COMPOSITIONS AND METHODS FOR INHIBITING INFLAMMATION

As described below, the present invention features compositions and methods for inhibiting inflammation in connection with an acellular template (e.g., an electrospun template). In one embodiment, the template is impregnated with an agent (e.g., N-?-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine ami...

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Bibliographische Detailangaben
Hauptverfasser:	FETZ, Allison E, RADIC, Marko Z, BOWLIN, Gary L
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	As described below, the present invention features compositions and methods for inhibiting inflammation in connection with an acellular template (e.g., an electrospun template). In one embodiment, the template is impregnated with an agent (e.g., N-?-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide (Cl-amidine)) that inhibits a peptidylarginine deaminase (e.g., PAD4). Comme décrit ci-dessous, la présente invention concerne des compositions et des procédés pour inhiber une inflammation en liaison avec un modèle acellulaire (par exemple, un modèle électrofilé). Dans un mode de réalisation, le gabarit est imprégné d'un agent (par exemple, N-?-benzoyl-N5- (2-chloro-1-iminoéthyl))-L-ornithine amide (Cl-amidine)) qui inhibe une peptidylarginine désaminase (par exemple PAD4).