A SUSTAINED RELEASE COMPOSITION COMPRISING A HYDROXYALKYL METHYLCELLULOSE
A sustained release composition for oral administration comprises particles of a physiologically active ingredient mixed with a hydroxyalkyl methylcellulose, wherein the ether substituents are methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl, the hydroxyalk...
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| creator | PETERMANN, Oliver O |
| description | A sustained release composition for oral administration comprises particles of a physiologically active ingredient mixed with a hydroxyalkyl methylcellulose, wherein the ether substituents are methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl, the hydroxyalkyl methylcellulose has an MS(hydroxyalkyl) of 0.05 to 1.00, and hydroxy groups of anhydroglucose units are substituted with methyl groups such that [ s23/s26 - 0.2*MS(hydroxyalkyl)] is 0.30 or less, and wherein the concentration of hydroxyalkyl methylcellulose is 0.1-10% by dry weight of the active ingredient.
L'invention concerne une composition à libération prolongée pour une administration orale qui comprend des particules d'un principe physiologiquement actif mélangé à une méthylcellulose hydroxyalkyle, les substituants éther étant des groupes méthyle, des groupes hydroxyalkyle et éventuellement des groupes alkyle différents du méthyle, la méthylcellulose hydroxyalkyle ayant une valeur MS (hydroxyalkyle) située entre 0,05 et 1,00, et des groupes hydroxy d'unités anhydroglucose étant substitués par des groupes méthyle de telle sorte que [s23/s26 - 0,2 * MS(hydroxyalkyle)] est de 0,30 ou moins, et la concentration de méthylcellulose hydroxyalkyle étant située entre 0,1 et 10 % en poids sec du principe actif. |
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L'invention concerne une composition à libération prolongée pour une administration orale qui comprend des particules d'un principe physiologiquement actif mélangé à une méthylcellulose hydroxyalkyle, les substituants éther étant des groupes méthyle, des groupes hydroxyalkyle et éventuellement des groupes alkyle différents du méthyle, la méthylcellulose hydroxyalkyle ayant une valeur MS (hydroxyalkyle) située entre 0,05 et 1,00, et des groupes hydroxy d'unités anhydroglucose étant substitués par des groupes méthyle de telle sorte que [s23/s26 - 0,2 * MS(hydroxyalkyle)] est de 0,30 ou moins, et la concentration de méthylcellulose hydroxyalkyle étant située entre 0,1 et 10 % en poids sec du principe actif.</description><language>eng ; fre</language><subject>CHEMISTRY ; COMPOSITIONS BASED THEREON ; DERIVATIVES THEREOF ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC MACROMOLECULAR COMPOUNDS ; POLYSACCHARIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200625&DB=EPODOC&CC=WO&NR=2020131795A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25547,76298</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200625&DB=EPODOC&CC=WO&NR=2020131795A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PETERMANN, Oliver O</creatorcontrib><title>A SUSTAINED RELEASE COMPOSITION COMPRISING A HYDROXYALKYL METHYLCELLULOSE</title><description>A sustained release composition for oral administration comprises particles of a physiologically active ingredient mixed with a hydroxyalkyl methylcellulose, wherein the ether substituents are methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl, the hydroxyalkyl methylcellulose has an MS(hydroxyalkyl) of 0.05 to 1.00, and hydroxy groups of anhydroglucose units are substituted with methyl groups such that [ s23/s26 - 0.2*MS(hydroxyalkyl)] is 0.30 or less, and wherein the concentration of hydroxyalkyl methylcellulose is 0.1-10% by dry weight of the active ingredient.
L'invention concerne une composition à libération prolongée pour une administration orale qui comprend des particules d'un principe physiologiquement actif mélangé à une méthylcellulose hydroxyalkyle, les substituants éther étant des groupes méthyle, des groupes hydroxyalkyle et éventuellement des groupes alkyle différents du méthyle, la méthylcellulose hydroxyalkyle ayant une valeur MS (hydroxyalkyle) située entre 0,05 et 1,00, et des groupes hydroxy d'unités anhydroglucose étant substitués par des groupes méthyle de telle sorte que [s23/s26 - 0,2 * MS(hydroxyalkyle)] est de 0,30 ou moins, et la concentration de méthylcellulose hydroxyalkyle étant située entre 0,1 et 10 % en poids sec du principe actif.</description><subject>CHEMISTRY</subject><subject>COMPOSITIONS BASED THEREON</subject><subject>DERIVATIVES THEREOF</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC MACROMOLECULAR COMPOUNDS</subject><subject>POLYSACCHARIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPB0VAgODQ5x9PRzdVEIcvVxdQx2VXD29w3wD_YM8fT3A7ODPIM9_dwVHBU8Il2C_CMiHX28I30UfF1DPCJ9nF19fEJ9_INdeRhY0xJzilN5oTQ3g7Kba4izh25qQX58anFBYnJqXmpJfLi_kYGRgaGxobmlqaOhMXGqAC4cLq0</recordid><startdate>20200625</startdate><enddate>20200625</enddate><creator>PETERMANN, Oliver O</creator><scope>EVB</scope></search><sort><creationdate>20200625</creationdate><title>A SUSTAINED RELEASE COMPOSITION COMPRISING A HYDROXYALKYL METHYLCELLULOSE</title><author>PETERMANN, Oliver O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2020131795A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2020</creationdate><topic>CHEMISTRY</topic><topic>COMPOSITIONS BASED THEREON</topic><topic>DERIVATIVES THEREOF</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC MACROMOLECULAR COMPOUNDS</topic><topic>POLYSACCHARIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>THEIR PREPARATION OR CHEMICAL WORKING-UP</topic><toplevel>online_resources</toplevel><creatorcontrib>PETERMANN, Oliver O</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PETERMANN, Oliver O</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>A SUSTAINED RELEASE COMPOSITION COMPRISING A HYDROXYALKYL METHYLCELLULOSE</title><date>2020-06-25</date><risdate>2020</risdate><abstract>A sustained release composition for oral administration comprises particles of a physiologically active ingredient mixed with a hydroxyalkyl methylcellulose, wherein the ether substituents are methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl, the hydroxyalkyl methylcellulose has an MS(hydroxyalkyl) of 0.05 to 1.00, and hydroxy groups of anhydroglucose units are substituted with methyl groups such that [ s23/s26 - 0.2*MS(hydroxyalkyl)] is 0.30 or less, and wherein the concentration of hydroxyalkyl methylcellulose is 0.1-10% by dry weight of the active ingredient.
L'invention concerne une composition à libération prolongée pour une administration orale qui comprend des particules d'un principe physiologiquement actif mélangé à une méthylcellulose hydroxyalkyle, les substituants éther étant des groupes méthyle, des groupes hydroxyalkyle et éventuellement des groupes alkyle différents du méthyle, la méthylcellulose hydroxyalkyle ayant une valeur MS (hydroxyalkyle) située entre 0,05 et 1,00, et des groupes hydroxy d'unités anhydroglucose étant substitués par des groupes méthyle de telle sorte que [s23/s26 - 0,2 * MS(hydroxyalkyle)] est de 0,30 ou moins, et la concentration de méthylcellulose hydroxyalkyle étant située entre 0,1 et 10 % en poids sec du principe actif.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY COMPOSITIONS BASED THEREON DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS POLYSACCHARIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR PREPARATION OR CHEMICAL WORKING-UP |
| title | A SUSTAINED RELEASE COMPOSITION COMPRISING A HYDROXYALKYL METHYLCELLULOSE |
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