SELECTIVE POLYPEPTIDE SYNTHESIS STALLING ASSAY AND COMPOUND
The invention relates to compounds, in particular pyrimidine-2,4-diamines, analogues and salts thereof and pharmaceutical compositions comprising pyrimidine-2,4-diamines analogues and salts thereof for use in the treatment and prevention of a disease, in particular a growth hormone receptor-dependen...
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| creator | PIET, Dennis Patrick VAN DER VELDEN, Lieke Marie STROUS, Gerardus Jacobus Antonius Maria MOL, Jan Adrianus KLUMPERMAN, Judith TIJHUIS, Johann Heinrich VIÉTOR, Hendrik Engelbertus DE KLERK-SPRENKELS, Nanda.Elisabeth VAN DER KRIFT, Felix MAAS, Petrus Emmanuel Marie MAURICE, Madelon Maria |
| description | The invention relates to compounds, in particular pyrimidine-2,4-diamines, analogues and salts thereof and pharmaceutical compositions comprising pyrimidine-2,4-diamines analogues and salts thereof for use in the treatment and prevention of a disease, in particular a growth hormone receptor-dependent condition. The invention also relates to methods of using these compounds and compositions to treat physiological disorders related to the amount or activity of growth hormone. In a particular embodiment, the invention relates to a compound according to formula 1 for use in the treatment or prevention of a disease in a subject.
L'invention concerne des composés, en particulier des pyrimidine-2,4-diamines, des analogues et des sels de ceux-ci et des compositions pharmaceutiques comprenant des analogues des pyrimidine-2,4-diamines et des sels de ceux-ci destinés à être utilisés dans le traitement et la prévention d'une maladie, en particulier d'une affection dépendant du récepteur de l'hormone de croissance. L'invention concerne également des méthodes d'utilisation de ces composés et compositions pour traiter des troubles physiologiques liés à la quantité ou à l'activité de l'hormone de croissance. Dans un mode de réalisation particulier, l'invention concerne un composé selon la formule 1 destiné à être utilisé dans le traitement ou la prévention d'une maladie chez un sujet. (Formule 1) |
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L'invention concerne des composés, en particulier des pyrimidine-2,4-diamines, des analogues et des sels de ceux-ci et des compositions pharmaceutiques comprenant des analogues des pyrimidine-2,4-diamines et des sels de ceux-ci destinés à être utilisés dans le traitement et la prévention d'une maladie, en particulier d'une affection dépendant du récepteur de l'hormone de croissance. L'invention concerne également des méthodes d'utilisation de ces composés et compositions pour traiter des troubles physiologiques liés à la quantité ou à l'activité de l'hormone de croissance. Dans un mode de réalisation particulier, l'invention concerne un composé selon la formule 1 destiné à être utilisé dans le traitement ou la prévention d'une maladie chez un sujet. (Formule 1)</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210429&DB=EPODOC&CC=WO&NR=2021078995A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76419</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210429&DB=EPODOC&CC=WO&NR=2021078995A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PIET, Dennis Patrick</creatorcontrib><creatorcontrib>VAN DER VELDEN, Lieke Marie</creatorcontrib><creatorcontrib>STROUS, Gerardus Jacobus Antonius Maria</creatorcontrib><creatorcontrib>MOL, Jan Adrianus</creatorcontrib><creatorcontrib>KLUMPERMAN, Judith</creatorcontrib><creatorcontrib>TIJHUIS, Johann Heinrich</creatorcontrib><creatorcontrib>VIÉTOR, Hendrik Engelbertus</creatorcontrib><creatorcontrib>DE KLERK-SPRENKELS, Nanda.Elisabeth</creatorcontrib><creatorcontrib>VAN DER KRIFT, Felix</creatorcontrib><creatorcontrib>MAAS, Petrus Emmanuel Marie</creatorcontrib><creatorcontrib>MAURICE, Madelon Maria</creatorcontrib><title>SELECTIVE POLYPEPTIDE SYNTHESIS STALLING ASSAY AND COMPOUND</title><description>The invention relates to compounds, in particular pyrimidine-2,4-diamines, analogues and salts thereof and pharmaceutical compositions comprising pyrimidine-2,4-diamines analogues and salts thereof for use in the treatment and prevention of a disease, in particular a growth hormone receptor-dependent condition. The invention also relates to methods of using these compounds and compositions to treat physiological disorders related to the amount or activity of growth hormone. In a particular embodiment, the invention relates to a compound according to formula 1 for use in the treatment or prevention of a disease in a subject.
L'invention concerne des composés, en particulier des pyrimidine-2,4-diamines, des analogues et des sels de ceux-ci et des compositions pharmaceutiques comprenant des analogues des pyrimidine-2,4-diamines et des sels de ceux-ci destinés à être utilisés dans le traitement et la prévention d'une maladie, en particulier d'une affection dépendant du récepteur de l'hormone de croissance. L'invention concerne également des méthodes d'utilisation de ces composés et compositions pour traiter des troubles physiologiques liés à la quantité ou à l'activité de l'hormone de croissance. Dans un mode de réalisation particulier, l'invention concerne un composé selon la formule 1 destiné à être utilisé dans le traitement ou la prévention d'une maladie chez un sujet. (Formule 1)</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAOdvVxdQ7xDHNVCPD3iQxwDQjxdHFVCI70C_FwDfYMVggOcfTx8fRzV3AMDnaMVHD0c1Fw9vcN8A_1c-FhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfHh_kYGRoYG5haWlqaOhsbEqQIAvs0qvA</recordid><startdate>20210429</startdate><enddate>20210429</enddate><creator>PIET, Dennis Patrick</creator><creator>VAN DER VELDEN, Lieke Marie</creator><creator>STROUS, Gerardus Jacobus Antonius Maria</creator><creator>MOL, Jan Adrianus</creator><creator>KLUMPERMAN, Judith</creator><creator>TIJHUIS, Johann Heinrich</creator><creator>VIÉTOR, Hendrik Engelbertus</creator><creator>DE KLERK-SPRENKELS, Nanda.Elisabeth</creator><creator>VAN DER KRIFT, Felix</creator><creator>MAAS, Petrus Emmanuel Marie</creator><creator>MAURICE, Madelon Maria</creator><scope>EVB</scope></search><sort><creationdate>20210429</creationdate><title>SELECTIVE POLYPEPTIDE SYNTHESIS STALLING ASSAY AND COMPOUND</title><author>PIET, Dennis Patrick ; VAN DER VELDEN, Lieke Marie ; STROUS, Gerardus Jacobus Antonius Maria ; MOL, Jan Adrianus ; KLUMPERMAN, Judith ; TIJHUIS, Johann Heinrich ; VIÉTOR, Hendrik Engelbertus ; DE KLERK-SPRENKELS, Nanda.Elisabeth ; VAN DER KRIFT, Felix ; MAAS, Petrus Emmanuel Marie ; MAURICE, Madelon Maria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2021078995A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2021</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>PIET, Dennis Patrick</creatorcontrib><creatorcontrib>VAN DER VELDEN, Lieke Marie</creatorcontrib><creatorcontrib>STROUS, Gerardus Jacobus Antonius Maria</creatorcontrib><creatorcontrib>MOL, Jan Adrianus</creatorcontrib><creatorcontrib>KLUMPERMAN, Judith</creatorcontrib><creatorcontrib>TIJHUIS, Johann Heinrich</creatorcontrib><creatorcontrib>VIÉTOR, Hendrik Engelbertus</creatorcontrib><creatorcontrib>DE KLERK-SPRENKELS, Nanda.Elisabeth</creatorcontrib><creatorcontrib>VAN DER KRIFT, Felix</creatorcontrib><creatorcontrib>MAAS, Petrus Emmanuel Marie</creatorcontrib><creatorcontrib>MAURICE, Madelon Maria</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PIET, Dennis Patrick</au><au>VAN DER VELDEN, Lieke Marie</au><au>STROUS, Gerardus Jacobus Antonius Maria</au><au>MOL, Jan Adrianus</au><au>KLUMPERMAN, Judith</au><au>TIJHUIS, Johann Heinrich</au><au>VIÉTOR, Hendrik Engelbertus</au><au>DE KLERK-SPRENKELS, Nanda.Elisabeth</au><au>VAN DER KRIFT, Felix</au><au>MAAS, Petrus Emmanuel Marie</au><au>MAURICE, Madelon Maria</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SELECTIVE POLYPEPTIDE SYNTHESIS STALLING ASSAY AND COMPOUND</title><date>2021-04-29</date><risdate>2021</risdate><abstract>The invention relates to compounds, in particular pyrimidine-2,4-diamines, analogues and salts thereof and pharmaceutical compositions comprising pyrimidine-2,4-diamines analogues and salts thereof for use in the treatment and prevention of a disease, in particular a growth hormone receptor-dependent condition. The invention also relates to methods of using these compounds and compositions to treat physiological disorders related to the amount or activity of growth hormone. In a particular embodiment, the invention relates to a compound according to formula 1 for use in the treatment or prevention of a disease in a subject.
L'invention concerne des composés, en particulier des pyrimidine-2,4-diamines, des analogues et des sels de ceux-ci et des compositions pharmaceutiques comprenant des analogues des pyrimidine-2,4-diamines et des sels de ceux-ci destinés à être utilisés dans le traitement et la prévention d'une maladie, en particulier d'une affection dépendant du récepteur de l'hormone de croissance. L'invention concerne également des méthodes d'utilisation de ces composés et compositions pour traiter des troubles physiologiques liés à la quantité ou à l'activité de l'hormone de croissance. Dans un mode de réalisation particulier, l'invention concerne un composé selon la formule 1 destiné à être utilisé dans le traitement ou la prévention d'une maladie chez un sujet. (Formule 1)</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | SELECTIVE POLYPEPTIDE SYNTHESIS STALLING ASSAY AND COMPOUND |
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