LIPOPEPTIDE BUILDING BLOCKS AND SYNTHETIC VIRUS-LIKE PARTICLES

The present invention relates to a lipopeptide building block consisting of (i) a peptide moiety comprising a coiled coil peptide chain segment, wherein said coiled coil peptide chain segment comprises 3 to 8 repeat units, and wherein said repeat unit consists of the sequence IEKKIE-XO (SEQ ID NO:58), wherein X0 represents an amino acid, and wherein preferably said repeat unit consists of the sequence selected from IEKKIEG (SEQ ID NO:59), IEKKIEA (SEQ ID NO:12) or IEKKIES (SEQ ID NO:13), and wherein further preferably said repeat unit consists of the sequence IEKKIES (SEQ ID NO:13); (ii) a lipid moiety comprising, preferably consisting of, the formula LM-I wherein R1 and R2 are independently C11-15alkyl, wherein preferably R1 and R2 are independently -C11H23, -C13H27 or -C15H31, and wherein further preferably R1 and R2 are -C15H31; and wherein R3 is hydrogen or -C(O)C11-15alkyl, and wherein preferably R3 is H or -C(O)C15H31; and wherein said lipid moiety is linked to said peptide moiety, wherein the wavy line in formula LM-I indicates the linkage site to said peptide moiety, and wherein preferably said lipid moiety is linked to the N-terminus of said peptide moiety, as well as conjugates comprising said lipopeptide building blocks to which antigens are coupled, bundles of such conjugates, synthetic virus -like particles (SVLPs) comprising at least one bundle of conjugates and pharmaceutical compositions comprising the same. The present invention further relates to said conjugates, bundles of conjugates, said SVLPs and said pharmaceutical compositions for use as a medicament, as vaccines and for use in methods of preventing or treating a disease, preferably selected from infectious diseases, allergies and cancer, and generally to efficiently induce antigen specific immune responses. La présente invention concerne un bloc de construction de lipopeptide constitué (i) d'une fraction peptidique comprenant un segment de chaîne peptidique enroulée en superhélice, ledit segment de chaîne peptidique enroulée en superhélice comprenant de 3 à 8 unités de répétition, et ladite unité de répétition étant constituée de la séquence IEKKIE-XO (SEQ ID NO:58), où X0 représente un acide aminé, et de préférence ladite unité de répétition est constituée de la séquence choisie parmi IEKKIEG (SEQ ID NO:59), IEKKIEA (SEQ ID NO:12) ou IEKKIES (SEQ ID NO:13), et de préférence ladite unité de répétition étant constituée de la séquence IEKKIES (SEQ ID NO:13) ; (ii) d'une fraction lipi