SYNTHESIS OF FLUORINATED NUCLEOTIDES
The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (2S,3R,4S,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-fluoro-4-hydroxy-2-(mercaptomethyl)tetrahydrofuran-3-yl dihydrogen phosphate, also known as 3´-fluoro-thio-guanosine monophos...
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| creator | TURNBULL, Ben William Hulme XU, Feng ARMIGER, Travis BENKOVICS, Tamas MOORE, Jeffrey SONG, Zhiguo Jake PENG, Feng KLAPARS, Artis SHERRY, Benjamin BELYK, Kevin RUMMELT, Stephan CHUNG, Cheol LIU, Zhijian LIU, Zhuqing NEEL, Andrew JOHNSON, Heather Claire WANG, Lu SALEHI MARZUARANI, Nastaran JI CHEN, Yining |
| description | The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (2S,3R,4S,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-fluoro-4-hydroxy-2-(mercaptomethyl)tetrahydrofuran-3-yl dihydrogen phosphate, also known as 3´-fluoro-thio-guanosine monophosphate or 3´-F-thio-GMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation. (I)
La présente invention concerne des procédés efficaces utiles dans la préparation de nucléosides fluorés, tels que du (2S,3R,4S,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-fluoro-4-hydroxy-2-(mercaptométhyl) tétrahydrofuran-3-yl dihydrogène phosphate, également appelé 3'-fluoro-thio-guanosine monophosphate ou 3´-F-thio-GMP. De tels nucléosides fluorés peuvent être utiles en tant que composé biologiquement actif et ou en tant qu'intermédiaire pour la synthèse de composés biologiquement actifs plus complexes. La présente invention concerne également des intermédiaires utiles dans les procédés de synthèse décrits et leurs procédés de préparation. (I) |
| format | Patent |
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La présente invention concerne des procédés efficaces utiles dans la préparation de nucléosides fluorés, tels que du (2S,3R,4S,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-fluoro-4-hydroxy-2-(mercaptométhyl) tétrahydrofuran-3-yl dihydrogène phosphate, également appelé 3'-fluoro-thio-guanosine monophosphate ou 3´-F-thio-GMP. De tels nucléosides fluorés peuvent être utiles en tant que composé biologiquement actif et ou en tant qu'intermédiaire pour la synthèse de composés biologiquement actifs plus complexes. La présente invention concerne également des intermédiaires utiles dans les procédés de synthèse décrits et leurs procédés de préparation. (I)</description><language>eng ; fre</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211125&DB=EPODOC&CC=WO&NR=2021236859A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25569,76552</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211125&DB=EPODOC&CC=WO&NR=2021236859A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TURNBULL, Ben William Hulme</creatorcontrib><creatorcontrib>XU, Feng</creatorcontrib><creatorcontrib>ARMIGER, Travis</creatorcontrib><creatorcontrib>BENKOVICS, Tamas</creatorcontrib><creatorcontrib>MOORE, Jeffrey</creatorcontrib><creatorcontrib>SONG, Zhiguo Jake</creatorcontrib><creatorcontrib>PENG, Feng</creatorcontrib><creatorcontrib>KLAPARS, Artis</creatorcontrib><creatorcontrib>SHERRY, Benjamin</creatorcontrib><creatorcontrib>BELYK, Kevin</creatorcontrib><creatorcontrib>RUMMELT, Stephan</creatorcontrib><creatorcontrib>CHUNG, Cheol</creatorcontrib><creatorcontrib>LIU, Zhijian</creatorcontrib><creatorcontrib>LIU, Zhuqing</creatorcontrib><creatorcontrib>NEEL, Andrew</creatorcontrib><creatorcontrib>JOHNSON, Heather Claire</creatorcontrib><creatorcontrib>WANG, Lu</creatorcontrib><creatorcontrib>SALEHI MARZUARANI, Nastaran</creatorcontrib><creatorcontrib>JI CHEN, Yining</creatorcontrib><title>SYNTHESIS OF FLUORINATED NUCLEOTIDES</title><description>The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (2S,3R,4S,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-fluoro-4-hydroxy-2-(mercaptomethyl)tetrahydrofuran-3-yl dihydrogen phosphate, also known as 3´-fluoro-thio-guanosine monophosphate or 3´-F-thio-GMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation. (I)
La présente invention concerne des procédés efficaces utiles dans la préparation de nucléosides fluorés, tels que du (2S,3R,4S,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-fluoro-4-hydroxy-2-(mercaptométhyl) tétrahydrofuran-3-yl dihydrogène phosphate, également appelé 3'-fluoro-thio-guanosine monophosphate ou 3´-F-thio-GMP. De tels nucléosides fluorés peuvent être utiles en tant que composé biologiquement actif et ou en tant qu'intermédiaire pour la synthèse de composés biologiquement actifs plus complexes. La présente invention concerne également des intermédiaires utiles dans les procédés de synthèse décrits et leurs procédés de préparation. (I)</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFAJjvQL8XAN9gxW8HdTcPMJ9Q_y9HMMcXVR8At19nH1D_F0cQ3mYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXx4f5GBkaGRsZmFqaWjobGxKkCACuAJEI</recordid><startdate>20211125</startdate><enddate>20211125</enddate><creator>TURNBULL, Ben William Hulme</creator><creator>XU, Feng</creator><creator>ARMIGER, Travis</creator><creator>BENKOVICS, Tamas</creator><creator>MOORE, Jeffrey</creator><creator>SONG, Zhiguo Jake</creator><creator>PENG, Feng</creator><creator>KLAPARS, Artis</creator><creator>SHERRY, Benjamin</creator><creator>BELYK, Kevin</creator><creator>RUMMELT, Stephan</creator><creator>CHUNG, Cheol</creator><creator>LIU, Zhijian</creator><creator>LIU, Zhuqing</creator><creator>NEEL, Andrew</creator><creator>JOHNSON, Heather Claire</creator><creator>WANG, Lu</creator><creator>SALEHI MARZUARANI, Nastaran</creator><creator>JI CHEN, Yining</creator><scope>EVB</scope></search><sort><creationdate>20211125</creationdate><title>SYNTHESIS OF FLUORINATED NUCLEOTIDES</title><author>TURNBULL, Ben William Hulme ; XU, Feng ; ARMIGER, Travis ; BENKOVICS, Tamas ; MOORE, Jeffrey ; SONG, Zhiguo Jake ; PENG, Feng ; KLAPARS, Artis ; SHERRY, Benjamin ; BELYK, Kevin ; RUMMELT, Stephan ; CHUNG, Cheol ; LIU, Zhijian ; LIU, Zhuqing ; NEEL, Andrew ; JOHNSON, Heather Claire ; WANG, Lu ; SALEHI MARZUARANI, Nastaran ; JI CHEN, Yining</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2021236859A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2021</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>TURNBULL, Ben William Hulme</creatorcontrib><creatorcontrib>XU, Feng</creatorcontrib><creatorcontrib>ARMIGER, Travis</creatorcontrib><creatorcontrib>BENKOVICS, Tamas</creatorcontrib><creatorcontrib>MOORE, Jeffrey</creatorcontrib><creatorcontrib>SONG, Zhiguo Jake</creatorcontrib><creatorcontrib>PENG, Feng</creatorcontrib><creatorcontrib>KLAPARS, Artis</creatorcontrib><creatorcontrib>SHERRY, Benjamin</creatorcontrib><creatorcontrib>BELYK, Kevin</creatorcontrib><creatorcontrib>RUMMELT, Stephan</creatorcontrib><creatorcontrib>CHUNG, Cheol</creatorcontrib><creatorcontrib>LIU, Zhijian</creatorcontrib><creatorcontrib>LIU, Zhuqing</creatorcontrib><creatorcontrib>NEEL, Andrew</creatorcontrib><creatorcontrib>JOHNSON, Heather Claire</creatorcontrib><creatorcontrib>WANG, Lu</creatorcontrib><creatorcontrib>SALEHI MARZUARANI, Nastaran</creatorcontrib><creatorcontrib>JI CHEN, Yining</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>TURNBULL, Ben William Hulme</au><au>XU, Feng</au><au>ARMIGER, Travis</au><au>BENKOVICS, Tamas</au><au>MOORE, Jeffrey</au><au>SONG, Zhiguo Jake</au><au>PENG, Feng</au><au>KLAPARS, Artis</au><au>SHERRY, Benjamin</au><au>BELYK, Kevin</au><au>RUMMELT, Stephan</au><au>CHUNG, Cheol</au><au>LIU, Zhijian</au><au>LIU, Zhuqing</au><au>NEEL, Andrew</au><au>JOHNSON, Heather Claire</au><au>WANG, Lu</au><au>SALEHI MARZUARANI, Nastaran</au><au>JI CHEN, Yining</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SYNTHESIS OF FLUORINATED NUCLEOTIDES</title><date>2021-11-25</date><risdate>2021</risdate><abstract>The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (2S,3R,4S,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-fluoro-4-hydroxy-2-(mercaptomethyl)tetrahydrofuran-3-yl dihydrogen phosphate, also known as 3´-fluoro-thio-guanosine monophosphate or 3´-F-thio-GMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation. (I)
La présente invention concerne des procédés efficaces utiles dans la préparation de nucléosides fluorés, tels que du (2S,3R,4S,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-fluoro-4-hydroxy-2-(mercaptométhyl) tétrahydrofuran-3-yl dihydrogène phosphate, également appelé 3'-fluoro-thio-guanosine monophosphate ou 3´-F-thio-GMP. De tels nucléosides fluorés peuvent être utiles en tant que composé biologiquement actif et ou en tant qu'intermédiaire pour la synthèse de composés biologiquement actifs plus complexes. La présente invention concerne également des intermédiaires utiles dans les procédés de synthèse décrits et leurs procédés de préparation. (I)</abstract><oa>free_for_read</oa></addata></record> |
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| title | SYNTHESIS OF FLUORINATED NUCLEOTIDES |
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