INHIBITORS OF PICK1 AND USES THEREOF
The present invention relates to peptides and peptide analogues with high affinity for the PDZ domains of PICK1. The peptide or peptide analogue interacts with PICK1, blocking the native protein-protein interactions between PICK1 and its natural ligands. The invention furthermore relates to the ther...
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| creator | GETHER, Ulrik STRØMGAARD, Kristian BACH, Anders CHRISTENSEN, Nikolaj MADSEN, Kenneth |
| description | The present invention relates to peptides and peptide analogues with high affinity for the PDZ domains of PICK1. The peptide or peptide analogue interacts with PICK1, blocking the native protein-protein interactions between PICK1 and its natural ligands. The invention furthermore relates to the therapeutic use of these peptides and peptide analogues in prevention and/or treatment of diseases and disorders associated with maladaptive plasticity, drug addiction and neuropathic pain.
La présente invention concerne des peptides et des analogues peptidiques ayant une affinité élevée pour les domaines PDZ de PICK1. Le peptide ou l'analogue peptidique interagit avec PICK1, bloquant les interactions protéine-protéine natives entre PICK1 et ses ligands naturels. L'invention concerne en outre l'utilisation thérapeutique de ces peptides et analogues peptidiques dans la prévention et/ou le traitement de maladies et de troubles associés à une plasticité maladaptative, une toxicomanie et une douleur neuropathique. |
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La présente invention concerne des peptides et des analogues peptidiques ayant une affinité élevée pour les domaines PDZ de PICK1. Le peptide ou l'analogue peptidique interagit avec PICK1, bloquant les interactions protéine-protéine natives entre PICK1 et ses ligands naturels. L'invention concerne en outre l'utilisation thérapeutique de ces peptides et analogues peptidiques dans la prévention et/ou le traitement de maladies et de troubles associés à une plasticité maladaptative, une toxicomanie et une douleur neuropathique.</description><language>eng ; fre</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200430&DB=EPODOC&CC=WO&NR=2020083905A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200430&DB=EPODOC&CC=WO&NR=2020083905A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GETHER, Ulrik</creatorcontrib><creatorcontrib>STRØMGAARD, Kristian</creatorcontrib><creatorcontrib>BACH, Anders</creatorcontrib><creatorcontrib>CHRISTENSEN, Nikolaj</creatorcontrib><creatorcontrib>MADSEN, Kenneth</creatorcontrib><title>INHIBITORS OF PICK1 AND USES THEREOF</title><description>The present invention relates to peptides and peptide analogues with high affinity for the PDZ domains of PICK1. The peptide or peptide analogue interacts with PICK1, blocking the native protein-protein interactions between PICK1 and its natural ligands. The invention furthermore relates to the therapeutic use of these peptides and peptide analogues in prevention and/or treatment of diseases and disorders associated with maladaptive plasticity, drug addiction and neuropathic pain.
La présente invention concerne des peptides et des analogues peptidiques ayant une affinité élevée pour les domaines PDZ de PICK1. Le peptide ou l'analogue peptidique interagit avec PICK1, bloquant les interactions protéine-protéine natives entre PICK1 et ses ligands naturels. L'invention concerne en outre l'utilisation thérapeutique de ces peptides et analogues peptidiques dans la prévention et/ou le traitement de maladies et de troubles associés à une plasticité maladaptative, une toxicomanie et une douleur neuropathique.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFDx9PPwdPIM8Q8KVvB3UwjwdPY2VHD0c1EIDXYNVgjxcA1y9XfjYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXx4f5GBkYGBhbGlgamjobGxKkCAOovI50</recordid><startdate>20200430</startdate><enddate>20200430</enddate><creator>GETHER, Ulrik</creator><creator>STRØMGAARD, Kristian</creator><creator>BACH, Anders</creator><creator>CHRISTENSEN, Nikolaj</creator><creator>MADSEN, Kenneth</creator><scope>EVB</scope></search><sort><creationdate>20200430</creationdate><title>INHIBITORS OF PICK1 AND USES THEREOF</title><author>GETHER, Ulrik ; STRØMGAARD, Kristian ; BACH, Anders ; CHRISTENSEN, Nikolaj ; MADSEN, Kenneth</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2020083905A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2020</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>GETHER, Ulrik</creatorcontrib><creatorcontrib>STRØMGAARD, Kristian</creatorcontrib><creatorcontrib>BACH, Anders</creatorcontrib><creatorcontrib>CHRISTENSEN, Nikolaj</creatorcontrib><creatorcontrib>MADSEN, Kenneth</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GETHER, Ulrik</au><au>STRØMGAARD, Kristian</au><au>BACH, Anders</au><au>CHRISTENSEN, Nikolaj</au><au>MADSEN, Kenneth</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>INHIBITORS OF PICK1 AND USES THEREOF</title><date>2020-04-30</date><risdate>2020</risdate><abstract>The present invention relates to peptides and peptide analogues with high affinity for the PDZ domains of PICK1. The peptide or peptide analogue interacts with PICK1, blocking the native protein-protein interactions between PICK1 and its natural ligands. The invention furthermore relates to the therapeutic use of these peptides and peptide analogues in prevention and/or treatment of diseases and disorders associated with maladaptive plasticity, drug addiction and neuropathic pain.
La présente invention concerne des peptides et des analogues peptidiques ayant une affinité élevée pour les domaines PDZ de PICK1. Le peptide ou l'analogue peptidique interagit avec PICK1, bloquant les interactions protéine-protéine natives entre PICK1 et ses ligands naturels. L'invention concerne en outre l'utilisation thérapeutique de ces peptides et analogues peptidiques dans la prévention et/ou le traitement de maladies et de troubles associés à une plasticité maladaptative, une toxicomanie et une douleur neuropathique.</abstract><oa>free_for_read</oa></addata></record> |
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| title | INHIBITORS OF PICK1 AND USES THEREOF |
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