NOVEL AMORPHOUS ACTIVE PHARMACEUTICAL INGREDIENTS COMPRISING SUBSTANTIALLY AMORPHOUS MESOPOROUS MAGNESIUM CARBONATE

The present invention is directed to a solid and substantially amorphous active pharmaceutical ingredient, to an oral pharmaceutical formulation comprising said substantially amorphous active pharmaceutical ingredient, as well as to a method for the manufacture of the same. The invention is also dir...

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Hauptverfasser: LINDMARK, Tuulikki, ARVÉN, Ottilia, ÅSBERG, Peter, FRYKSTRAND ÅNGSTRÖM, Sara
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creator LINDMARK, Tuulikki
ARVÉN, Ottilia
ÅSBERG, Peter
FRYKSTRAND ÅNGSTRÖM, Sara
description The present invention is directed to a solid and substantially amorphous active pharmaceutical ingredient, to an oral pharmaceutical formulation comprising said substantially amorphous active pharmaceutical ingredient, as well as to a method for the manufacture of the same. The invention is also directed to a particulate anhydrous and substantially amorphous mesoporous magnesium carbonate(MMC), to a method for the manufacture thereof, and the use of said particulate anhydrous and substantially amorphous mesoporous magnesium carbonate (MMC)to stabilize an active pharmaceutical ingredient (API). La présente invention concerne un principe actif pharmaceutique solide et sensiblement amorphe, une formulation pharmaceutique pour la voie orale comprenant ledit principe actif pharmaceutique sensiblement amorphe, ainsi qu'un procédé de fabrication de celui-ci. L'invention concerne également un carbonate de magnésium mésoporeux (MMC, pour "mesoporous magnesium carbonate") particulaire et sensiblement amorphe, un procédé de fabrication de celui-ci, et l'utilisation dudit carbonate de magnésium mésoporeux (MMC) particulaire et sensiblement amorphe pour stabiliser un principe actif pharmaceutique (API, pour "active pharmaceutical ingredient").
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subjects CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM,CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THERARE-EARTH METALS
HUMAN NECESSITIES
HYGIENE
INORGANIC CHEMISTRY
MEDICAL OR VETERINARY SCIENCE
METALLURGY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
THEIR RELEVANT APPARATUS
TRANSPORTING
title NOVEL AMORPHOUS ACTIVE PHARMACEUTICAL INGREDIENTS COMPRISING SUBSTANTIALLY AMORPHOUS MESOPOROUS MAGNESIUM CARBONATE
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