SUBSTITUTED PYRIDAZINE COMPOUND
The present invention addresses the problem of providing a pharmaceutical composition, in particular a compound suitable for prevention and/or treatment of an inflammatory disease and/or a neurodegenerative disease. The inventors of the present invention conducted extensive studies to find a compoun...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre ; jpn |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | NEGORO, Kenji SABA, Kengo IIDA, Maiko KOIZUMI, Yuka YAMAKI, Susumu INAGAKI, Yusuke KOIKE, Takanori MAEDA, Junko KAMIKUBO, Takashi NIGAWARA, Takahiro KURIWAKI, Ikumi SHISHIKURA, Junichi |
| description | The present invention addresses the problem of providing a pharmaceutical composition, in particular a compound suitable for prevention and/or treatment of an inflammatory disease and/or a neurodegenerative disease. The inventors of the present invention conducted extensive studies to find a compound that has suppressive action on NLRP3 inflammasome activation, and found that a substituted pyridazine compound has suppressive action on NLRP3 inflammasome activation, leading to completion of the present invention. The substituted pyridazine compound according to the present invention is expected to serve as a drug for prevention and/or treatment of an inflammatory disease and/or a neurodegenerative disease.
La présente invention aborde le problème de la fourniture d'une composition pharmaceutique, en particulier d'un composé approprié pour la prévention et/ou le traitement d'une maladie inflammatoire et/ou d'une maladie neurodégénérative. Les inventeurs de la présente invention ont effectué des études approfondies pour trouver un composé qui a une action suppressive sur l'activation de l'inflammation de NLRP3, et il a été découvert qu'un composé de pyridazine substitué a une action suppressive sur l'activation de l'inflammation de NLRP3, conduisant ainsi à la présente invention. Le composé de pyridazine substitué selon la présente invention est prévu pour servir de médicament pour la prévention et/ou le traitement d'une maladie inflammatoire et/ou d'une maladie neurodégénérative.
本発明の課題は、医薬組成物、特に炎症性疾患及び／又は神経変性疾患の予防及び ／又は治療に適した化合物を提供することである。 本発明者らは、NLRP3インフラマソーム活性化抑制作用を有する化合物の探索を鋭意 検討し、置換ピリダジン化合物がNLRP3インフラマソーム活性化抑制作用を有すること を知見して本発明を完成した。本発明の置換ピリダジン化合物は、炎症性疾患及び／ 又は神経変性疾患の予防及び／又は治療薬として期待される。 |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO2021193897A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO2021193897A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO2021193897A13</originalsourceid><addsrcrecordid>eNrjZJAPDnUKDvEMCQ1xdVEIiAzydHGM8vRzVXD29w3wD_Vz4WFgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8eH-RgZGhoaWxhaW5o6GxsSpAgCNCSMO</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>SUBSTITUTED PYRIDAZINE COMPOUND</title><source>esp@cenet</source><creator>NEGORO, Kenji ; SABA, Kengo ; IIDA, Maiko ; KOIZUMI, Yuka ; YAMAKI, Susumu ; INAGAKI, Yusuke ; KOIKE, Takanori ; MAEDA, Junko ; KAMIKUBO, Takashi ; NIGAWARA, Takahiro ; KURIWAKI, Ikumi ; SHISHIKURA, Junichi</creator><creatorcontrib>NEGORO, Kenji ; SABA, Kengo ; IIDA, Maiko ; KOIZUMI, Yuka ; YAMAKI, Susumu ; INAGAKI, Yusuke ; KOIKE, Takanori ; MAEDA, Junko ; KAMIKUBO, Takashi ; NIGAWARA, Takahiro ; KURIWAKI, Ikumi ; SHISHIKURA, Junichi</creatorcontrib><description>The present invention addresses the problem of providing a pharmaceutical composition, in particular a compound suitable for prevention and/or treatment of an inflammatory disease and/or a neurodegenerative disease. The inventors of the present invention conducted extensive studies to find a compound that has suppressive action on NLRP3 inflammasome activation, and found that a substituted pyridazine compound has suppressive action on NLRP3 inflammasome activation, leading to completion of the present invention. The substituted pyridazine compound according to the present invention is expected to serve as a drug for prevention and/or treatment of an inflammatory disease and/or a neurodegenerative disease.
La présente invention aborde le problème de la fourniture d'une composition pharmaceutique, en particulier d'un composé approprié pour la prévention et/ou le traitement d'une maladie inflammatoire et/ou d'une maladie neurodégénérative. Les inventeurs de la présente invention ont effectué des études approfondies pour trouver un composé qui a une action suppressive sur l'activation de l'inflammation de NLRP3, et il a été découvert qu'un composé de pyridazine substitué a une action suppressive sur l'activation de l'inflammation de NLRP3, conduisant ainsi à la présente invention. Le composé de pyridazine substitué selon la présente invention est prévu pour servir de médicament pour la prévention et/ou le traitement d'une maladie inflammatoire et/ou d'une maladie neurodégénérative.
本発明の課題は、医薬組成物、特に炎症性疾患及び／又は神経変性疾患の予防及び ／又は治療に適した化合物を提供することである。 本発明者らは、NLRP3インフラマソーム活性化抑制作用を有する化合物の探索を鋭意 検討し、置換ピリダジン化合物がNLRP3インフラマソーム活性化抑制作用を有すること を知見して本発明を完成した。本発明の置換ピリダジン化合物は、炎症性疾患及び／ 又は神経変性疾患の予防及び／又は治療薬として期待される。</description><language>eng ; fre ; jpn</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210930&DB=EPODOC&CC=WO&NR=2021193897A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25553,76306</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210930&DB=EPODOC&CC=WO&NR=2021193897A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>NEGORO, Kenji</creatorcontrib><creatorcontrib>SABA, Kengo</creatorcontrib><creatorcontrib>IIDA, Maiko</creatorcontrib><creatorcontrib>KOIZUMI, Yuka</creatorcontrib><creatorcontrib>YAMAKI, Susumu</creatorcontrib><creatorcontrib>INAGAKI, Yusuke</creatorcontrib><creatorcontrib>KOIKE, Takanori</creatorcontrib><creatorcontrib>MAEDA, Junko</creatorcontrib><creatorcontrib>KAMIKUBO, Takashi</creatorcontrib><creatorcontrib>NIGAWARA, Takahiro</creatorcontrib><creatorcontrib>KURIWAKI, Ikumi</creatorcontrib><creatorcontrib>SHISHIKURA, Junichi</creatorcontrib><title>SUBSTITUTED PYRIDAZINE COMPOUND</title><description>The present invention addresses the problem of providing a pharmaceutical composition, in particular a compound suitable for prevention and/or treatment of an inflammatory disease and/or a neurodegenerative disease. The inventors of the present invention conducted extensive studies to find a compound that has suppressive action on NLRP3 inflammasome activation, and found that a substituted pyridazine compound has suppressive action on NLRP3 inflammasome activation, leading to completion of the present invention. The substituted pyridazine compound according to the present invention is expected to serve as a drug for prevention and/or treatment of an inflammatory disease and/or a neurodegenerative disease.
La présente invention aborde le problème de la fourniture d'une composition pharmaceutique, en particulier d'un composé approprié pour la prévention et/ou le traitement d'une maladie inflammatoire et/ou d'une maladie neurodégénérative. Les inventeurs de la présente invention ont effectué des études approfondies pour trouver un composé qui a une action suppressive sur l'activation de l'inflammation de NLRP3, et il a été découvert qu'un composé de pyridazine substitué a une action suppressive sur l'activation de l'inflammation de NLRP3, conduisant ainsi à la présente invention. Le composé de pyridazine substitué selon la présente invention est prévu pour servir de médicament pour la prévention et/ou le traitement d'une maladie inflammatoire et/ou d'une maladie neurodégénérative.
本発明の課題は、医薬組成物、特に炎症性疾患及び／又は神経変性疾患の予防及び ／又は治療に適した化合物を提供することである。 本発明者らは、NLRP3インフラマソーム活性化抑制作用を有する化合物の探索を鋭意 検討し、置換ピリダジン化合物がNLRP3インフラマソーム活性化抑制作用を有すること を知見して本発明を完成した。本発明の置換ピリダジン化合物は、炎症性疾患及び／ 又は神経変性疾患の予防及び／又は治療薬として期待される。</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJAPDnUKDvEMCQ1xdVEIiAzydHGM8vRzVXD29w3wD_Vz4WFgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8eH-RgZGhoaWxhaW5o6GxsSpAgCNCSMO</recordid><startdate>20210930</startdate><enddate>20210930</enddate><creator>NEGORO, Kenji</creator><creator>SABA, Kengo</creator><creator>IIDA, Maiko</creator><creator>KOIZUMI, Yuka</creator><creator>YAMAKI, Susumu</creator><creator>INAGAKI, Yusuke</creator><creator>KOIKE, Takanori</creator><creator>MAEDA, Junko</creator><creator>KAMIKUBO, Takashi</creator><creator>NIGAWARA, Takahiro</creator><creator>KURIWAKI, Ikumi</creator><creator>SHISHIKURA, Junichi</creator><scope>EVB</scope></search><sort><creationdate>20210930</creationdate><title>SUBSTITUTED PYRIDAZINE COMPOUND</title><author>NEGORO, Kenji ; SABA, Kengo ; IIDA, Maiko ; KOIZUMI, Yuka ; YAMAKI, Susumu ; INAGAKI, Yusuke ; KOIKE, Takanori ; MAEDA, Junko ; KAMIKUBO, Takashi ; NIGAWARA, Takahiro ; KURIWAKI, Ikumi ; SHISHIKURA, Junichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2021193897A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; jpn</language><creationdate>2021</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>NEGORO, Kenji</creatorcontrib><creatorcontrib>SABA, Kengo</creatorcontrib><creatorcontrib>IIDA, Maiko</creatorcontrib><creatorcontrib>KOIZUMI, Yuka</creatorcontrib><creatorcontrib>YAMAKI, Susumu</creatorcontrib><creatorcontrib>INAGAKI, Yusuke</creatorcontrib><creatorcontrib>KOIKE, Takanori</creatorcontrib><creatorcontrib>MAEDA, Junko</creatorcontrib><creatorcontrib>KAMIKUBO, Takashi</creatorcontrib><creatorcontrib>NIGAWARA, Takahiro</creatorcontrib><creatorcontrib>KURIWAKI, Ikumi</creatorcontrib><creatorcontrib>SHISHIKURA, Junichi</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>NEGORO, Kenji</au><au>SABA, Kengo</au><au>IIDA, Maiko</au><au>KOIZUMI, Yuka</au><au>YAMAKI, Susumu</au><au>INAGAKI, Yusuke</au><au>KOIKE, Takanori</au><au>MAEDA, Junko</au><au>KAMIKUBO, Takashi</au><au>NIGAWARA, Takahiro</au><au>KURIWAKI, Ikumi</au><au>SHISHIKURA, Junichi</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SUBSTITUTED PYRIDAZINE COMPOUND</title><date>2021-09-30</date><risdate>2021</risdate><abstract>The present invention addresses the problem of providing a pharmaceutical composition, in particular a compound suitable for prevention and/or treatment of an inflammatory disease and/or a neurodegenerative disease. The inventors of the present invention conducted extensive studies to find a compound that has suppressive action on NLRP3 inflammasome activation, and found that a substituted pyridazine compound has suppressive action on NLRP3 inflammasome activation, leading to completion of the present invention. The substituted pyridazine compound according to the present invention is expected to serve as a drug for prevention and/or treatment of an inflammatory disease and/or a neurodegenerative disease.
La présente invention aborde le problème de la fourniture d'une composition pharmaceutique, en particulier d'un composé approprié pour la prévention et/ou le traitement d'une maladie inflammatoire et/ou d'une maladie neurodégénérative. Les inventeurs de la présente invention ont effectué des études approfondies pour trouver un composé qui a une action suppressive sur l'activation de l'inflammation de NLRP3, et il a été découvert qu'un composé de pyridazine substitué a une action suppressive sur l'activation de l'inflammation de NLRP3, conduisant ainsi à la présente invention. Le composé de pyridazine substitué selon la présente invention est prévu pour servir de médicament pour la prévention et/ou le traitement d'une maladie inflammatoire et/ou d'une maladie neurodégénérative.
本発明の課題は、医薬組成物、特に炎症性疾患及び／又は神経変性疾患の予防及び ／又は治療に適した化合物を提供することである。 本発明者らは、NLRP3インフラマソーム活性化抑制作用を有する化合物の探索を鋭意 検討し、置換ピリダジン化合物がNLRP3インフラマソーム活性化抑制作用を有すること を知見して本発明を完成した。本発明の置換ピリダジン化合物は、炎症性疾患及び／ 又は神経変性疾患の予防及び／又は治療薬として期待される。</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre ; jpn |
| recordid | cdi_epo_espacenet_WO2021193897A1 |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | SUBSTITUTED PYRIDAZINE COMPOUND |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T09%3A41%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=NEGORO,%20Kenji&rft.date=2021-09-30&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EWO2021193897A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |