13. L'invention concerne également des procédés d'utilisation de ces constructions d'ARNi pour traiter ou prévenir une maladie hépatique etune stéatose hépatique non alcoolique (NAFLD).