FUSION PROTEIN CONSTRUCTS FOR COMPLEMENT ASSOCIATED DISEASE
Provided herein are fusion protein constructs that can bind a complement-associated antigen, comprising a targeting moiety and a complement modulator protein, or a fragment thereof or a variant thereof. The targeting moiety is an antibody or an antigen binding fragment thereof, in some examples. Fur...
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| creator | KALLED, Susan L VIOLETTE, Shelia Marie TAYLOR, Frederick Robbins CARAVELLA, Justin Andrew FAHNOE, Kelly C STARK, Ellen Garber STOREK, Michael HOLERS, Vernon Michael HUANG, Cheng Ran CURTIS, Michael Steven |
| description | Provided herein are fusion protein constructs that can bind a complement-associated antigen, comprising a targeting moiety and a complement modulator protein, or a fragment thereof or a variant thereof. The targeting moiety is an antibody or an antigen binding fragment thereof, in some examples. Further provided are methods of using the fusion protein constructs, for example, in treating complement mediation conditions.
L'invention concerne des constructions de protéine de fusion qui peuvent se lier à un antigène associé au complément, comprenant une fraction de ciblage et une protéine modulatrice du complément, ou un fragment de celle-ci ou un variant de celle-ci. La fraction de ciblage est un anticorps ou un fragment de liaison à l'antigène de celui-ci, dans certains exemples. L'invention concerne en outre des procédés d'utilisation des constructions de protéines de fusion, par exemple, dans le traitement d'états médiés par le complément. |
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L'invention concerne des constructions de protéine de fusion qui peuvent se lier à un antigène associé au complément, comprenant une fraction de ciblage et une protéine modulatrice du complément, ou un fragment de celle-ci ou un variant de celle-ci. La fraction de ciblage est un anticorps ou un fragment de liaison à l'antigène de celui-ci, dans certains exemples. L'invention concerne en outre des procédés d'utilisation des constructions de protéines de fusion, par exemple, dans le traitement d'états médiés par le complément.</description><language>eng ; fre</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200723&DB=EPODOC&CC=WO&NR=2020123662A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200723&DB=EPODOC&CC=WO&NR=2020123662A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KALLED, Susan L</creatorcontrib><creatorcontrib>VIOLETTE, Shelia Marie</creatorcontrib><creatorcontrib>TAYLOR, Frederick Robbins</creatorcontrib><creatorcontrib>CARAVELLA, Justin Andrew</creatorcontrib><creatorcontrib>FAHNOE, Kelly C</creatorcontrib><creatorcontrib>STARK, Ellen Garber</creatorcontrib><creatorcontrib>STOREK, Michael</creatorcontrib><creatorcontrib>HOLERS, Vernon Michael</creatorcontrib><creatorcontrib>HUANG, Cheng Ran</creatorcontrib><creatorcontrib>CURTIS, Michael Steven</creatorcontrib><title>FUSION PROTEIN CONSTRUCTS FOR COMPLEMENT ASSOCIATED DISEASE</title><description>Provided herein are fusion protein constructs that can bind a complement-associated antigen, comprising a targeting moiety and a complement modulator protein, or a fragment thereof or a variant thereof. The targeting moiety is an antibody or an antigen binding fragment thereof, in some examples. Further provided are methods of using the fusion protein constructs, for example, in treating complement mediation conditions.
L'invention concerne des constructions de protéine de fusion qui peuvent se lier à un antigène associé au complément, comprenant une fraction de ciblage et une protéine modulatrice du complément, ou un fragment de celle-ci ou un variant de celle-ci. La fraction de ciblage est un anticorps ou un fragment de liaison à l'antigène de celui-ci, dans certains exemples. L'invention concerne en outre des procédés d'utilisation des constructions de protéines de fusion, par exemple, dans le traitement d'états médiés par le complément.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLB2Cw329PdTCAjyD3H19FNw9vcLDgkKdQ4JVnDzDwJyfQN8XH1d_UIUHIOD_Z09HUNcXRRcPINdHYNdeRhY0xJzilN5oTQ3g7Kba4izh25qQX58anFBYnJqXmpJfLi_kYGRgaGRsZmZkaOxMXGqALTuKow</recordid><startdate>20200723</startdate><enddate>20200723</enddate><creator>KALLED, Susan L</creator><creator>VIOLETTE, Shelia Marie</creator><creator>TAYLOR, Frederick Robbins</creator><creator>CARAVELLA, Justin Andrew</creator><creator>FAHNOE, Kelly C</creator><creator>STARK, Ellen Garber</creator><creator>STOREK, Michael</creator><creator>HOLERS, Vernon Michael</creator><creator>HUANG, Cheng Ran</creator><creator>CURTIS, Michael Steven</creator><scope>EVB</scope></search><sort><creationdate>20200723</creationdate><title>FUSION PROTEIN CONSTRUCTS FOR COMPLEMENT ASSOCIATED DISEASE</title><author>KALLED, Susan L ; VIOLETTE, Shelia Marie ; TAYLOR, Frederick Robbins ; CARAVELLA, Justin Andrew ; FAHNOE, Kelly C ; STARK, Ellen Garber ; STOREK, Michael ; HOLERS, Vernon Michael ; HUANG, Cheng Ran ; CURTIS, Michael Steven</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2020123662A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2020</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>KALLED, Susan L</creatorcontrib><creatorcontrib>VIOLETTE, Shelia Marie</creatorcontrib><creatorcontrib>TAYLOR, Frederick Robbins</creatorcontrib><creatorcontrib>CARAVELLA, Justin Andrew</creatorcontrib><creatorcontrib>FAHNOE, Kelly C</creatorcontrib><creatorcontrib>STARK, Ellen Garber</creatorcontrib><creatorcontrib>STOREK, Michael</creatorcontrib><creatorcontrib>HOLERS, Vernon Michael</creatorcontrib><creatorcontrib>HUANG, Cheng Ran</creatorcontrib><creatorcontrib>CURTIS, Michael Steven</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KALLED, Susan L</au><au>VIOLETTE, Shelia Marie</au><au>TAYLOR, Frederick Robbins</au><au>CARAVELLA, Justin Andrew</au><au>FAHNOE, Kelly C</au><au>STARK, Ellen Garber</au><au>STOREK, Michael</au><au>HOLERS, Vernon Michael</au><au>HUANG, Cheng Ran</au><au>CURTIS, Michael Steven</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>FUSION PROTEIN CONSTRUCTS FOR COMPLEMENT ASSOCIATED DISEASE</title><date>2020-07-23</date><risdate>2020</risdate><abstract>Provided herein are fusion protein constructs that can bind a complement-associated antigen, comprising a targeting moiety and a complement modulator protein, or a fragment thereof or a variant thereof. The targeting moiety is an antibody or an antigen binding fragment thereof, in some examples. Further provided are methods of using the fusion protein constructs, for example, in treating complement mediation conditions.
L'invention concerne des constructions de protéine de fusion qui peuvent se lier à un antigène associé au complément, comprenant une fraction de ciblage et une protéine modulatrice du complément, ou un fragment de celle-ci ou un variant de celle-ci. La fraction de ciblage est un anticorps ou un fragment de liaison à l'antigène de celui-ci, dans certains exemples. L'invention concerne en outre des procédés d'utilisation des constructions de protéines de fusion, par exemple, dans le traitement d'états médiés par le complément.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | FUSION PROTEIN CONSTRUCTS FOR COMPLEMENT ASSOCIATED DISEASE |
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