AN IMPROVED PROCESS FOR THE PREPARATION OF SUGAMMADEX SODIUM AND ITS NOVEL POLYMORPHIC FORM

The present invention provides an improved process for the preparation of Sugammadex sodium of formula (I) having more than 98.5% purity along with less than 1.0% monohydroxy Sugammadex sodium and less than 0.15% any other known or unknown impurities by HPLC. La présente invention concerne un procéd...

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Hauptverfasser: PULLA REDDY, Muddasani, VENKAIAH CHOWDARY, Nannapaneni, SHANKAR REDDY, Budideti, SAIDULU, Baddula, RAJASHEKAR, Kotte, PRABHAKAR, Vanga, NAGA VASANTA SRINIVASU, Vuppalapati, SRINIVASA KRISHNA MURTHY, Konduri, RAJASEKHARA REDDY, Peddi
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creator PULLA REDDY, Muddasani
VENKAIAH CHOWDARY, Nannapaneni
SHANKAR REDDY, Budideti
SAIDULU, Baddula
RAJASHEKAR, Kotte
PRABHAKAR, Vanga
NAGA VASANTA SRINIVASU, Vuppalapati
SRINIVASA KRISHNA MURTHY, Konduri
RAJASEKHARA REDDY, Peddi
description The present invention provides an improved process for the preparation of Sugammadex sodium of formula (I) having more than 98.5% purity along with less than 1.0% monohydroxy Sugammadex sodium and less than 0.15% any other known or unknown impurities by HPLC. La présente invention concerne un procédé amélioré pour la préparation de sugammadex sodique de formule (I) présentant une pureté supérieure à 98,5 % tout en présentant moins de 1,0 % de monohydroxysugammadex sodique et moins de 0,15 % d'autres impuretés connues ou inconnues par HPLC. Formule-I
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La présente invention concerne un procédé amélioré pour la préparation de sugammadex sodique de formule (I) présentant une pureté supérieure à 98,5 % tout en présentant moins de 1,0 % de monohydroxysugammadex sodique et moins de 0,15 % d'autres impuretés connues ou inconnues par HPLC. 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subjects CHEMISTRY
COMPOSITIONS BASED THEREON
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC MACROMOLECULAR COMPOUNDS
POLYSACCHARIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
THEIR PREPARATION OR CHEMICAL WORKING-UP
title AN IMPROVED PROCESS FOR THE PREPARATION OF SUGAMMADEX SODIUM AND ITS NOVEL POLYMORPHIC FORM
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