TETRALIN AND TETRAHYDROQUINOLINE COMPOUNDS AS INHIBITORS OF HIF-2ALPHA
Compounds that inhibit HIF-2a, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases disorders, and conditions, including cancer- and...
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| creator | DREW, Samuel Lawrie EPPLIN, Matthew MOON, Hyunyoung LINDSEY, Erick Allen LAWSON, Kenneth Victor POWERS, Jay Patrick BEATTY, Joel Worley GAL, Balint JACOB, Steven Donald MAILYAN, Artur Karenovich FOURNIER, Jeremy Thomas Andre MANDAL, Debashis LELETI, Manmohan Reddy WANG, Zhang KALISIAK, Jaroslaw MATA, Guillaume ROSEN, Brandon Reid JEFFREY, Jenna Leigh HAELSIG, Karl T HARDMAN, Clayton TRAN, Anh Thu YU, Kai SU, Yongli GUNEY, Tezcan YAN, Xuelei |
| description | Compounds that inhibit HIF-2a, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2a.
L'invention concerne des composés qui inhibent HIF-2α, et des compositions contenant le ou les composés et des procédés de synthèse des composés. L'invention concerne également l'utilisation de tels composés et compositions pour le traitement d'un réseau divers de maladies, de troubles et d'états, comprenant des troubles liés au cancer et à l'immunité qui sont médiés, au moins en partie, par HIF-2α. |
| format | Patent |
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L'invention concerne des composés qui inhibent HIF-2α, et des compositions contenant le ou les composés et des procédés de synthèse des composés. L'invention concerne également l'utilisation de tels composés et compositions pour le traitement d'un réseau divers de maladies, de troubles et d'états, comprenant des troubles liés au cancer et à l'immunité qui sont médiés, au moins en partie, par HIF-2α.</description><language>eng ; fre</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210923&DB=EPODOC&CC=WO&NR=2021188769A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25568,76551</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210923&DB=EPODOC&CC=WO&NR=2021188769A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DREW, Samuel Lawrie</creatorcontrib><creatorcontrib>EPPLIN, Matthew</creatorcontrib><creatorcontrib>MOON, Hyunyoung</creatorcontrib><creatorcontrib>LINDSEY, Erick Allen</creatorcontrib><creatorcontrib>LAWSON, Kenneth Victor</creatorcontrib><creatorcontrib>POWERS, Jay Patrick</creatorcontrib><creatorcontrib>BEATTY, Joel Worley</creatorcontrib><creatorcontrib>GAL, Balint</creatorcontrib><creatorcontrib>JACOB, Steven Donald</creatorcontrib><creatorcontrib>MAILYAN, Artur Karenovich</creatorcontrib><creatorcontrib>FOURNIER, Jeremy Thomas Andre</creatorcontrib><creatorcontrib>MANDAL, Debashis</creatorcontrib><creatorcontrib>LELETI, Manmohan Reddy</creatorcontrib><creatorcontrib>WANG, Zhang</creatorcontrib><creatorcontrib>KALISIAK, Jaroslaw</creatorcontrib><creatorcontrib>MATA, Guillaume</creatorcontrib><creatorcontrib>ROSEN, Brandon Reid</creatorcontrib><creatorcontrib>JEFFREY, Jenna Leigh</creatorcontrib><creatorcontrib>HAELSIG, Karl T</creatorcontrib><creatorcontrib>HARDMAN, Clayton</creatorcontrib><creatorcontrib>TRAN, Anh Thu</creatorcontrib><creatorcontrib>YU, Kai</creatorcontrib><creatorcontrib>SU, Yongli</creatorcontrib><creatorcontrib>GUNEY, Tezcan</creatorcontrib><creatorcontrib>YAN, Xuelei</creatorcontrib><title>TETRALIN AND TETRAHYDROQUINOLINE COMPOUNDS AS INHIBITORS OF HIF-2ALPHA</title><description>Compounds that inhibit HIF-2a, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2a.
L'invention concerne des composés qui inhibent HIF-2α, et des compositions contenant le ou les composés et des procédés de synthèse des composés. L'invention concerne également l'utilisation de tels composés et compositions pour le traitement d'un réseau divers de maladies, de troubles et d'états, comprenant des troubles liés au cancer et à l'immunité qui sont médiés, au moins en partie, par HIF-2α.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHALcQ0JcvTx9FNw9HNRAHM8Il2C_ANDPf38gcKuCs7-vgH-oX4uwQqOwQqefh6eTp4h_kHBCv5uCh6ebrpGjj4BHo48DKxpiTnFqbxQmptB2c01xNlDN7UgPz61uCAxOTUvtSQ-3N_IwMjQ0MLC3MzS0dCYOFUAhDctfQ</recordid><startdate>20210923</startdate><enddate>20210923</enddate><creator>DREW, Samuel Lawrie</creator><creator>EPPLIN, Matthew</creator><creator>MOON, Hyunyoung</creator><creator>LINDSEY, Erick Allen</creator><creator>LAWSON, Kenneth Victor</creator><creator>POWERS, Jay Patrick</creator><creator>BEATTY, Joel Worley</creator><creator>GAL, Balint</creator><creator>JACOB, Steven Donald</creator><creator>MAILYAN, Artur Karenovich</creator><creator>FOURNIER, Jeremy Thomas Andre</creator><creator>MANDAL, Debashis</creator><creator>LELETI, Manmohan Reddy</creator><creator>WANG, Zhang</creator><creator>KALISIAK, Jaroslaw</creator><creator>MATA, Guillaume</creator><creator>ROSEN, Brandon Reid</creator><creator>JEFFREY, Jenna Leigh</creator><creator>HAELSIG, Karl T</creator><creator>HARDMAN, Clayton</creator><creator>TRAN, Anh Thu</creator><creator>YU, Kai</creator><creator>SU, Yongli</creator><creator>GUNEY, Tezcan</creator><creator>YAN, Xuelei</creator><scope>EVB</scope></search><sort><creationdate>20210923</creationdate><title>TETRALIN AND TETRAHYDROQUINOLINE COMPOUNDS AS INHIBITORS OF HIF-2ALPHA</title><author>DREW, Samuel Lawrie ; EPPLIN, Matthew ; MOON, Hyunyoung ; LINDSEY, Erick Allen ; LAWSON, Kenneth Victor ; POWERS, Jay Patrick ; BEATTY, Joel Worley ; GAL, Balint ; JACOB, Steven Donald ; MAILYAN, Artur Karenovich ; FOURNIER, Jeremy Thomas Andre ; MANDAL, Debashis ; LELETI, Manmohan Reddy ; WANG, Zhang ; KALISIAK, Jaroslaw ; MATA, Guillaume ; ROSEN, Brandon Reid ; JEFFREY, Jenna Leigh ; HAELSIG, Karl T ; HARDMAN, Clayton ; TRAN, Anh Thu ; YU, Kai ; SU, Yongli ; GUNEY, Tezcan ; YAN, Xuelei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2021188769A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2021</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>DREW, Samuel Lawrie</creatorcontrib><creatorcontrib>EPPLIN, Matthew</creatorcontrib><creatorcontrib>MOON, Hyunyoung</creatorcontrib><creatorcontrib>LINDSEY, Erick Allen</creatorcontrib><creatorcontrib>LAWSON, Kenneth Victor</creatorcontrib><creatorcontrib>POWERS, Jay Patrick</creatorcontrib><creatorcontrib>BEATTY, Joel Worley</creatorcontrib><creatorcontrib>GAL, Balint</creatorcontrib><creatorcontrib>JACOB, Steven Donald</creatorcontrib><creatorcontrib>MAILYAN, Artur Karenovich</creatorcontrib><creatorcontrib>FOURNIER, Jeremy Thomas Andre</creatorcontrib><creatorcontrib>MANDAL, Debashis</creatorcontrib><creatorcontrib>LELETI, Manmohan Reddy</creatorcontrib><creatorcontrib>WANG, Zhang</creatorcontrib><creatorcontrib>KALISIAK, Jaroslaw</creatorcontrib><creatorcontrib>MATA, Guillaume</creatorcontrib><creatorcontrib>ROSEN, Brandon Reid</creatorcontrib><creatorcontrib>JEFFREY, Jenna Leigh</creatorcontrib><creatorcontrib>HAELSIG, Karl T</creatorcontrib><creatorcontrib>HARDMAN, Clayton</creatorcontrib><creatorcontrib>TRAN, Anh Thu</creatorcontrib><creatorcontrib>YU, Kai</creatorcontrib><creatorcontrib>SU, Yongli</creatorcontrib><creatorcontrib>GUNEY, Tezcan</creatorcontrib><creatorcontrib>YAN, Xuelei</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DREW, Samuel Lawrie</au><au>EPPLIN, Matthew</au><au>MOON, Hyunyoung</au><au>LINDSEY, Erick Allen</au><au>LAWSON, Kenneth Victor</au><au>POWERS, Jay Patrick</au><au>BEATTY, Joel Worley</au><au>GAL, Balint</au><au>JACOB, Steven Donald</au><au>MAILYAN, Artur Karenovich</au><au>FOURNIER, Jeremy Thomas Andre</au><au>MANDAL, Debashis</au><au>LELETI, Manmohan Reddy</au><au>WANG, Zhang</au><au>KALISIAK, Jaroslaw</au><au>MATA, Guillaume</au><au>ROSEN, Brandon Reid</au><au>JEFFREY, Jenna Leigh</au><au>HAELSIG, Karl T</au><au>HARDMAN, Clayton</au><au>TRAN, Anh Thu</au><au>YU, Kai</au><au>SU, Yongli</au><au>GUNEY, Tezcan</au><au>YAN, Xuelei</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>TETRALIN AND TETRAHYDROQUINOLINE COMPOUNDS AS INHIBITORS OF HIF-2ALPHA</title><date>2021-09-23</date><risdate>2021</risdate><abstract>Compounds that inhibit HIF-2a, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2a.
L'invention concerne des composés qui inhibent HIF-2α, et des compositions contenant le ou les composés et des procédés de synthèse des composés. L'invention concerne également l'utilisation de tels composés et compositions pour le traitement d'un réseau divers de maladies, de troubles et d'états, comprenant des troubles liés au cancer et à l'immunité qui sont médiés, au moins en partie, par HIF-2α.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | TETRALIN AND TETRAHYDROQUINOLINE COMPOUNDS AS INHIBITORS OF HIF-2ALPHA |
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