LIPOXIN A4 ANALOGS AND USES THEREOF
The invention relates to (S)-6-((1 R,2E,4E,8E,10S)-11 -(4-fluorophenoxy)-1,10-dihydroxyundeca- 2,4,8-trien-6-yn-1-yl)-1,4-dioxan-2-one (compound (1)), which is a lactone-containing analog of lipoxin A4 (LXA4). In particular, the invention features pharmaceutical compositions including compound (1) a...
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| creator | LEIGH, Clifton MOSHOS, Kristos CHIANG, Nan SERHAN, Charles JURKAUSKAS, Valdas JENNEQUIN, Thomas TEPPER, Mark CRANE, Sheldon ZHANG, Yuhua |
| description | The invention relates to (S)-6-((1 R,2E,4E,8E,10S)-11 -(4-fluorophenoxy)-1,10-dihydroxyundeca- 2,4,8-trien-6-yn-1-yl)-1,4-dioxan-2-one (compound (1)), which is a lactone-containing analog of lipoxin A4 (LXA4). In particular, the invention features pharmaceutical compositions including compound (1) and the use of compound (1) for the treatment of a disorder (e.g., a fibrotic disorder or an inflammatory disorder, such as an autoimmune disorder) in a subject in need thereof.
L'invention concerne la (S)-6-((1R,2E,4E,8E,10S)-11-(4-fluorophénoxy)-1,10-dihydroxyundéca-2,4,8-trién-6-yn-1-yl)-1,4-dioxan-2-one (composé (1)), qui est un analogue de la lipoxine A4 contenant une lactone (LXA4). En particulier, l'invention concerne des compositions pharmaceutiques comprenant le composé (1) et l'utilisation du composé (1) pour le traitement d'un trouble (par exemple, un trouble fibrotique ou un trouble inflammatoire, tel qu'un trouble auto-immun) chez un sujet qui en a besoin. |
| format | Patent |
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L'invention concerne la (S)-6-((1R,2E,4E,8E,10S)-11-(4-fluorophénoxy)-1,10-dihydroxyundéca-2,4,8-trién-6-yn-1-yl)-1,4-dioxan-2-one (composé (1)), qui est un analogue de la lipoxine A4 contenant une lactone (LXA4). En particulier, l'invention concerne des compositions pharmaceutiques comprenant le composé (1) et l'utilisation du composé (1) pour le traitement d'un trouble (par exemple, un trouble fibrotique ou un trouble inflammatoire, tel qu'un trouble auto-immun) chez un sujet qui en a besoin.</description><language>eng ; fre</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200430&DB=EPODOC&CC=WO&NR=2020086704A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200430&DB=EPODOC&CC=WO&NR=2020086704A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LEIGH, Clifton</creatorcontrib><creatorcontrib>MOSHOS, Kristos</creatorcontrib><creatorcontrib>CHIANG, Nan</creatorcontrib><creatorcontrib>SERHAN, Charles</creatorcontrib><creatorcontrib>JURKAUSKAS, Valdas</creatorcontrib><creatorcontrib>JENNEQUIN, Thomas</creatorcontrib><creatorcontrib>TEPPER, Mark</creatorcontrib><creatorcontrib>CRANE, Sheldon</creatorcontrib><creatorcontrib>ZHANG, Yuhua</creatorcontrib><title>LIPOXIN A4 ANALOGS AND USES THEREOF</title><description>The invention relates to (S)-6-((1 R,2E,4E,8E,10S)-11 -(4-fluorophenoxy)-1,10-dihydroxyundeca- 2,4,8-trien-6-yn-1-yl)-1,4-dioxan-2-one (compound (1)), which is a lactone-containing analog of lipoxin A4 (LXA4). In particular, the invention features pharmaceutical compositions including compound (1) and the use of compound (1) for the treatment of a disorder (e.g., a fibrotic disorder or an inflammatory disorder, such as an autoimmune disorder) in a subject in need thereof.
L'invention concerne la (S)-6-((1R,2E,4E,8E,10S)-11-(4-fluorophénoxy)-1,10-dihydroxyundéca-2,4,8-trién-6-yn-1-yl)-1,4-dioxan-2-one (composé (1)), qui est un analogue de la lipoxine A4 contenant une lactone (LXA4). En particulier, l'invention concerne des compositions pharmaceutiques comprenant le composé (1) et l'utilisation du composé (1) pour le traitement d'un trouble (par exemple, un trouble fibrotique ou un trouble inflammatoire, tel qu'un trouble auto-immun) chez un sujet qui en a besoin.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFD28Qzwj_D0U3A0UXD0c_Txdw8G0i4KocGuwQohHq5Brv5uPAysaYk5xam8UJqbQdnNNcTZQze1ID8-tbggMTk1L7UkPtzfyMDIwMDCzNzAxNHQmDhVAMLaI1E</recordid><startdate>20200430</startdate><enddate>20200430</enddate><creator>LEIGH, Clifton</creator><creator>MOSHOS, Kristos</creator><creator>CHIANG, Nan</creator><creator>SERHAN, Charles</creator><creator>JURKAUSKAS, Valdas</creator><creator>JENNEQUIN, Thomas</creator><creator>TEPPER, Mark</creator><creator>CRANE, Sheldon</creator><creator>ZHANG, Yuhua</creator><scope>EVB</scope></search><sort><creationdate>20200430</creationdate><title>LIPOXIN A4 ANALOGS AND USES THEREOF</title><author>LEIGH, Clifton ; MOSHOS, Kristos ; CHIANG, Nan ; SERHAN, Charles ; JURKAUSKAS, Valdas ; JENNEQUIN, Thomas ; TEPPER, Mark ; CRANE, Sheldon ; ZHANG, Yuhua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2020086704A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2020</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>LEIGH, Clifton</creatorcontrib><creatorcontrib>MOSHOS, Kristos</creatorcontrib><creatorcontrib>CHIANG, Nan</creatorcontrib><creatorcontrib>SERHAN, Charles</creatorcontrib><creatorcontrib>JURKAUSKAS, Valdas</creatorcontrib><creatorcontrib>JENNEQUIN, Thomas</creatorcontrib><creatorcontrib>TEPPER, Mark</creatorcontrib><creatorcontrib>CRANE, Sheldon</creatorcontrib><creatorcontrib>ZHANG, Yuhua</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LEIGH, Clifton</au><au>MOSHOS, Kristos</au><au>CHIANG, Nan</au><au>SERHAN, Charles</au><au>JURKAUSKAS, Valdas</au><au>JENNEQUIN, Thomas</au><au>TEPPER, Mark</au><au>CRANE, Sheldon</au><au>ZHANG, Yuhua</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>LIPOXIN A4 ANALOGS AND USES THEREOF</title><date>2020-04-30</date><risdate>2020</risdate><abstract>The invention relates to (S)-6-((1 R,2E,4E,8E,10S)-11 -(4-fluorophenoxy)-1,10-dihydroxyundeca- 2,4,8-trien-6-yn-1-yl)-1,4-dioxan-2-one (compound (1)), which is a lactone-containing analog of lipoxin A4 (LXA4). In particular, the invention features pharmaceutical compositions including compound (1) and the use of compound (1) for the treatment of a disorder (e.g., a fibrotic disorder or an inflammatory disorder, such as an autoimmune disorder) in a subject in need thereof.
L'invention concerne la (S)-6-((1R,2E,4E,8E,10S)-11-(4-fluorophénoxy)-1,10-dihydroxyundéca-2,4,8-trién-6-yn-1-yl)-1,4-dioxan-2-one (composé (1)), qui est un analogue de la lipoxine A4 contenant une lactone (LXA4). En particulier, l'invention concerne des compositions pharmaceutiques comprenant le composé (1) et l'utilisation du composé (1) pour le traitement d'un trouble (par exemple, un trouble fibrotique ou un trouble inflammatoire, tel qu'un trouble auto-immun) chez un sujet qui en a besoin.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | LIPOXIN A4 ANALOGS AND USES THEREOF |
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