PHARMACEUTICAL COMPOSITIONS COMPRISING ANTI-191P4D12 ANTIBODY DRUG CONJUGATES AND METHODS OF USE THEREOF
A pharmaceutical composition comprising an antibody drug conjugate comprising an antibody or antigen binding fragment thereof that binds to 191P4D12 conjugated to one or more units of monomethyl auri statin E (MMAE) and a pharmaceutically acceptable excipient comprising L-histidine, polysorbate-20 (...
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| creator | SUN, Yingqing MCGARVEY, Orla VAN SCHRAVENDIJK, Marie Rose RATNASWAMY, Gayathri |
| description | A pharmaceutical composition comprising an antibody drug conjugate comprising an antibody or antigen binding fragment thereof that binds to 191P4D12 conjugated to one or more units of monomethyl auri statin E (MMAE) and a pharmaceutically acceptable excipient comprising L-histidine, polysorbate-20 (TWEEN-20), and at least one of trehalose dihydrate and sucrose.
L'invention concerne une composition pharmaceutique qui comporte un conjugué anticorps-médicament qui comprend un anticorps, ou un fragment de liaison à l'antigène de celui-ci, qui se lie à la protéine 191P4D12, conjugué à une ou à plusieurs unités de la monométhylauristatine E (MMAE), ainsi qu'un excipient de qualité pharmaceutique qui comprend de la L-histidine, du polysorbate-20 (TWEEN-20) et au moins l'un des sucres dihydrate de tréhalose et saccharose. |
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L'invention concerne une composition pharmaceutique qui comporte un conjugué anticorps-médicament qui comprend un anticorps, ou un fragment de liaison à l'antigène de celui-ci, qui se lie à la protéine 191P4D12, conjugué à une ou à plusieurs unités de la monométhylauristatine E (MMAE), ainsi qu'un excipient de qualité pharmaceutique qui comprend de la L-histidine, du polysorbate-20 (TWEEN-20) et au moins l'un des sucres dihydrate de tréhalose et saccharose.</description><language>eng ; fre</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210218&DB=EPODOC&CC=WO&NR=2020117373A8$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210218&DB=EPODOC&CC=WO&NR=2020117373A8$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SUN, Yingqing</creatorcontrib><creatorcontrib>MCGARVEY, Orla</creatorcontrib><creatorcontrib>VAN SCHRAVENDIJK, Marie Rose</creatorcontrib><creatorcontrib>RATNASWAMY, Gayathri</creatorcontrib><title>PHARMACEUTICAL COMPOSITIONS COMPRISING ANTI-191P4D12 ANTIBODY DRUG CONJUGATES AND METHODS OF USE THEREOF</title><description>A pharmaceutical composition comprising an antibody drug conjugate comprising an antibody or antigen binding fragment thereof that binds to 191P4D12 conjugated to one or more units of monomethyl auri statin E (MMAE) and a pharmaceutically acceptable excipient comprising L-histidine, polysorbate-20 (TWEEN-20), and at least one of trehalose dihydrate and sucrose.
L'invention concerne une composition pharmaceutique qui comporte un conjugué anticorps-médicament qui comprend un anticorps, ou un fragment de liaison à l'antigène de celui-ci, qui se lie à la protéine 191P4D12, conjugué à une ou à plusieurs unités de la monométhylauristatine E (MMAE), ainsi qu'un excipient de qualité pharmaceutique qui comprend de la L-histidine, du polysorbate-20 (TWEEN-20) et au moins l'un des sucres dihydrate de tréhalose et saccharose.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNirEKwjAUALs4iPoPD5wLTStUx5ikTcTmleQFcSpFIg6ihfr_WIof4HQcd8vk0WruGi5UICP4GQQ2LXpDBq2fxRlvbA3ckknZgbU7yfLZjiivIF2op82eQs1J-SlIaBRplB6wguAVkFZOYbVOFvf-OcbNj6tkWykSOo3Du4vj0N_iK366C-ZZnjFWFmXB98V_1xfs0DZa</recordid><startdate>20210218</startdate><enddate>20210218</enddate><creator>SUN, Yingqing</creator><creator>MCGARVEY, Orla</creator><creator>VAN SCHRAVENDIJK, Marie Rose</creator><creator>RATNASWAMY, Gayathri</creator><scope>EVB</scope></search><sort><creationdate>20210218</creationdate><title>PHARMACEUTICAL COMPOSITIONS COMPRISING ANTI-191P4D12 ANTIBODY DRUG CONJUGATES AND METHODS OF USE THEREOF</title><author>SUN, Yingqing ; MCGARVEY, Orla ; VAN SCHRAVENDIJK, Marie Rose ; RATNASWAMY, Gayathri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2020117373A83</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2021</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>SUN, Yingqing</creatorcontrib><creatorcontrib>MCGARVEY, Orla</creatorcontrib><creatorcontrib>VAN SCHRAVENDIJK, Marie Rose</creatorcontrib><creatorcontrib>RATNASWAMY, Gayathri</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SUN, Yingqing</au><au>MCGARVEY, Orla</au><au>VAN SCHRAVENDIJK, Marie Rose</au><au>RATNASWAMY, Gayathri</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PHARMACEUTICAL COMPOSITIONS COMPRISING ANTI-191P4D12 ANTIBODY DRUG CONJUGATES AND METHODS OF USE THEREOF</title><date>2021-02-18</date><risdate>2021</risdate><abstract>A pharmaceutical composition comprising an antibody drug conjugate comprising an antibody or antigen binding fragment thereof that binds to 191P4D12 conjugated to one or more units of monomethyl auri statin E (MMAE) and a pharmaceutically acceptable excipient comprising L-histidine, polysorbate-20 (TWEEN-20), and at least one of trehalose dihydrate and sucrose.
L'invention concerne une composition pharmaceutique qui comporte un conjugué anticorps-médicament qui comprend un anticorps, ou un fragment de liaison à l'antigène de celui-ci, qui se lie à la protéine 191P4D12, conjugué à une ou à plusieurs unités de la monométhylauristatine E (MMAE), ainsi qu'un excipient de qualité pharmaceutique qui comprend de la L-histidine, du polysorbate-20 (TWEEN-20) et au moins l'un des sucres dihydrate de tréhalose et saccharose.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | PHARMACEUTICAL COMPOSITIONS COMPRISING ANTI-191P4D12 ANTIBODY DRUG CONJUGATES AND METHODS OF USE THEREOF |
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