GENE THERAPY FOR EYE PATHOLOGIES

Compositions and methods are described for the delivery of therapeutic products (such as therapeutic proteins (for example, antibodies), therapeutic RNAs (for example, shRNAs, siRNAs, and miRNAs), and therapeutic aptamers) to the retina/vitreal humour in the eyes of human subjects to treat pathologi...

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Hauptverfasser: DANOS, Olivier, YOO, Jesse, CURTISS, Darin, VAN EVEREN, Sherri, IRWIN-PACK, Kim, GHANEKAR, Avanti, O'BERRY, Anthony, PATEL, Samir
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creator DANOS, Olivier
YOO, Jesse
CURTISS, Darin
VAN EVEREN, Sherri
IRWIN-PACK, Kim
GHANEKAR, Avanti
O'BERRY, Anthony
PATEL, Samir
description Compositions and methods are described for the delivery of therapeutic products (such as therapeutic proteins (for example, antibodies), therapeutic RNAs (for example, shRNAs, siRNAs, and miRNAs), and therapeutic aptamers) to the retina/vitreal humour in the eyes of human subjects to treat pathologies of the eye, involving, for example, recombinant viral vectors such as recombinant adeno-associated virus (rAAV) vectors. L'invention concerne des compositions et des méthodes destinées à l'administration de produits thérapeutiques (tels que des protéines thérapeutiques (par exemple, des anticorps), des ARN thérapeutiques (par exemple, ARNsi, des ARNsh et des miARN), et des aptamères thérapeutiques) dans la rétine/l'humeur vitrée des yeux de sujets humains pour traiter des pathologies de l'œil, impliquant, par exemple, des vecteurs viraux recombinés tels que des vecteurs de virus adéno-associés recombinés (rAAV).
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subjects BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
title GENE THERAPY FOR EYE PATHOLOGIES
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