OXADIAZOLE DERIVATIVES AS RHO-KINASE INHIBITORS
The invention relates to compounds of formula (I) inhibiting Rho Kinase that are oxidazole derivatives, processes for preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many...
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| creator | ACCETTA, Alessandro EDWARDS, Christine SKIDMORE, Elizabeth Anne RANCATI, Fabio |
| description | The invention relates to compounds of formula (I) inhibiting Rho Kinase that are oxidazole derivatives, processes for preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
L'invention concerne des composés de formule (I) inhibant la Rho kinase, qui sont des dérivés d'oxadiazole, des procédés de préparation de ces composés, des compositions pharmaceutiques les contenant et leur utilisation thérapeutique. En particulier, les composés de l'invention peuvent être utiles dans le traitement de nombreux troubles associés à des mécanismes d'enzymes ROCK, tels que les maladies pulmonaires comprenant l'asthme, la bronchopneumopathie chronique obstructive (BPCO), la fibrose pulmonaire idiopathique (FPI) et l'hypertension artérielle pulmonaire (HTAP) |
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L'invention concerne des composés de formule (I) inhibant la Rho kinase, qui sont des dérivés d'oxadiazole, des procédés de préparation de ces composés, des compositions pharmaceutiques les contenant et leur utilisation thérapeutique. En particulier, les composés de l'invention peuvent être utiles dans le traitement de nombreux troubles associés à des mécanismes d'enzymes ROCK, tels que les maladies pulmonaires comprenant l'asthme, la bronchopneumopathie chronique obstructive (BPCO), la fibrose pulmonaire idiopathique (FPI) et l'hypertension artérielle pulmonaire (HTAP)</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190627&DB=EPODOC&CC=WO&NR=2019121233A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190627&DB=EPODOC&CC=WO&NR=2019121233A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ACCETTA, Alessandro</creatorcontrib><creatorcontrib>EDWARDS, Christine</creatorcontrib><creatorcontrib>SKIDMORE, Elizabeth Anne</creatorcontrib><creatorcontrib>RANCATI, Fabio</creatorcontrib><title>OXADIAZOLE DERIVATIVES AS RHO-KINASE INHIBITORS</title><description>The invention relates to compounds of formula (I) inhibiting Rho Kinase that are oxidazole derivatives, processes for preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
L'invention concerne des composés de formule (I) inhibant la Rho kinase, qui sont des dérivés d'oxadiazole, des procédés de préparation de ces composés, des compositions pharmaceutiques les contenant et leur utilisation thérapeutique. En particulier, les composés de l'invention peuvent être utiles dans le traitement de nombreux troubles associés à des mécanismes d'enzymes ROCK, tels que les maladies pulmonaires comprenant l'asthme, la bronchopneumopathie chronique obstructive (BPCO), la fibrose pulmonaire idiopathique (FPI) et l'hypertension artérielle pulmonaire (HTAP)</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZND3j3B08XSM8vdxVXBxDfIMcwzxDHMNVnAMVgjy8Nf19vRzDHZV8PTz8HTyDPEPCuZhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfHh_kYGhpaGRoZGxsaOhsbEqQIAs24nDA</recordid><startdate>20190627</startdate><enddate>20190627</enddate><creator>ACCETTA, Alessandro</creator><creator>EDWARDS, Christine</creator><creator>SKIDMORE, Elizabeth Anne</creator><creator>RANCATI, Fabio</creator><scope>EVB</scope></search><sort><creationdate>20190627</creationdate><title>OXADIAZOLE DERIVATIVES AS RHO-KINASE INHIBITORS</title><author>ACCETTA, Alessandro ; EDWARDS, Christine ; SKIDMORE, Elizabeth Anne ; RANCATI, Fabio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2019121233A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2019</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ACCETTA, Alessandro</creatorcontrib><creatorcontrib>EDWARDS, Christine</creatorcontrib><creatorcontrib>SKIDMORE, Elizabeth Anne</creatorcontrib><creatorcontrib>RANCATI, Fabio</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ACCETTA, Alessandro</au><au>EDWARDS, Christine</au><au>SKIDMORE, Elizabeth Anne</au><au>RANCATI, Fabio</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>OXADIAZOLE DERIVATIVES AS RHO-KINASE INHIBITORS</title><date>2019-06-27</date><risdate>2019</risdate><abstract>The invention relates to compounds of formula (I) inhibiting Rho Kinase that are oxidazole derivatives, processes for preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
L'invention concerne des composés de formule (I) inhibant la Rho kinase, qui sont des dérivés d'oxadiazole, des procédés de préparation de ces composés, des compositions pharmaceutiques les contenant et leur utilisation thérapeutique. En particulier, les composés de l'invention peuvent être utiles dans le traitement de nombreux troubles associés à des mécanismes d'enzymes ROCK, tels que les maladies pulmonaires comprenant l'asthme, la bronchopneumopathie chronique obstructive (BPCO), la fibrose pulmonaire idiopathique (FPI) et l'hypertension artérielle pulmonaire (HTAP)</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | OXADIAZOLE DERIVATIVES AS RHO-KINASE INHIBITORS |
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