A PROCESS FOR THE PREPARATION OF CARIPRAZINE HYDROCHLORIDE
The present invention is directed towards a process for the preparation of Cariprazine (Ia) or a pharmaceutically acceptable salt thereof, wherein, N,N- dimethyl-1H-imidazole-1-carboxamide alkyl halide (VII) is reacted with trans-4- (2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexanamine or a...
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| creator | NEELA, Praveen Kumar SANKINENI, Sampath Kumar BATTHINI, Guruswamy MADDI, Raghavender Reddy BINGI, Hariprasad Reddy MEENAKSHISUNDERAM, Sivakumaran |
| description | The present invention is directed towards a process for the preparation of Cariprazine (Ia) or a pharmaceutically acceptable salt thereof, wherein, N,N- dimethyl-1H-imidazole-1-carboxamide alkyl halide (VII) is reacted with trans-4- (2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexanamine or a salt thereof (IIa) to produce Cariprazine (Ia) or a pharmaceutically acceptable salt thereof. The present invention is also directed towards amorphous form of Cariprazine hydrochloride (I) and solid dispersion of Cariprazine hydrochloride (I), and its preparation thereof.
La présente invention concerne un procédé de préparation de cariprazine (Ia) ou d'un sel pharmaceutiquement acceptable de celle-ci, l'halogénure d'alkyle de N,N-diméthyl-1H-imidazole-1-carboxamide (VII) étant mis à réagir avec du trans-4-(2-(4-(2,3-dichlorophényl)pipérazin-1-yl)éthyl)cyclohexanamine ou un sel de celle-ci (IIa) pour produire la cariprazine (Ia) ou un sel pharmaceutiquement acceptable de celle-ci. La présente invention concerne également une forme amorphe du chlorhydrate de cariprazine (I) et une dispersion solide du chlorhydrate de cariprazine (I), ainsi qu'une préparation correspondante. |
| format | Patent |
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La présente invention concerne un procédé de préparation de cariprazine (Ia) ou d'un sel pharmaceutiquement acceptable de celle-ci, l'halogénure d'alkyle de N,N-diméthyl-1H-imidazole-1-carboxamide (VII) étant mis à réagir avec du trans-4-(2-(4-(2,3-dichlorophényl)pipérazin-1-yl)éthyl)cyclohexanamine ou un sel de celle-ci (IIa) pour produire la cariprazine (Ia) ou un sel pharmaceutiquement acceptable de celle-ci. La présente invention concerne également une forme amorphe du chlorhydrate de cariprazine (I) et une dispersion solide du chlorhydrate de cariprazine (I), ainsi qu'une préparation correspondante.</description><language>eng ; fre</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190606&DB=EPODOC&CC=WO&NR=2019106490A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190606&DB=EPODOC&CC=WO&NR=2019106490A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>NEELA, Praveen Kumar</creatorcontrib><creatorcontrib>SANKINENI, Sampath Kumar</creatorcontrib><creatorcontrib>BATTHINI, Guruswamy</creatorcontrib><creatorcontrib>MADDI, Raghavender Reddy</creatorcontrib><creatorcontrib>BINGI, Hariprasad Reddy</creatorcontrib><creatorcontrib>MEENAKSHISUNDERAM, Sivakumaran</creatorcontrib><title>A PROCESS FOR THE PREPARATION OF CARIPRAZINE HYDROCHLORIDE</title><description>The present invention is directed towards a process for the preparation of Cariprazine (Ia) or a pharmaceutically acceptable salt thereof, wherein, N,N- dimethyl-1H-imidazole-1-carboxamide alkyl halide (VII) is reacted with trans-4- (2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexanamine or a salt thereof (IIa) to produce Cariprazine (Ia) or a pharmaceutically acceptable salt thereof. The present invention is also directed towards amorphous form of Cariprazine hydrochloride (I) and solid dispersion of Cariprazine hydrochloride (I), and its preparation thereof.
La présente invention concerne un procédé de préparation de cariprazine (Ia) ou d'un sel pharmaceutiquement acceptable de celle-ci, l'halogénure d'alkyle de N,N-diméthyl-1H-imidazole-1-carboxamide (VII) étant mis à réagir avec du trans-4-(2-(4-(2,3-dichlorophényl)pipérazin-1-yl)éthyl)cyclohexanamine ou un sel de celle-ci (IIa) pour produire la cariprazine (Ia) ou un sel pharmaceutiquement acceptable de celle-ci. La présente invention concerne également une forme amorphe du chlorhydrate de cariprazine (I) et une dispersion solide du chlorhydrate de cariprazine (I), ainsi qu'une préparation correspondante.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLByVAgI8nd2DQ5WcPMPUgjxcAXyXQMcgxxDPP39FPzdFJwdgzwDghyjPP1cFTwiXYCKPXz8gzxdXHkYWNMSc4pTeaE0N4Oym2uIs4duakF-fGpxQWJyal5qSXy4v5GBoaWhgZmJpYGjoTFxqgBV5Cn7</recordid><startdate>20190606</startdate><enddate>20190606</enddate><creator>NEELA, Praveen Kumar</creator><creator>SANKINENI, Sampath Kumar</creator><creator>BATTHINI, Guruswamy</creator><creator>MADDI, Raghavender Reddy</creator><creator>BINGI, Hariprasad Reddy</creator><creator>MEENAKSHISUNDERAM, Sivakumaran</creator><scope>EVB</scope></search><sort><creationdate>20190606</creationdate><title>A PROCESS FOR THE PREPARATION OF CARIPRAZINE HYDROCHLORIDE</title><author>NEELA, Praveen Kumar ; SANKINENI, Sampath Kumar ; BATTHINI, Guruswamy ; MADDI, Raghavender Reddy ; BINGI, Hariprasad Reddy ; MEENAKSHISUNDERAM, Sivakumaran</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2019106490A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2019</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>NEELA, Praveen Kumar</creatorcontrib><creatorcontrib>SANKINENI, Sampath Kumar</creatorcontrib><creatorcontrib>BATTHINI, Guruswamy</creatorcontrib><creatorcontrib>MADDI, Raghavender Reddy</creatorcontrib><creatorcontrib>BINGI, Hariprasad Reddy</creatorcontrib><creatorcontrib>MEENAKSHISUNDERAM, Sivakumaran</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>NEELA, Praveen Kumar</au><au>SANKINENI, Sampath Kumar</au><au>BATTHINI, Guruswamy</au><au>MADDI, Raghavender Reddy</au><au>BINGI, Hariprasad Reddy</au><au>MEENAKSHISUNDERAM, Sivakumaran</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>A PROCESS FOR THE PREPARATION OF CARIPRAZINE HYDROCHLORIDE</title><date>2019-06-06</date><risdate>2019</risdate><abstract>The present invention is directed towards a process for the preparation of Cariprazine (Ia) or a pharmaceutically acceptable salt thereof, wherein, N,N- dimethyl-1H-imidazole-1-carboxamide alkyl halide (VII) is reacted with trans-4- (2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexanamine or a salt thereof (IIa) to produce Cariprazine (Ia) or a pharmaceutically acceptable salt thereof. The present invention is also directed towards amorphous form of Cariprazine hydrochloride (I) and solid dispersion of Cariprazine hydrochloride (I), and its preparation thereof.
La présente invention concerne un procédé de préparation de cariprazine (Ia) ou d'un sel pharmaceutiquement acceptable de celle-ci, l'halogénure d'alkyle de N,N-diméthyl-1H-imidazole-1-carboxamide (VII) étant mis à réagir avec du trans-4-(2-(4-(2,3-dichlorophényl)pipérazin-1-yl)éthyl)cyclohexanamine ou un sel de celle-ci (IIa) pour produire la cariprazine (Ia) ou un sel pharmaceutiquement acceptable de celle-ci. La présente invention concerne également une forme amorphe du chlorhydrate de cariprazine (I) et une dispersion solide du chlorhydrate de cariprazine (I), ainsi qu'une préparation correspondante.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | A PROCESS FOR THE PREPARATION OF CARIPRAZINE HYDROCHLORIDE |
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