LACTOCOCCUS LACTIS EXPRESSION SYSTEM FOR DELIVERING PROTEINS EFFICACIOUS FOR THE TREATMENT OF EPITHELIAL BARRIER FUNCTION DISORDERS
The disclosure relates to live biotherapeutic products, probiotics, and therapeutic compositions comprising said probiotics having therapeutic proteins, and methods of using them to treat various human diseases. In particular aspects, the disclosure provides such compositions comprising strains of t...
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| creator | WILLCOXON, Michi Izumi HAN, Andrew Wonhee KEILBERG, Daniela GOODYEAR, Andrew W |
| description | The disclosure relates to live biotherapeutic products, probiotics, and therapeutic compositions comprising said probiotics having therapeutic proteins, and methods of using them to treat various human diseases. In particular aspects, the disclosure provides such compositions comprising strains of the lactococcus lactis bacterium within which said therapeutic proteins are present. The disclosed pharmaceutical compositions are useful for treating gastrointestinal inflammatory diseases and gastrointestinal conditions associated with decreased epithelial cell barrier function or integrity, especially, for treating or preventing various types of mucositis.
L'invention concerne des produits biothérapeutiques vivants, des probiotiques, des compositions thérapeutiques comprenant lesdits probiotiques contenant des protéines thérapeutiques, et leurs procédés d'utilisation pour traiter diverses maladies humaines. Dans des aspects particuliers, l'invention concerne de telles compositions comprenant des souches de la bactérie lactococcus lactis dans lesquelles lesdites protéines thérapeutiques sont présentes. Les compositions pharmaceutiques décrites sont utiles pour traiter des maladies inflammatoires gastro-intestinales et des affections gastro-intestinales associées à une fonction ou une intégrité de barrière cellulaire épithéliale réduite, en particulier pour traiter ou prévenir divers types de mucosite. |
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L'invention concerne des produits biothérapeutiques vivants, des probiotiques, des compositions thérapeutiques comprenant lesdits probiotiques contenant des protéines thérapeutiques, et leurs procédés d'utilisation pour traiter diverses maladies humaines. Dans des aspects particuliers, l'invention concerne de telles compositions comprenant des souches de la bactérie lactococcus lactis dans lesquelles lesdites protéines thérapeutiques sont présentes. Les compositions pharmaceutiques décrites sont utiles pour traiter des maladies inflammatoires gastro-intestinales et des affections gastro-intestinales associées à une fonction ou une intégrité de barrière cellulaire épithéliale réduite, en particulier pour traiter ou prévenir divers types de mucosite.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200416&DB=EPODOC&CC=WO&NR=2020077010A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200416&DB=EPODOC&CC=WO&NR=2020077010A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WILLCOXON, Michi Izumi</creatorcontrib><creatorcontrib>HAN, Andrew Wonhee</creatorcontrib><creatorcontrib>KEILBERG, Daniela</creatorcontrib><creatorcontrib>GOODYEAR, Andrew W</creatorcontrib><title>LACTOCOCCUS LACTIS EXPRESSION SYSTEM FOR DELIVERING PROTEINS EFFICACIOUS FOR THE TREATMENT OF EPITHELIAL BARRIER FUNCTION DISORDERS</title><description>The disclosure relates to live biotherapeutic products, probiotics, and therapeutic compositions comprising said probiotics having therapeutic proteins, and methods of using them to treat various human diseases. In particular aspects, the disclosure provides such compositions comprising strains of the lactococcus lactis bacterium within which said therapeutic proteins are present. The disclosed pharmaceutical compositions are useful for treating gastrointestinal inflammatory diseases and gastrointestinal conditions associated with decreased epithelial cell barrier function or integrity, especially, for treating or preventing various types of mucositis.
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L'invention concerne des produits biothérapeutiques vivants, des probiotiques, des compositions thérapeutiques comprenant lesdits probiotiques contenant des protéines thérapeutiques, et leurs procédés d'utilisation pour traiter diverses maladies humaines. Dans des aspects particuliers, l'invention concerne de telles compositions comprenant des souches de la bactérie lactococcus lactis dans lesquelles lesdites protéines thérapeutiques sont présentes. Les compositions pharmaceutiques décrites sont utiles pour traiter des maladies inflammatoires gastro-intestinales et des affections gastro-intestinales associées à une fonction ou une intégrité de barrière cellulaire épithéliale réduite, en particulier pour traiter ou prévenir divers types de mucosite.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | LACTOCOCCUS LACTIS EXPRESSION SYSTEM FOR DELIVERING PROTEINS EFFICACIOUS FOR THE TREATMENT OF EPITHELIAL BARRIER FUNCTION DISORDERS |
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