METHODS FOR RECOVERING MEVALONIC ACID OR SALTS OR LACTONES THEREOF FROM AQUEOUS SOLUTIONS USING WATER SOLVENT CRYSTALLIZATION AND COMPOSITIONS THEREOF
Compositions and methods are provided for producing crystalline forms of organic acids or salts or lactones thereof from an aqueous solution. More specifically, methods are provided for producing a crystalline form of a salt of mevalonic acid (also referred to as X-MVA) from an aqueous solution, com...
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| creator | NURMI, Juha WHITED, Gregory M JÄRVINEN, Juho KOIVIKKO, Hannu MENTUNEN, Tero Tuomas KUUSISTO, Jyrki SÄRELÄ, Pertti Matias SIITONEN, Jani |
| description | Compositions and methods are provided for producing crystalline forms of organic acids or salts or lactones thereof from an aqueous solution. More specifically, methods are provided for producing a crystalline form of a salt of mevalonic acid (also referred to as X-MVA) from an aqueous solution, comprising subjecting the aqueous solution comprising said X-MVA to a purification step to produce a purified solution and crystallizing said X-MVA from said purified solution by water solvent crystallization. Methods are also provided for producing mevalonolactone from an aqueous solution comprising X-MVA, comprising subjecting the aqueous solution comprising said X-MVA to cation exchange thereby converting said aqueous solution comprising X-MVA to an aqueous solution comprising mevalonolactone (MVL). Methods are also provided for producing mevalonolactone monohydrate crystals.
L'invention concerne des compositions et des procédés de production de formes cristallines d'acides organiques ou de leurs sels ou lactones à partir d'une solution aqueuse. Plus particulièrement, l'invention concerne des procédés de production d'une forme cristalline d'un sel d'acide mévalonique (également désigné par X-MVA) à partir d'une solution aqueuse, consistant à soumettre la solution aqueuse comprenant ledit X-MVA à une étape de purification pour produire une solution purifiée et à cristalliser ledit X-MVA issu de ladite solution purifiée par cristallisation par solvant à l'eau. L'invention concerne également des procédés de production de mévalonolactone à partir d'une solution aqueuse comprenant le X-MVA, consistant à soumettre la solution aqueuse comprenant ledit X-MVA à un échange cationique, ce qui permet de convertir ladite solution aqueuse comprenant le X-MVA en une solution aqueuse comprenant de la mévalonolactone (MVL). L'invention concerne également des procédés de production de cristaux de monohydrate de mévalonolactone. |
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L'invention concerne des compositions et des procédés de production de formes cristallines d'acides organiques ou de leurs sels ou lactones à partir d'une solution aqueuse. Plus particulièrement, l'invention concerne des procédés de production d'une forme cristalline d'un sel d'acide mévalonique (également désigné par X-MVA) à partir d'une solution aqueuse, consistant à soumettre la solution aqueuse comprenant ledit X-MVA à une étape de purification pour produire une solution purifiée et à cristalliser ledit X-MVA issu de ladite solution purifiée par cristallisation par solvant à l'eau. L'invention concerne également des procédés de production de mévalonolactone à partir d'une solution aqueuse comprenant le X-MVA, consistant à soumettre la solution aqueuse comprenant ledit X-MVA à un échange cationique, ce qui permet de convertir ladite solution aqueuse comprenant le X-MVA en une solution aqueuse comprenant de la mévalonolactone (MVL). L'invention concerne également des procédés de production de cristaux de monohydrate de mévalonolactone.</description><language>eng ; fre</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY ; CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PERFORMING OPERATIONS ; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SEPARATION ; THEIR RELEVANT APPARATUS ; TRANSPORTING</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210304&DB=EPODOC&CC=WO&NR=2021041361A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210304&DB=EPODOC&CC=WO&NR=2021041361A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>NURMI, Juha</creatorcontrib><creatorcontrib>WHITED, Gregory M</creatorcontrib><creatorcontrib>JÄRVINEN, Juho</creatorcontrib><creatorcontrib>KOIVIKKO, Hannu</creatorcontrib><creatorcontrib>MENTUNEN, Tero Tuomas</creatorcontrib><creatorcontrib>KUUSISTO, Jyrki</creatorcontrib><creatorcontrib>SÄRELÄ, Pertti Matias</creatorcontrib><creatorcontrib>SIITONEN, Jani</creatorcontrib><title>METHODS FOR RECOVERING MEVALONIC ACID OR SALTS OR LACTONES THEREOF FROM AQUEOUS SOLUTIONS USING WATER SOLVENT CRYSTALLIZATION AND COMPOSITIONS THEREOF</title><description>Compositions and methods are provided for producing crystalline forms of organic acids or salts or lactones thereof from an aqueous solution. More specifically, methods are provided for producing a crystalline form of a salt of mevalonic acid (also referred to as X-MVA) from an aqueous solution, comprising subjecting the aqueous solution comprising said X-MVA to a purification step to produce a purified solution and crystallizing said X-MVA from said purified solution by water solvent crystallization. Methods are also provided for producing mevalonolactone from an aqueous solution comprising X-MVA, comprising subjecting the aqueous solution comprising said X-MVA to cation exchange thereby converting said aqueous solution comprising X-MVA to an aqueous solution comprising mevalonolactone (MVL). Methods are also provided for producing mevalonolactone monohydrate crystals.
L'invention concerne des compositions et des procédés de production de formes cristallines d'acides organiques ou de leurs sels ou lactones à partir d'une solution aqueuse. Plus particulièrement, l'invention concerne des procédés de production d'une forme cristalline d'un sel d'acide mévalonique (également désigné par X-MVA) à partir d'une solution aqueuse, consistant à soumettre la solution aqueuse comprenant ledit X-MVA à une étape de purification pour produire une solution purifiée et à cristalliser ledit X-MVA issu de ladite solution purifiée par cristallisation par solvant à l'eau. L'invention concerne également des procédés de production de mévalonolactone à partir d'une solution aqueuse comprenant le X-MVA, consistant à soumettre la solution aqueuse comprenant ledit X-MVA à un échange cationique, ce qui permet de convertir ladite solution aqueuse comprenant le X-MVA en une solution aqueuse comprenant de la mévalonolactone (MVL). L'invention concerne également des procédés de production de cristaux de monohydrate de mévalonolactone.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PERFORMING OPERATIONS</subject><subject>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SEPARATION</subject><subject>THEIR RELEVANT APPARATUS</subject><subject>TRANSPORTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjL0KwkAQhNNYiPoOC9ZCfsR-uWzMweVWbzcRbSTIWYkK-iw-rwZ9AKsZZr6ZcfJqSGsuBSoOEMhwR8H6NTTUoWNvDaCxJXxKQacyGIdG2ZOA1hSIK6gCN4DblrgVEHatWvYCrQxHO1QKQ9qRVzBhL4rO2QMOEKAvwXCzYbHf0e9zmozO_eURZz-dJPOK1NSLeL8d4-Pen-I1Po87ztM8S5dZscowK_6j3lZmQ_A</recordid><startdate>20210304</startdate><enddate>20210304</enddate><creator>NURMI, Juha</creator><creator>WHITED, Gregory M</creator><creator>JÄRVINEN, Juho</creator><creator>KOIVIKKO, Hannu</creator><creator>MENTUNEN, Tero Tuomas</creator><creator>KUUSISTO, Jyrki</creator><creator>SÄRELÄ, Pertti Matias</creator><creator>SIITONEN, Jani</creator><scope>EVB</scope></search><sort><creationdate>20210304</creationdate><title>METHODS FOR RECOVERING MEVALONIC ACID OR SALTS OR LACTONES THEREOF FROM AQUEOUS SOLUTIONS USING WATER SOLVENT CRYSTALLIZATION AND COMPOSITIONS THEREOF</title><author>NURMI, Juha ; WHITED, Gregory M ; JÄRVINEN, Juho ; KOIVIKKO, Hannu ; MENTUNEN, Tero Tuomas ; KUUSISTO, Jyrki ; SÄRELÄ, Pertti Matias ; SIITONEN, Jani</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2021041361A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2021</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PERFORMING OPERATIONS</topic><topic>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SEPARATION</topic><topic>THEIR RELEVANT APPARATUS</topic><topic>TRANSPORTING</topic><toplevel>online_resources</toplevel><creatorcontrib>NURMI, Juha</creatorcontrib><creatorcontrib>WHITED, Gregory M</creatorcontrib><creatorcontrib>JÄRVINEN, Juho</creatorcontrib><creatorcontrib>KOIVIKKO, Hannu</creatorcontrib><creatorcontrib>MENTUNEN, Tero Tuomas</creatorcontrib><creatorcontrib>KUUSISTO, Jyrki</creatorcontrib><creatorcontrib>SÄRELÄ, Pertti Matias</creatorcontrib><creatorcontrib>SIITONEN, Jani</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>NURMI, Juha</au><au>WHITED, Gregory M</au><au>JÄRVINEN, Juho</au><au>KOIVIKKO, Hannu</au><au>MENTUNEN, Tero Tuomas</au><au>KUUSISTO, Jyrki</au><au>SÄRELÄ, Pertti Matias</au><au>SIITONEN, Jani</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHODS FOR RECOVERING MEVALONIC ACID OR SALTS OR LACTONES THEREOF FROM AQUEOUS SOLUTIONS USING WATER SOLVENT CRYSTALLIZATION AND COMPOSITIONS THEREOF</title><date>2021-03-04</date><risdate>2021</risdate><abstract>Compositions and methods are provided for producing crystalline forms of organic acids or salts or lactones thereof from an aqueous solution. More specifically, methods are provided for producing a crystalline form of a salt of mevalonic acid (also referred to as X-MVA) from an aqueous solution, comprising subjecting the aqueous solution comprising said X-MVA to a purification step to produce a purified solution and crystallizing said X-MVA from said purified solution by water solvent crystallization. Methods are also provided for producing mevalonolactone from an aqueous solution comprising X-MVA, comprising subjecting the aqueous solution comprising said X-MVA to cation exchange thereby converting said aqueous solution comprising X-MVA to an aqueous solution comprising mevalonolactone (MVL). Methods are also provided for producing mevalonolactone monohydrate crystals.
L'invention concerne des compositions et des procédés de production de formes cristallines d'acides organiques ou de leurs sels ou lactones à partir d'une solution aqueuse. Plus particulièrement, l'invention concerne des procédés de production d'une forme cristalline d'un sel d'acide mévalonique (également désigné par X-MVA) à partir d'une solution aqueuse, consistant à soumettre la solution aqueuse comprenant ledit X-MVA à une étape de purification pour produire une solution purifiée et à cristalliser ledit X-MVA issu de ladite solution purifiée par cristallisation par solvant à l'eau. L'invention concerne également des procédés de production de mévalonolactone à partir d'une solution aqueuse comprenant le X-MVA, consistant à soumettre la solution aqueuse comprenant ledit X-MVA à un échange cationique, ce qui permet de convertir ladite solution aqueuse comprenant le X-MVA en une solution aqueuse comprenant de la mévalonolactone (MVL). L'invention concerne également des procédés de production de cristaux de monohydrate de mévalonolactone.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SEPARATION THEIR RELEVANT APPARATUS TRANSPORTING |
| title | METHODS FOR RECOVERING MEVALONIC ACID OR SALTS OR LACTONES THEREOF FROM AQUEOUS SOLUTIONS USING WATER SOLVENT CRYSTALLIZATION AND COMPOSITIONS THEREOF |
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