LIPOXIN A4 ANALOGS AND USES THEREOF

The invention relates to (S)-6-((1 R,2E,4E,8E,10S)-11 -(4-fluorophenoxy)-1,10-dihydroxyundeca- 2,4,8-trien-6-yn-1-yl)-1,4-dioxan-2-one (compound (1)), which is a lactone-containing analog of lipoxin A4 (LXA4). In particular, the invention features pharmaceutical compositions including compound (1) a...

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Bibliographische Detailangaben
Hauptverfasser:	LEIGH, Clifton, MOSHOS, Kristos, CHIANG, Nan, SERHAN, Charles, JURKAUSKAS, Valdas, JENNEQUIN, Thomas, TEPPER, Mark, CRANE, Sheldon, ZHANG, Yuhua
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The invention relates to (S)-6-((1 R,2E,4E,8E,10S)-11 -(4-fluorophenoxy)-1,10-dihydroxyundeca- 2,4,8-trien-6-yn-1-yl)-1,4-dioxan-2-one (compound (1)), which is a lactone-containing analog of lipoxin A4 (LXA4). In particular, the invention features pharmaceutical compositions including compound (1) and the use of compound (1) for the treatment of a disorder (e.g., a fibrotic disorder or an inflammatory disorder, such as an autoimmune disorder) in a subject in need thereof. L'invention concerne la (S)-6-((1R,2E,4E,8E,10S)-11-(4-fluorophénoxy)-1,10-dihydroxyundéca-2,4,8-trién-6-yn-1-yl)-1,4-dioxan-2-one (composé (1)), qui est un analogue de la lipoxine A4 contenant une lactone (LXA4). En particulier, l'invention concerne des compositions pharmaceutiques comprenant le composé (1) et l'utilisation du composé (1) pour le traitement d'un trouble (par exemple, un trouble fibrotique ou un trouble inflammatoire, tel qu'un trouble auto-immun) chez un sujet qui en a besoin.