METHODS FOR ASSESSING INTEGRATED NUCLEIC ACIDS
Provided are methods for assessing nucleic acid sequences integrated into a genome of a genetically engineered cell, such as a genetically engineered cell used in cell therapy. Cells are generally genetically engineered to express a recombinant protein, such as a recombinant receptor, via introducti...
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| creator | BRIGGS, Adrian Wrangham |
| description | Provided are methods for assessing nucleic acid sequences integrated into a genome of a genetically engineered cell, such as a genetically engineered cell used in cell therapy. Cells are generally genetically engineered to express a recombinant protein, such as a recombinant receptor, via introduction of a polynucleotide and integration of certain sequences in the polynucleotide, such as recombinant sequences, into the genome of the cell. In some aspects, the provided methods can be used to distinguish integrated nucleic acids and non-integrated, residual nucleic acids.
L'invention concerne des procédés pour évaluer des séquences d'acides nucléiques intégrées dans un génome d'une cellule génétiquement modifiée, telle qu'une cellule génétiquement modifiée utilisée en thérapie cellulaire. Les cellules sont généralement génétiquement modifiées pour exprimer une protéine recombinante, telle qu'un récepteur recombinant, par introduction d'un polynucléotide et intégration de certaines séquences du polynucléotide, telles que des séquences recombinantes, dans le génome de la cellule. Selon certains aspects, les procédés de l'invention peuvent être utilisés pour distinguer des acides nucléiques intégrés et des acides nucléiques résiduels non intégrés. |
| format | Patent |
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L'invention concerne des procédés pour évaluer des séquences d'acides nucléiques intégrées dans un génome d'une cellule génétiquement modifiée, telle qu'une cellule génétiquement modifiée utilisée en thérapie cellulaire. Les cellules sont généralement génétiquement modifiées pour exprimer une protéine recombinante, telle qu'un récepteur recombinant, par introduction d'un polynucléotide et intégration de certaines séquences du polynucléotide, telles que des séquences recombinantes, dans le génome de la cellule. Selon certains aspects, les procédés de l'invention peuvent être utilisés pour distinguer des acides nucléiques intégrés et des acides nucléiques résiduels non intégrés.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; COMPOSITIONS THEREOF ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; CULTURE MEDIA ; ENZYMOLOGY ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200213&DB=EPODOC&CC=WO&NR=2020033916A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200213&DB=EPODOC&CC=WO&NR=2020033916A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BRIGGS, Adrian Wrangham</creatorcontrib><title>METHODS FOR ASSESSING INTEGRATED NUCLEIC ACIDS</title><description>Provided are methods for assessing nucleic acid sequences integrated into a genome of a genetically engineered cell, such as a genetically engineered cell used in cell therapy. Cells are generally genetically engineered to express a recombinant protein, such as a recombinant receptor, via introduction of a polynucleotide and integration of certain sequences in the polynucleotide, such as recombinant sequences, into the genome of the cell. In some aspects, the provided methods can be used to distinguish integrated nucleic acids and non-integrated, residual nucleic acids.
L'invention concerne des procédés pour évaluer des séquences d'acides nucléiques intégrées dans un génome d'une cellule génétiquement modifiée, telle qu'une cellule génétiquement modifiée utilisée en thérapie cellulaire. Les cellules sont généralement génétiquement modifiées pour exprimer une protéine recombinante, telle qu'un récepteur recombinant, par introduction d'un polynucléotide et intégration de certaines séquences du polynucléotide, telles que des séquences recombinantes, dans le génome de la cellule. Selon certains aspects, les procédés de l'invention peuvent être utilisés pour distinguer des acides nucléiques intégrés et des acides nucléiques résiduels non intégrés.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>COMPOSITIONS THEREOF</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNDzdQ3x8HcJVnDzD1JwDA52DQ729HNX8PQLcXUPcgxxdVHwC3X2cfV0VnB09nQJ5mFgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8eH-RgZGBgbGxpaGZo6GxsSpAgB3KiaS</recordid><startdate>20200213</startdate><enddate>20200213</enddate><creator>BRIGGS, Adrian Wrangham</creator><scope>EVB</scope></search><sort><creationdate>20200213</creationdate><title>METHODS FOR ASSESSING INTEGRATED NUCLEIC ACIDS</title><author>BRIGGS, Adrian Wrangham</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2020033916A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2020</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>COMPOSITIONS THEREOF</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>BRIGGS, Adrian Wrangham</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BRIGGS, Adrian Wrangham</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHODS FOR ASSESSING INTEGRATED NUCLEIC ACIDS</title><date>2020-02-13</date><risdate>2020</risdate><abstract>Provided are methods for assessing nucleic acid sequences integrated into a genome of a genetically engineered cell, such as a genetically engineered cell used in cell therapy. Cells are generally genetically engineered to express a recombinant protein, such as a recombinant receptor, via introduction of a polynucleotide and integration of certain sequences in the polynucleotide, such as recombinant sequences, into the genome of the cell. In some aspects, the provided methods can be used to distinguish integrated nucleic acids and non-integrated, residual nucleic acids.
L'invention concerne des procédés pour évaluer des séquences d'acides nucléiques intégrées dans un génome d'une cellule génétiquement modifiée, telle qu'une cellule génétiquement modifiée utilisée en thérapie cellulaire. Les cellules sont généralement génétiquement modifiées pour exprimer une protéine recombinante, telle qu'un récepteur recombinant, par introduction d'un polynucléotide et intégration de certaines séquences du polynucléotide, telles que des séquences recombinantes, dans le génome de la cellule. Selon certains aspects, les procédés de l'invention peuvent être utilisés pour distinguer des acides nucléiques intégrés et des acides nucléiques résiduels non intégrés.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | METHODS FOR ASSESSING INTEGRATED NUCLEIC ACIDS |
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