CORONAVIRUS RNA REPLICONS AND USE THEREOF AS VACCINES
Disclosed is an RNA replicon derived from a coronavirus having completely or partly deleted therefrom: the gene encoding the protein E and at least four genes encoding genus accessory proteins selected from: 3, 4a, 4b and 5, in the case of MERS-CoV. A method for preparing same and the use thereof in...
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| creator | SOLA GURPEGUI, María Isabel ENJUANES SÁNCHEZ, Luis ZÚÑIGA LUCAS, Sonia GUTIÉRREZ ÁLVAREZ, Francisco Javier HONRUBIA BELENGUER, José Manuel FERNÁNDEZ DELGADO, Raúl |
| description | Disclosed is an RNA replicon derived from a coronavirus having completely or partly deleted therefrom: the gene encoding the protein E and at least four genes encoding genus accessory proteins selected from: 3, 4a, 4b and 5, in the case of MERS-CoV. A method for preparing same and the use thereof in vaccine compositions is also disclosed.
Replicón de ARN derivado un coronavirus al que se ha delecionado total o parcialmente: el gen que codifica la proteína E y al menos 4 genes que codifican proteínas accesorias de género seleccionados entre: 3, 4a, 4b y 5, en el caso de MERS-CoV. Método de preparación del mismo, y su uso en composiciones vacunales.
L'invention concerne un réplicon d'ARN dérivé d'un coronavirus auquel on a ôté une partie ou la totalité : du gène qui codifie la protéine E et au moins 4 gènes qui codifient des protéines accessoires du type sélectionnés parmi: 3, 4a, 4b et 5, dans le cas de MERS-CoV. L'invention concerne également un procédé de préparation de celui-ci, et son utilisation dans des compositions vaccinales. |
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Replicón de ARN derivado un coronavirus al que se ha delecionado total o parcialmente: el gen que codifica la proteína E y al menos 4 genes que codifican proteínas accesorias de género seleccionados entre: 3, 4a, 4b y 5, en el caso de MERS-CoV. Método de preparación del mismo, y su uso en composiciones vacunales.
L'invention concerne un réplicon d'ARN dérivé d'un coronavirus auquel on a ôté une partie ou la totalité : du gène qui codifie la protéine E et au moins 4 gènes qui codifient des protéines accessoires du type sélectionnés parmi: 3, 4a, 4b et 5, dans le cas de MERS-CoV. L'invention concerne également un procédé de préparation de celui-ci, et son utilisation dans des compositions vaccinales.</description><language>eng ; fre ; spa</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211202&DB=EPODOC&CC=WO&NR=2021240039A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211202&DB=EPODOC&CC=WO&NR=2021240039A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SOLA GURPEGUI, María Isabel</creatorcontrib><creatorcontrib>ENJUANES SÁNCHEZ, Luis</creatorcontrib><creatorcontrib>ZÚÑIGA LUCAS, Sonia</creatorcontrib><creatorcontrib>GUTIÉRREZ ÁLVAREZ, Francisco Javier</creatorcontrib><creatorcontrib>HONRUBIA BELENGUER, José Manuel</creatorcontrib><creatorcontrib>FERNÁNDEZ DELGADO, Raúl</creatorcontrib><title>CORONAVIRUS RNA REPLICONS AND USE THEREOF AS VACCINES</title><description>Disclosed is an RNA replicon derived from a coronavirus having completely or partly deleted therefrom: the gene encoding the protein E and at least four genes encoding genus accessory proteins selected from: 3, 4a, 4b and 5, in the case of MERS-CoV. A method for preparing same and the use thereof in vaccine compositions is also disclosed.
Replicón de ARN derivado un coronavirus al que se ha delecionado total o parcialmente: el gen que codifica la proteína E y al menos 4 genes que codifican proteínas accesorias de género seleccionados entre: 3, 4a, 4b y 5, en el caso de MERS-CoV. Método de preparación del mismo, y su uso en composiciones vacunales.
L'invention concerne un réplicon d'ARN dérivé d'un coronavirus auquel on a ôté une partie ou la totalité : du gène qui codifie la protéine E et au moins 4 gènes qui codifient des protéines accessoires du type sélectionnés parmi: 3, 4a, 4b et 5, dans le cas de MERS-CoV. L'invention concerne également un procédé de préparation de celui-ci, et son utilisation dans des compositions vaccinales.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDB19g_y93MM8wwKDVYI8nNUCHIN8PF09vcLVnD0c1EIDXZVCPFwDXL1d1NwDFYIc3R29vRzDeZhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfHh_kYGRoZGJgYGxpaOhsbEqQIAihAocg</recordid><startdate>20211202</startdate><enddate>20211202</enddate><creator>SOLA GURPEGUI, María Isabel</creator><creator>ENJUANES SÁNCHEZ, Luis</creator><creator>ZÚÑIGA LUCAS, Sonia</creator><creator>GUTIÉRREZ ÁLVAREZ, Francisco Javier</creator><creator>HONRUBIA BELENGUER, José Manuel</creator><creator>FERNÁNDEZ DELGADO, Raúl</creator><scope>EVB</scope></search><sort><creationdate>20211202</creationdate><title>CORONAVIRUS RNA REPLICONS AND USE THEREOF AS VACCINES</title><author>SOLA GURPEGUI, María Isabel ; ENJUANES SÁNCHEZ, Luis ; ZÚÑIGA LUCAS, Sonia ; GUTIÉRREZ ÁLVAREZ, Francisco Javier ; HONRUBIA BELENGUER, José Manuel ; FERNÁNDEZ DELGADO, Raúl</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2021240039A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; spa</language><creationdate>2021</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>SOLA GURPEGUI, María Isabel</creatorcontrib><creatorcontrib>ENJUANES SÁNCHEZ, Luis</creatorcontrib><creatorcontrib>ZÚÑIGA LUCAS, Sonia</creatorcontrib><creatorcontrib>GUTIÉRREZ ÁLVAREZ, Francisco Javier</creatorcontrib><creatorcontrib>HONRUBIA BELENGUER, José Manuel</creatorcontrib><creatorcontrib>FERNÁNDEZ DELGADO, Raúl</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SOLA GURPEGUI, María Isabel</au><au>ENJUANES SÁNCHEZ, Luis</au><au>ZÚÑIGA LUCAS, Sonia</au><au>GUTIÉRREZ ÁLVAREZ, Francisco Javier</au><au>HONRUBIA BELENGUER, José Manuel</au><au>FERNÁNDEZ DELGADO, Raúl</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CORONAVIRUS RNA REPLICONS AND USE THEREOF AS VACCINES</title><date>2021-12-02</date><risdate>2021</risdate><abstract>Disclosed is an RNA replicon derived from a coronavirus having completely or partly deleted therefrom: the gene encoding the protein E and at least four genes encoding genus accessory proteins selected from: 3, 4a, 4b and 5, in the case of MERS-CoV. A method for preparing same and the use thereof in vaccine compositions is also disclosed.
Replicón de ARN derivado un coronavirus al que se ha delecionado total o parcialmente: el gen que codifica la proteína E y al menos 4 genes que codifican proteínas accesorias de género seleccionados entre: 3, 4a, 4b y 5, en el caso de MERS-CoV. Método de preparación del mismo, y su uso en composiciones vacunales.
L'invention concerne un réplicon d'ARN dérivé d'un coronavirus auquel on a ôté une partie ou la totalité : du gène qui codifie la protéine E et au moins 4 gènes qui codifient des protéines accessoires du type sélectionnés parmi: 3, 4a, 4b et 5, dans le cas de MERS-CoV. L'invention concerne également un procédé de préparation de celui-ci, et son utilisation dans des compositions vaccinales.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | CORONAVIRUS RNA REPLICONS AND USE THEREOF AS VACCINES |
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