HETEROARYLMETHYLENE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS
Disclosed herein are certain acetamido derivatives that are DNA Polymerase Theta (Polθ) inhibitors of Formula (I). Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of Polθ such as cancer, including homologous recombina...
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| creator | DILLON, Michael JONES, Brian MARTINEZ, Luisruben P BECK, Hilary Plake |
| description | Disclosed herein are certain acetamido derivatives that are DNA Polymerase Theta (Polθ) inhibitors of Formula (I). Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.
L'invention concerne certains dérivés acétamido qui sont des inhibiteurs d'ADN polymérase thêta (Polθ) de formule (I). L'invention concerne également des compositions pharmaceutiques comprenant de tels composés et des méthodes de traitement de maladies pouvant être traitées par inhibition de Polθ telles que le cancer, y compris des cancers déficients en recombinaison homologue (HR). |
| format | Patent |
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L'invention concerne certains dérivés acétamido qui sont des inhibiteurs d'ADN polymérase thêta (Polθ) de formule (I). L'invention concerne également des compositions pharmaceutiques comprenant de tels composés et des méthodes de traitement de maladies pouvant être traitées par inhibition de Polθ telles que le cancer, y compris des cancers déficients en recombinaison homologue (HR).</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200806&DB=EPODOC&CC=WO&NR=2020160213A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200806&DB=EPODOC&CC=WO&NR=2020160213A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DILLON, Michael</creatorcontrib><creatorcontrib>JONES, Brian</creatorcontrib><creatorcontrib>MARTINEZ, Luisruben P</creatorcontrib><creatorcontrib>BECK, Hilary Plake</creatorcontrib><title>HETEROARYLMETHYLENE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS</title><description>Disclosed herein are certain acetamido derivatives that are DNA Polymerase Theta (Polθ) inhibitors of Formula (I). Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.
L'invention concerne certains dérivés acétamido qui sont des inhibiteurs d'ADN polymérase thêta (Polθ) de formule (I). L'invention concerne également des compositions pharmaceutiques comprenant de tels composés et des méthodes de traitement de maladies pouvant être traitées par inhibition de Polθ telles que le cancer, y compris des cancers déficients en recombinaison homologue (HR).</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHDycA1xDfJ3DIr08XUN8Yj0cfVzVXBxDfIMcwzxDHMNVnAMVnDxc1QI8PeJ9HUNcgx2VQgBanFU8PTz8HTyDPEPCuZhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfHh_kYGRgaGZgZGhsaOhsbEqQIA7-QshA</recordid><startdate>20200806</startdate><enddate>20200806</enddate><creator>DILLON, Michael</creator><creator>JONES, Brian</creator><creator>MARTINEZ, Luisruben P</creator><creator>BECK, Hilary Plake</creator><scope>EVB</scope></search><sort><creationdate>20200806</creationdate><title>HETEROARYLMETHYLENE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS</title><author>DILLON, Michael ; JONES, Brian ; MARTINEZ, Luisruben P ; BECK, Hilary Plake</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2020160213A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2020</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>DILLON, Michael</creatorcontrib><creatorcontrib>JONES, Brian</creatorcontrib><creatorcontrib>MARTINEZ, Luisruben P</creatorcontrib><creatorcontrib>BECK, Hilary Plake</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DILLON, Michael</au><au>JONES, Brian</au><au>MARTINEZ, Luisruben P</au><au>BECK, Hilary Plake</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>HETEROARYLMETHYLENE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS</title><date>2020-08-06</date><risdate>2020</risdate><abstract>Disclosed herein are certain acetamido derivatives that are DNA Polymerase Theta (Polθ) inhibitors of Formula (I). Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.
L'invention concerne certains dérivés acétamido qui sont des inhibiteurs d'ADN polymérase thêta (Polθ) de formule (I). L'invention concerne également des compositions pharmaceutiques comprenant de tels composés et des méthodes de traitement de maladies pouvant être traitées par inhibition de Polθ telles que le cancer, y compris des cancers déficients en recombinaison homologue (HR).</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | HETEROARYLMETHYLENE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS |
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