FERROPORTIN INHIBITORS AND METHODS OF USE
The subject matter described herein is directed to Ferroportin inhibitor compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for prophylaxis and/or treatment of di...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | RADEMACHER, Peter Michael ALT, Carsten XU, Qing YEE, Calvin Wesley LI, Zhe METCALF, Brian Walter |
| description | The subject matter described herein is directed to Ferroportin inhibitor compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis.
L'invention concerne des composés inhibiteurs de ferroportine de formule I et des sels pharmaceutiques de ceux-ci, des procédés de préparation des composés, des compositions pharmaceutiques comprenant les composés et des procédés d'administration des composés pour la prophylaxie et/ou le traitement de maladies provoquées par un manque d'hepcidine ou des troubles du métabolisme du fer, en particulier des états de surcharge en fer, tels que la thalassémie, la drépanocytose et l'hémochromatose. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO2020123850A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO2020123850A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO2020123850A13</originalsourceid><addsrcrecordid>eNrjZNB0cw0K8g_wDwrx9FPw9PPwdPIM8Q8KVnD0c1HwdQ3x8HcJVvB3UwgNduVhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfHh_kYGRgaGRsYWpgaOhsbEqQIAyr8lTA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>FERROPORTIN INHIBITORS AND METHODS OF USE</title><source>esp@cenet</source><creator>RADEMACHER, Peter Michael ; ALT, Carsten ; XU, Qing ; YEE, Calvin Wesley ; LI, Zhe ; METCALF, Brian Walter</creator><creatorcontrib>RADEMACHER, Peter Michael ; ALT, Carsten ; XU, Qing ; YEE, Calvin Wesley ; LI, Zhe ; METCALF, Brian Walter</creatorcontrib><description>The subject matter described herein is directed to Ferroportin inhibitor compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis.
L'invention concerne des composés inhibiteurs de ferroportine de formule I et des sels pharmaceutiques de ceux-ci, des procédés de préparation des composés, des compositions pharmaceutiques comprenant les composés et des procédés d'administration des composés pour la prophylaxie et/ou le traitement de maladies provoquées par un manque d'hepcidine ou des troubles du métabolisme du fer, en particulier des états de surcharge en fer, tels que la thalassémie, la drépanocytose et l'hémochromatose.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200618&DB=EPODOC&CC=WO&NR=2020123850A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25568,76551</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200618&DB=EPODOC&CC=WO&NR=2020123850A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RADEMACHER, Peter Michael</creatorcontrib><creatorcontrib>ALT, Carsten</creatorcontrib><creatorcontrib>XU, Qing</creatorcontrib><creatorcontrib>YEE, Calvin Wesley</creatorcontrib><creatorcontrib>LI, Zhe</creatorcontrib><creatorcontrib>METCALF, Brian Walter</creatorcontrib><title>FERROPORTIN INHIBITORS AND METHODS OF USE</title><description>The subject matter described herein is directed to Ferroportin inhibitor compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis.
L'invention concerne des composés inhibiteurs de ferroportine de formule I et des sels pharmaceutiques de ceux-ci, des procédés de préparation des composés, des compositions pharmaceutiques comprenant les composés et des procédés d'administration des composés pour la prophylaxie et/ou le traitement de maladies provoquées par un manque d'hepcidine ou des troubles du métabolisme du fer, en particulier des états de surcharge en fer, tels que la thalassémie, la drépanocytose et l'hémochromatose.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNB0cw0K8g_wDwrx9FPw9PPwdPIM8Q8KVnD0c1HwdQ3x8HcJVvB3UwgNduVhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfHh_kYGRgaGRsYWpgaOhsbEqQIAyr8lTA</recordid><startdate>20200618</startdate><enddate>20200618</enddate><creator>RADEMACHER, Peter Michael</creator><creator>ALT, Carsten</creator><creator>XU, Qing</creator><creator>YEE, Calvin Wesley</creator><creator>LI, Zhe</creator><creator>METCALF, Brian Walter</creator><scope>EVB</scope></search><sort><creationdate>20200618</creationdate><title>FERROPORTIN INHIBITORS AND METHODS OF USE</title><author>RADEMACHER, Peter Michael ; ALT, Carsten ; XU, Qing ; YEE, Calvin Wesley ; LI, Zhe ; METCALF, Brian Walter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2020123850A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2020</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>RADEMACHER, Peter Michael</creatorcontrib><creatorcontrib>ALT, Carsten</creatorcontrib><creatorcontrib>XU, Qing</creatorcontrib><creatorcontrib>YEE, Calvin Wesley</creatorcontrib><creatorcontrib>LI, Zhe</creatorcontrib><creatorcontrib>METCALF, Brian Walter</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>RADEMACHER, Peter Michael</au><au>ALT, Carsten</au><au>XU, Qing</au><au>YEE, Calvin Wesley</au><au>LI, Zhe</au><au>METCALF, Brian Walter</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>FERROPORTIN INHIBITORS AND METHODS OF USE</title><date>2020-06-18</date><risdate>2020</risdate><abstract>The subject matter described herein is directed to Ferroportin inhibitor compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis.
L'invention concerne des composés inhibiteurs de ferroportine de formule I et des sels pharmaceutiques de ceux-ci, des procédés de préparation des composés, des compositions pharmaceutiques comprenant les composés et des procédés d'administration des composés pour la prophylaxie et/ou le traitement de maladies provoquées par un manque d'hepcidine ou des troubles du métabolisme du fer, en particulier des états de surcharge en fer, tels que la thalassémie, la drépanocytose et l'hémochromatose.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre |
| recordid | cdi_epo_espacenet_WO2020123850A1 |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | FERROPORTIN INHIBITORS AND METHODS OF USE |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T08%3A50%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=RADEMACHER,%20Peter%20Michael&rft.date=2020-06-18&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EWO2020123850A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |