NOVEL TRIPLE-HELICAL POLYPEPTIDES LACKING BINDING AFFINITY FOR THE FC DOMAIN OF IMMUNOGLOBULIN AND USES THEREOF
The present invention relates to the field of protein engineering and purification and relates in particular to novel polypeptides having a triple-helical structure and lacking binding affinity for the Fc domain of immunoglobulin. The invention further relates to uses of the novel non-Fc binding pol...
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| creator | ZWARG, Madlen FIEDLER, Erik HAUPTS, Ulrich |
| description | The present invention relates to the field of protein engineering and purification and relates in particular to novel polypeptides having a triple-helical structure and lacking binding affinity for the Fc domain of immunoglobulin. The invention further relates to uses of the novel non-Fc binding polypeptides in technical applications such as affinity chromatography, as well as in therapy and diagnostics. In addition, the present invention relates to a method of reducing the binding affinity of a polypeptide having a triple-helical structure for the Fc domain of immunoglobulin.
La présente invention se rapporte au domaine de l'ingénierie et de la purification de protéines et concerne en particulier de nouveaux polypeptides ayant une structure à triple hélice et dépourvus d'affinité de liaison pour le domaine Fc de l'immunoglobuline. L'invention concerne en outre des utilisations des nouveaux polypeptides de liaison non Fc dans des applications techniques telles que la chromatographie d'affinité, ainsi qu'en thérapie et en diagnostic. De plus, la présente invention concerne un procédé de réduction de l'affinité de liaison d'un polypeptide ayant une structure à triple hélice pour le domaine Fc de l'immunoglobuline. |
| format | Patent |
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La présente invention se rapporte au domaine de l'ingénierie et de la purification de protéines et concerne en particulier de nouveaux polypeptides ayant une structure à triple hélice et dépourvus d'affinité de liaison pour le domaine Fc de l'immunoglobuline. L'invention concerne en outre des utilisations des nouveaux polypeptides de liaison non Fc dans des applications techniques telles que la chromatographie d'affinité, ainsi qu'en thérapie et en diagnostic. De plus, la présente invention concerne un procédé de réduction de l'affinité de liaison d'un polypeptide ayant une structure à triple hélice pour le domaine Fc de l'immunoglobuline.</description><language>eng ; fre</language><subject>CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200522&DB=EPODOC&CC=WO&NR=2020099442A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25555,76308</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200522&DB=EPODOC&CC=WO&NR=2020099442A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZWARG, Madlen</creatorcontrib><creatorcontrib>FIEDLER, Erik</creatorcontrib><creatorcontrib>HAUPTS, Ulrich</creatorcontrib><title>NOVEL TRIPLE-HELICAL POLYPEPTIDES LACKING BINDING AFFINITY FOR THE FC DOMAIN OF IMMUNOGLOBULIN AND USES THEREOF</title><description>The present invention relates to the field of protein engineering and purification and relates in particular to novel polypeptides having a triple-helical structure and lacking binding affinity for the Fc domain of immunoglobulin. The invention further relates to uses of the novel non-Fc binding polypeptides in technical applications such as affinity chromatography, as well as in therapy and diagnostics. In addition, the present invention relates to a method of reducing the binding affinity of a polypeptide having a triple-helical structure for the Fc domain of immunoglobulin.
La présente invention se rapporte au domaine de l'ingénierie et de la purification de protéines et concerne en particulier de nouveaux polypeptides ayant une structure à triple hélice et dépourvus d'affinité de liaison pour le domaine Fc de l'immunoglobuline. L'invention concerne en outre des utilisations des nouveaux polypeptides de liaison non Fc dans des applications techniques telles que la chromatographie d'affinité, ainsi qu'en thérapie et en diagnostic. De plus, la présente invention concerne un procédé de réduction de l'affinité de liaison d'un polypeptide ayant une structure à triple hélice pour le domaine Fc de l'immunoglobuline.</description><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjMEKgkAUAL10iOofHnQWzLx4XHff6qN136Jr4UkktlOkYP9PBn1Ap4FhmG00Wb6iAd-QMxhXaEgKA45N79B5UtiCEfJCtoSCrPpSaE2WfA-aG_AVgpaguBZkgTVQXXeWS8NFZ1YjrIKuXS9r2CDrfbR5jM8lHH7cRUeNXlZxmKchLPN4D6_wHm6cJmmS5HmWpeJ0_q_6AHPpOFg</recordid><startdate>20200522</startdate><enddate>20200522</enddate><creator>ZWARG, Madlen</creator><creator>FIEDLER, Erik</creator><creator>HAUPTS, Ulrich</creator><scope>EVB</scope></search><sort><creationdate>20200522</creationdate><title>NOVEL TRIPLE-HELICAL POLYPEPTIDES LACKING BINDING AFFINITY FOR THE FC DOMAIN OF IMMUNOGLOBULIN AND USES THEREOF</title><author>ZWARG, Madlen ; FIEDLER, Erik ; HAUPTS, Ulrich</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2020099442A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2020</creationdate><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><toplevel>online_resources</toplevel><creatorcontrib>ZWARG, Madlen</creatorcontrib><creatorcontrib>FIEDLER, Erik</creatorcontrib><creatorcontrib>HAUPTS, Ulrich</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZWARG, Madlen</au><au>FIEDLER, Erik</au><au>HAUPTS, Ulrich</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NOVEL TRIPLE-HELICAL POLYPEPTIDES LACKING BINDING AFFINITY FOR THE FC DOMAIN OF IMMUNOGLOBULIN AND USES THEREOF</title><date>2020-05-22</date><risdate>2020</risdate><abstract>The present invention relates to the field of protein engineering and purification and relates in particular to novel polypeptides having a triple-helical structure and lacking binding affinity for the Fc domain of immunoglobulin. The invention further relates to uses of the novel non-Fc binding polypeptides in technical applications such as affinity chromatography, as well as in therapy and diagnostics. In addition, the present invention relates to a method of reducing the binding affinity of a polypeptide having a triple-helical structure for the Fc domain of immunoglobulin.
La présente invention se rapporte au domaine de l'ingénierie et de la purification de protéines et concerne en particulier de nouveaux polypeptides ayant une structure à triple hélice et dépourvus d'affinité de liaison pour le domaine Fc de l'immunoglobuline. L'invention concerne en outre des utilisations des nouveaux polypeptides de liaison non Fc dans des applications techniques telles que la chromatographie d'affinité, ainsi qu'en thérapie et en diagnostic. De plus, la présente invention concerne un procédé de réduction de l'affinité de liaison d'un polypeptide ayant une structure à triple hélice pour le domaine Fc de l'immunoglobuline.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY METALLURGY ORGANIC CHEMISTRY PEPTIDES |
| title | NOVEL TRIPLE-HELICAL POLYPEPTIDES LACKING BINDING AFFINITY FOR THE FC DOMAIN OF IMMUNOGLOBULIN AND USES THEREOF |
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