BENZIMIDAZOLE THIOPHENE DERIVATIVE COMPOUNDS INDUCING SELECTIVE DEGRADATION OF PLK1
The present invention provides novel compounds that induce selective polo-like kinase 1 (PLK1) degradation. Specifically, the present invention provides a bifunctional compound in which a PLK1 binding moiety and an E3 ubiquitin ligase-binding moiety are linked by a chemical linker. The present inven...
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| creator | NAM, Boas CHOI, Si Woo RYU, Hye Guk RYU, Ji Hoon RYU, Soo Hee MIN, Im Suk LEE, Hwa Jin KIM, Seong Hoon KANG, Keum Young SON, San Ha |
| description | The present invention provides novel compounds that induce selective polo-like kinase 1 (PLK1) degradation. Specifically, the present invention provides a bifunctional compound in which a PLK1 binding moiety and an E3 ubiquitin ligase-binding moiety are linked by a chemical linker. The present invention provides the compound, a method for preparing the same, and the use thereof. The compounds may be effectively utilized for preventing or treating PLK1 related diseases.
La présente invention concerne de nouveaux composés qui induisent la dégradation sélective de la kinase 1 de type polo (PLK1). Spécifiquement, la présente invention concerne un composé bifonctionnel dans lequel une fraction de liaison de PLK1 et une fraction de liaison de ligase d'ubiquitine E3 sont liées par un lieur chimique. La présente invention concerne le composé, son procédé de préparation et son utilisation. Les composés peuvent être utilisés efficacement pour prévenir ou traiter des maladies associées à PLK1. |
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La présente invention concerne de nouveaux composés qui induisent la dégradation sélective de la kinase 1 de type polo (PLK1). Spécifiquement, la présente invention concerne un composé bifonctionnel dans lequel une fraction de liaison de PLK1 et une fraction de liaison de ligase d'ubiquitine E3 sont liées par un lieur chimique. La présente invention concerne le composé, son procédé de préparation et son utilisation. Les composés peuvent être utilisés efficacement pour prévenir ou traiter des maladies associées à PLK1.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210930&DB=EPODOC&CC=WO&NR=2021194321A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210930&DB=EPODOC&CC=WO&NR=2021194321A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>NAM, Boas</creatorcontrib><creatorcontrib>CHOI, Si Woo</creatorcontrib><creatorcontrib>RYU, Hye Guk</creatorcontrib><creatorcontrib>RYU, Ji Hoon</creatorcontrib><creatorcontrib>RYU, Soo Hee</creatorcontrib><creatorcontrib>MIN, Im Suk</creatorcontrib><creatorcontrib>LEE, Hwa Jin</creatorcontrib><creatorcontrib>KIM, Seong Hoon</creatorcontrib><creatorcontrib>KANG, Keum Young</creatorcontrib><creatorcontrib>SON, San Ha</creatorcontrib><title>BENZIMIDAZOLE THIOPHENE DERIVATIVE COMPOUNDS INDUCING SELECTIVE DEGRADATION OF PLK1</title><description>The present invention provides novel compounds that induce selective polo-like kinase 1 (PLK1) degradation. Specifically, the present invention provides a bifunctional compound in which a PLK1 binding moiety and an E3 ubiquitin ligase-binding moiety are linked by a chemical linker. The present invention provides the compound, a method for preparing the same, and the use thereof. The compounds may be effectively utilized for preventing or treating PLK1 related diseases.
La présente invention concerne de nouveaux composés qui induisent la dégradation sélective de la kinase 1 de type polo (PLK1). Spécifiquement, la présente invention concerne un composé bifonctionnel dans lequel une fraction de liaison de PLK1 et une fraction de liaison de ligase d'ubiquitine E3 sont liées par un lieur chimique. La présente invention concerne le composé, son procédé de préparation et son utilisation. Les composés peuvent être utilisés efficacement pour prévenir ou traiter des maladies associées à PLK1.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrEKwjAQgOEsDqK-w4GzYFIXx5hcm8M2V5q0QpdSJE6ihfr-KOIDOP3D_y1FOKHvqSKrey4RoiOuHXoEiw11OlKHYLiqufU2AHnbGvIFBCzRfKfFotH2A9kD51CXZ7kWi9t4n9Pm15XY5hiN26XpOaR5Gq_pkV7DhdVeSXk8ZEpqmf2n3u73MPw</recordid><startdate>20210930</startdate><enddate>20210930</enddate><creator>NAM, Boas</creator><creator>CHOI, Si Woo</creator><creator>RYU, Hye Guk</creator><creator>RYU, Ji Hoon</creator><creator>RYU, Soo Hee</creator><creator>MIN, Im Suk</creator><creator>LEE, Hwa Jin</creator><creator>KIM, Seong Hoon</creator><creator>KANG, Keum Young</creator><creator>SON, San Ha</creator><scope>EVB</scope></search><sort><creationdate>20210930</creationdate><title>BENZIMIDAZOLE THIOPHENE DERIVATIVE COMPOUNDS INDUCING SELECTIVE DEGRADATION OF PLK1</title><author>NAM, Boas ; CHOI, Si Woo ; RYU, Hye Guk ; RYU, Ji Hoon ; RYU, Soo Hee ; MIN, Im Suk ; LEE, Hwa Jin ; KIM, Seong Hoon ; KANG, Keum Young ; SON, San Ha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2021194321A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2021</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>NAM, Boas</creatorcontrib><creatorcontrib>CHOI, Si Woo</creatorcontrib><creatorcontrib>RYU, Hye Guk</creatorcontrib><creatorcontrib>RYU, Ji Hoon</creatorcontrib><creatorcontrib>RYU, Soo Hee</creatorcontrib><creatorcontrib>MIN, Im Suk</creatorcontrib><creatorcontrib>LEE, Hwa Jin</creatorcontrib><creatorcontrib>KIM, Seong Hoon</creatorcontrib><creatorcontrib>KANG, Keum Young</creatorcontrib><creatorcontrib>SON, San Ha</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>NAM, Boas</au><au>CHOI, Si Woo</au><au>RYU, Hye Guk</au><au>RYU, Ji Hoon</au><au>RYU, Soo Hee</au><au>MIN, Im Suk</au><au>LEE, Hwa Jin</au><au>KIM, Seong Hoon</au><au>KANG, Keum Young</au><au>SON, San Ha</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>BENZIMIDAZOLE THIOPHENE DERIVATIVE COMPOUNDS INDUCING SELECTIVE DEGRADATION OF PLK1</title><date>2021-09-30</date><risdate>2021</risdate><abstract>The present invention provides novel compounds that induce selective polo-like kinase 1 (PLK1) degradation. Specifically, the present invention provides a bifunctional compound in which a PLK1 binding moiety and an E3 ubiquitin ligase-binding moiety are linked by a chemical linker. The present invention provides the compound, a method for preparing the same, and the use thereof. The compounds may be effectively utilized for preventing or treating PLK1 related diseases.
La présente invention concerne de nouveaux composés qui induisent la dégradation sélective de la kinase 1 de type polo (PLK1). Spécifiquement, la présente invention concerne un composé bifonctionnel dans lequel une fraction de liaison de PLK1 et une fraction de liaison de ligase d'ubiquitine E3 sont liées par un lieur chimique. La présente invention concerne le composé, son procédé de préparation et son utilisation. Les composés peuvent être utilisés efficacement pour prévenir ou traiter des maladies associées à PLK1.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | BENZIMIDAZOLE THIOPHENE DERIVATIVE COMPOUNDS INDUCING SELECTIVE DEGRADATION OF PLK1 |
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