HETEROCYCLIC COMPOUNDS AS DELTA-5 DESATURASE INHIBITORS AND METHODS OF USE
The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase ("D5D"). The compounds have a general Formula (I) wherein the variables of Formula (I) are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of t...
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| creator | BOURBEAU, Matthew P MINATTI, Ana E VINCETTI, Paolo ALLEN, Jennifer R DAMYANOVA, Teodora P BELTRANI, Michela LINGARD, Iain |
| description | The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase ("D5D"). The compounds have a general Formula (I) wherein the variables of Formula (I) are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).
La présente invention concerne des composés utiles pour l'inhibition de delta-5 désaturase (« D5D »). Les composés ont la formule générale (I) dans laquelle les variables de la formule (I) sont définies dans la description. L'invention concerne également des compositions pharmaceutiques comprenant les composés, des utilisations des composés et des compositions pour le traitement, par exemple, d'un trouble métabolique ou cardiovasculaire. L'invention concerne en outre des intermédiaires destinés à être utilisés dans la synthèse de composés de formule (I). |
| format | Patent |
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La présente invention concerne des composés utiles pour l'inhibition de delta-5 désaturase (« D5D »). Les composés ont la formule générale (I) dans laquelle les variables de la formule (I) sont définies dans la description. L'invention concerne également des compositions pharmaceutiques comprenant les composés, des utilisations des composés et des compositions pour le traitement, par exemple, d'un trouble métabolique ou cardiovasculaire. L'invention concerne en outre des intermédiaires destinés à être utilisés dans la synthèse de composés de formule (I).</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210603&DB=EPODOC&CC=WO&NR=2021108408A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210603&DB=EPODOC&CC=WO&NR=2021108408A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BOURBEAU, Matthew P</creatorcontrib><creatorcontrib>MINATTI, Ana E</creatorcontrib><creatorcontrib>VINCETTI, Paolo</creatorcontrib><creatorcontrib>ALLEN, Jennifer R</creatorcontrib><creatorcontrib>DAMYANOVA, Teodora P</creatorcontrib><creatorcontrib>BELTRANI, Michela</creatorcontrib><creatorcontrib>LINGARD, Iain</creatorcontrib><title>HETEROCYCLIC COMPOUNDS AS DELTA-5 DESATURASE INHIBITORS AND METHODS OF USE</title><description>The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase ("D5D"). The compounds have a general Formula (I) wherein the variables of Formula (I) are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).
La présente invention concerne des composés utiles pour l'inhibition de delta-5 désaturase (« D5D »). Les composés ont la formule générale (I) dans laquelle les variables de la formule (I) sont définies dans la description. L'invention concerne également des compositions pharmaceutiques comprenant les composés, des utilisations des composés et des compositions pour le traitement, par exemple, d'un trouble métabolique ou cardiovasculaire. L'invention concerne en outre des intermédiaires destinés à être utilisés dans la synthèse de composés de formule (I).</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPDycA1xDfJ3jnT28XRWcPb3DfAP9XMJVnAMVnBx9Qlx1DUF0sGOIaFBjsGuCp5-Hp5OniH-QUAFfi4Kvq4hHv5Axf5uCqHBrjwMrGmJOcWpvFCam0HZzTXE2UM3tSA_PrW4IDE5NS-1JD7c38jAyNDQwMLEwMLR0Jg4VQAH5C4g</recordid><startdate>20210603</startdate><enddate>20210603</enddate><creator>BOURBEAU, Matthew P</creator><creator>MINATTI, Ana E</creator><creator>VINCETTI, Paolo</creator><creator>ALLEN, Jennifer R</creator><creator>DAMYANOVA, Teodora P</creator><creator>BELTRANI, Michela</creator><creator>LINGARD, Iain</creator><scope>EVB</scope></search><sort><creationdate>20210603</creationdate><title>HETEROCYCLIC COMPOUNDS AS DELTA-5 DESATURASE INHIBITORS AND METHODS OF USE</title><author>BOURBEAU, Matthew P ; MINATTI, Ana E ; VINCETTI, Paolo ; ALLEN, Jennifer R ; DAMYANOVA, Teodora P ; BELTRANI, Michela ; LINGARD, Iain</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2021108408A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2021</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>BOURBEAU, Matthew P</creatorcontrib><creatorcontrib>MINATTI, Ana E</creatorcontrib><creatorcontrib>VINCETTI, Paolo</creatorcontrib><creatorcontrib>ALLEN, Jennifer R</creatorcontrib><creatorcontrib>DAMYANOVA, Teodora P</creatorcontrib><creatorcontrib>BELTRANI, Michela</creatorcontrib><creatorcontrib>LINGARD, Iain</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BOURBEAU, Matthew P</au><au>MINATTI, Ana E</au><au>VINCETTI, Paolo</au><au>ALLEN, Jennifer R</au><au>DAMYANOVA, Teodora P</au><au>BELTRANI, Michela</au><au>LINGARD, Iain</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>HETEROCYCLIC COMPOUNDS AS DELTA-5 DESATURASE INHIBITORS AND METHODS OF USE</title><date>2021-06-03</date><risdate>2021</risdate><abstract>The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase ("D5D"). The compounds have a general Formula (I) wherein the variables of Formula (I) are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).
La présente invention concerne des composés utiles pour l'inhibition de delta-5 désaturase (« D5D »). Les composés ont la formule générale (I) dans laquelle les variables de la formule (I) sont définies dans la description. L'invention concerne également des compositions pharmaceutiques comprenant les composés, des utilisations des composés et des compositions pour le traitement, par exemple, d'un trouble métabolique ou cardiovasculaire. L'invention concerne en outre des intermédiaires destinés à être utilisés dans la synthèse de composés de formule (I).</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | HETEROCYCLIC COMPOUNDS AS DELTA-5 DESATURASE INHIBITORS AND METHODS OF USE |
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