METHODS OF TREATING INFECTIONS BY BLOCKING PATHOGEN MIMICS OF CD47

Methods are provided for treating a subject for an infection by a pathogen expressing a CD47-like mimic protein on its surface. In particular, the methods comprise administering an agent that reduces the binding of the CD47 mimic protein on the pathogen to SIRPα on a phagocytic cell, wherein the age...

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Hauptverfasser:	WEISSMAN, Irving L, BASTOUNIS, Effie, RAVEH, Tal Bachar, TAL, Michal Caspi, DULGEROFF, Laughing Bear Torrez, SHOHAM, Maia, ZARO, Balyn, HSU, Joe, MATTHALOU, Efthymia, MARKOVIC, Maxim
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Methods are provided for treating a subject for an infection by a pathogen expressing a CD47-like mimic protein on its surface. In particular, the methods comprise administering an agent that reduces the binding of the CD47 mimic protein on the pathogen to SIRPα on a phagocytic cell, wherein the agent is administered at an effective dose for increasing phagocytosis of the pathogen. L'invention concerne des procédés de traitement d'un sujet contre une infection par un pathogène exprimant une protéine mimétique de type CD47 sur sa surface. En particulier, les procédés comprennent l'administration d'un agent qui réduit la liaison de la protéine mimétique de CD47 sur le pathogène à SIRPα sur une cellule phagocytaire, l'agent étant administré en une dose efficace pour augmenter la phagocytose du pathogène.