TRISPECIFIC ANTIGEN BINDING PROTEINS
Trispecific antigen-binding proteins including: a first binding domain capable of binding to a cell surface protein of a tumor cell; a second binding domain capable of binding to a cell surface immune checkpoint protein of the tumor cell; and a third binding domain capable of binding to a cell surfa...
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| creator | SCHLEIER, Thomas BORRAS, Leonardo LEISNER, Christian Valdemar Vinge SCHEIFELE, Fabian ESCHER, Dominik RICHLE, Philipp Robert |
| description | Trispecific antigen-binding proteins including: a first binding domain capable of binding to a cell surface protein of a tumor cell; a second binding domain capable of binding to a cell surface immune checkpoint protein of the tumor cell; and a third binding domain capable of binding to a cell surface protein of an immune cell, are provided. Methods of making trispecific antigen-binding proteins are provided.
Des protéines de liaison à un antigène trispécifiques comprennent : un premier domaine de liaison capable de se lier à une protéine de surface cellulaire d'une cellule tumorale; un deuxième domaine de liaison capable de se lier à une protéine de point de contrôle immunitaire de surface cellulaire de la cellule tumorale; et un troisième domaine de liaison capable de se lier à une protéine de surface cellulaire d'une cellule immunitaire. L'invention concerne également des procédés de fabrication de protéines de liaison à un antigène trispécifiques. |
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Des protéines de liaison à un antigène trispécifiques comprennent : un premier domaine de liaison capable de se lier à une protéine de surface cellulaire d'une cellule tumorale; un deuxième domaine de liaison capable de se lier à une protéine de point de contrôle immunitaire de surface cellulaire de la cellule tumorale; et un troisième domaine de liaison capable de se lier à une protéine de surface cellulaire d'une cellule immunitaire. L'invention concerne également des procédés de fabrication de protéines de liaison à un antigène trispécifiques.</description><language>eng ; fre</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190906&DB=EPODOC&CC=WO&NR=2019166650A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190906&DB=EPODOC&CC=WO&NR=2019166650A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SCHLEIER, Thomas</creatorcontrib><creatorcontrib>BORRAS, Leonardo</creatorcontrib><creatorcontrib>LEISNER, Christian Valdemar Vinge</creatorcontrib><creatorcontrib>SCHEIFELE, Fabian</creatorcontrib><creatorcontrib>ESCHER, Dominik</creatorcontrib><creatorcontrib>RICHLE, Philipp Robert</creatorcontrib><title>TRISPECIFIC ANTIGEN BINDING PROTEINS</title><description>Trispecific antigen-binding proteins including: a first binding domain capable of binding to a cell surface protein of a tumor cell; a second binding domain capable of binding to a cell surface immune checkpoint protein of the tumor cell; and a third binding domain capable of binding to a cell surface protein of an immune cell, are provided. Methods of making trispecific antigen-binding proteins are provided.
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Des protéines de liaison à un antigène trispécifiques comprennent : un premier domaine de liaison capable de se lier à une protéine de surface cellulaire d'une cellule tumorale; un deuxième domaine de liaison capable de se lier à une protéine de point de contrôle immunitaire de surface cellulaire de la cellule tumorale; et un troisième domaine de liaison capable de se lier à une protéine de surface cellulaire d'une cellule immunitaire. L'invention concerne également des procédés de fabrication de protéines de liaison à un antigène trispécifiques.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | TRISPECIFIC ANTIGEN BINDING PROTEINS |
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