CRYSTALLINE POLYMORPHS OF BRUTON'S TYROSINE KINASE INHIBITORS

Provided are crystalline forms of (R)-1-(tert-butyl)-N-(8-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-2-(oxetan-3-yl)-2,3,4,5-tetrahydro-1H-benzo[c]azepin-5-yl)-1H-1,2,3-triazole-4-carboxamide, pharmaceutical compositions, methods of use and methods of making thereof. L'invention concer...

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Bibliographische Detailangaben
Hauptverfasser:	PETERSON, Anton, VASUDEVAN, Kalyan, LI, Chaomin, LIN, Yiqing, PATIENCE, Daniel, ZHENG, Fengmei
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided are crystalline forms of (R)-1-(tert-butyl)-N-(8-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-2-(oxetan-3-yl)-2,3,4,5-tetrahydro-1H-benzo[c]azepin-5-yl)-1H-1,2,3-triazole-4-carboxamide, pharmaceutical compositions, methods of use and methods of making thereof. L'invention concerne des formes cristallines de (R)-1-(tert-butyl)-N-(8-(2-((1-méthyl-1H-pyrazol-4-yl) amino) pyrimidin-4-yl)-2-(oxétan-3-yl))-2,3,4,5-tétrahydro-1H-benzo[c]azépin-5-yl)-1H-1,2,3-triazole-4-carboxamide, des compositions pharmaceutiques, des procédés d'utilisation et des procédés de production de ceux-ci.