ACYLHYDRAZONES FOR THE TREATMENT OF NEUROLOGICAL DISEASES
The invention relates to a group of compounds with a structural nucleus of acylhydrazone, which are capable of modulating the interaction between the proteins NCS-1 and Ric8a involved in the process of regulating the number of synapses and the probability of release of neurotransmitters. These compo...
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| creator | PÉREZ FERNÁNDEZ, Ruth CANAL MARTÍN, Andrea MANSILLA APARICIO, Alicia SANCHEZ BARRENA, María José |
| description | The invention relates to a group of compounds with a structural nucleus of acylhydrazone, which are capable of modulating the interaction between the proteins NCS-1 and Ric8a involved in the process of regulating the number of synapses and the probability of release of neurotransmitters. These compounds can therefore be used for the treatment of neurological diseases in which the number of synapses is affected, such as Alzheimer's disease, Huntington's disease or Parkinson's disease.
La presente invención se refiere a un grupo de compuestos con un núcleo estructural de acilhidrazona que presentan capacidad moduladora de la interacción entre las proteínas NCS-1 y Ric8a, implicadas en el proceso de regulación del número de sinapsis y la probabilidad de liberación de neurotransmisores.Estos compuestos, por tanto, son útiles para el tratamiento de enfermedades neurológicas en las que está afectado el número de sinapsis, tales como enfermedad de Alzheimer, enfermedad de Huntington o enfermedad de Parkinson.
La présente invention concerne un groupe de composés ayant un noyau structural en acylhydrazone qui présentent une capactié de modulation de l'interaction entre les protéines NCS-1 et Ric8a, impliquées dans le processus de régulation du nombre de synapses et la probabilité de libération de neurotransmetteurs. Ces composés, par conséquent, sont utiles pour le traitement de maladies neurologiques dans lesquelles le nombre de synapses est affecté, comme la maladie d'Alzheimer, la maladie de Huntington ou la maladie de Parkinson. |
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La presente invención se refiere a un grupo de compuestos con un núcleo estructural de acilhidrazona que presentan capacidad moduladora de la interacción entre las proteínas NCS-1 y Ric8a, implicadas en el proceso de regulación del número de sinapsis y la probabilidad de liberación de neurotransmisores.Estos compuestos, por tanto, son útiles para el tratamiento de enfermedades neurológicas en las que está afectado el número de sinapsis, tales como enfermedad de Alzheimer, enfermedad de Huntington o enfermedad de Parkinson.
La présente invention concerne un groupe de composés ayant un noyau structural en acylhydrazone qui présentent une capactié de modulation de l'interaction entre les protéines NCS-1 et Ric8a, impliquées dans le processus de régulation du nombre de synapses et la probabilité de libération de neurotransmetteurs. Ces composés, par conséquent, sont utiles pour le traitement de maladies neurologiques dans lesquelles le nombre de synapses est affecté, comme la maladie d'Alzheimer, la maladie de Huntington ou la maladie de Parkinson.</description><language>eng ; fre ; spa</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200402&DB=EPODOC&CC=WO&NR=2020065119A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200402&DB=EPODOC&CC=WO&NR=2020065119A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PÉREZ FERNÁNDEZ, Ruth</creatorcontrib><creatorcontrib>CANAL MARTÍN, Andrea</creatorcontrib><creatorcontrib>MANSILLA APARICIO, Alicia</creatorcontrib><creatorcontrib>SANCHEZ BARRENA, María José</creatorcontrib><title>ACYLHYDRAZONES FOR THE TREATMENT OF NEUROLOGICAL DISEASES</title><description>The invention relates to a group of compounds with a structural nucleus of acylhydrazone, which are capable of modulating the interaction between the proteins NCS-1 and Ric8a involved in the process of regulating the number of synapses and the probability of release of neurotransmitters. These compounds can therefore be used for the treatment of neurological diseases in which the number of synapses is affected, such as Alzheimer's disease, Huntington's disease or Parkinson's disease.
La presente invención se refiere a un grupo de compuestos con un núcleo estructural de acilhidrazona que presentan capacidad moduladora de la interacción entre las proteínas NCS-1 y Ric8a, implicadas en el proceso de regulación del número de sinapsis y la probabilidad de liberación de neurotransmisores.Estos compuestos, por tanto, son útiles para el tratamiento de enfermedades neurológicas en las que está afectado el número de sinapsis, tales como enfermedad de Alzheimer, enfermedad de Huntington o enfermedad de Parkinson.
La présente invention concerne un groupe de composés ayant un noyau structural en acylhydrazone qui présentent une capactié de modulation de l'interaction entre les protéines NCS-1 et Ric8a, impliquées dans le processus de régulation du nombre de synapses et la probabilité de libération de neurotransmetteurs. Ces composés, par conséquent, sont utiles pour le traitement de maladies neurologiques dans lesquelles le nombre de synapses est affecté, comme la maladie d'Alzheimer, la maladie de Huntington ou la maladie de Parkinson.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLB0dI708Yh0CXKM8vdzDVZw8w9SCPFwVQgJcnUM8XX1C1Hwd1Pwcw0N8vfxd_d0dvRRcPEMdnUMdg3mYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXx4f5GBkYGBmamhoaWjobGxKkCAE0BKdo</recordid><startdate>20200402</startdate><enddate>20200402</enddate><creator>PÉREZ FERNÁNDEZ, Ruth</creator><creator>CANAL MARTÍN, Andrea</creator><creator>MANSILLA APARICIO, Alicia</creator><creator>SANCHEZ BARRENA, María José</creator><scope>EVB</scope></search><sort><creationdate>20200402</creationdate><title>ACYLHYDRAZONES FOR THE TREATMENT OF NEUROLOGICAL DISEASES</title><author>PÉREZ FERNÁNDEZ, Ruth ; CANAL MARTÍN, Andrea ; MANSILLA APARICIO, Alicia ; SANCHEZ BARRENA, María José</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2020065119A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; spa</language><creationdate>2020</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>PÉREZ FERNÁNDEZ, Ruth</creatorcontrib><creatorcontrib>CANAL MARTÍN, Andrea</creatorcontrib><creatorcontrib>MANSILLA APARICIO, Alicia</creatorcontrib><creatorcontrib>SANCHEZ BARRENA, María José</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PÉREZ FERNÁNDEZ, Ruth</au><au>CANAL MARTÍN, Andrea</au><au>MANSILLA APARICIO, Alicia</au><au>SANCHEZ BARRENA, María José</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ACYLHYDRAZONES FOR THE TREATMENT OF NEUROLOGICAL DISEASES</title><date>2020-04-02</date><risdate>2020</risdate><abstract>The invention relates to a group of compounds with a structural nucleus of acylhydrazone, which are capable of modulating the interaction between the proteins NCS-1 and Ric8a involved in the process of regulating the number of synapses and the probability of release of neurotransmitters. These compounds can therefore be used for the treatment of neurological diseases in which the number of synapses is affected, such as Alzheimer's disease, Huntington's disease or Parkinson's disease.
La presente invención se refiere a un grupo de compuestos con un núcleo estructural de acilhidrazona que presentan capacidad moduladora de la interacción entre las proteínas NCS-1 y Ric8a, implicadas en el proceso de regulación del número de sinapsis y la probabilidad de liberación de neurotransmisores.Estos compuestos, por tanto, son útiles para el tratamiento de enfermedades neurológicas en las que está afectado el número de sinapsis, tales como enfermedad de Alzheimer, enfermedad de Huntington o enfermedad de Parkinson.
La présente invention concerne un groupe de composés ayant un noyau structural en acylhydrazone qui présentent une capactié de modulation de l'interaction entre les protéines NCS-1 et Ric8a, impliquées dans le processus de régulation du nombre de synapses et la probabilité de libération de neurotransmetteurs. Ces composés, par conséquent, sont utiles pour le traitement de maladies neurologiques dans lesquelles le nombre de synapses est affecté, comme la maladie d'Alzheimer, la maladie de Huntington ou la maladie de Parkinson.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | ACYLHYDRAZONES FOR THE TREATMENT OF NEUROLOGICAL DISEASES |
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