CYTOKINE-FREE ADJUVANTS FOR CELL CULTURE MEDIA, IN PARTICULAR FOR IN VITRO FERTILISATION, OR FOR THE CULTURE OF FOLLICLES, MALE GERM CELLS OR EMBRYOS
The subject matter of the present invention is compositions that can be used as adjuvants for in vitro cell culture, characterized in that they comprise at least two compounds chosen from the group consisting of a zinc salt, inositol in any one of the stereoisomeric forms thereof, carnitine or a car...
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| creator | CHOAY, Patrick BIDRI, Mohamed |
| description | The subject matter of the present invention is compositions that can be used as adjuvants for in vitro cell culture, characterized in that they comprise at least two compounds chosen from the group consisting of a zinc salt, inositol in any one of the stereoisomeric forms thereof, carnitine or a carnitine derivative, melatonin or an analogue, cystine in one of the stereoisomeric forms thereof or in derivative form, cysteamine or a cysteamine salt, and a corticosteroid, preferably hydrocortisone P, said compositions being free of cytokines. The subject matter of the invention is also methods for in vitro fertilisation and methods for the maturation of follicles, of male germ cells or of embryos using such culture medium adjuvants, and also kits for carrying out these methods which comprise an abovementioned lyophilisate and an aqueous solution, containing the other constituents of said culture media.
La présente invention a pour objet des compositions utilisables comme adjuvants pour la culture in vitro de cellules, caractérisées en ce qu'elles comprennent au moins deux composés choisis parmi le groupe constitué par un sel de zinc, l'inositol sous l'une quelconque de ses formes stéréoisomériques, la carnitine ou un dérivé de la carnitine, la mélatonine ou un analogue, la cystine sous l'une de ses formes stéréoisomériques ou sous forme de dérivé, la cystéamine ou un sel de cystéamine, un corticoïde de préférence P hydrocortisone, lesdites compositions étant dépourvues de cytokines. L'invention a également pour objet des procédés de fécondation in vitro et des procédés de maturation de follicules, de cellules germinales mâles, ou d'embryons utilisant de tels adjuvants de milieux de culture, ainsi que des kits pour la mise en œuvre de ces procédés et comprenant un lyophilisât susmentionné et une solution aqueuse, contenant les autres constituants desdits milieux de culture. |
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La présente invention a pour objet des compositions utilisables comme adjuvants pour la culture in vitro de cellules, caractérisées en ce qu'elles comprennent au moins deux composés choisis parmi le groupe constitué par un sel de zinc, l'inositol sous l'une quelconque de ses formes stéréoisomériques, la carnitine ou un dérivé de la carnitine, la mélatonine ou un analogue, la cystine sous l'une de ses formes stéréoisomériques ou sous forme de dérivé, la cystéamine ou un sel de cystéamine, un corticoïde de préférence P hydrocortisone, lesdites compositions étant dépourvues de cytokines. L'invention a également pour objet des procédés de fécondation in vitro et des procédés de maturation de follicules, de cellules germinales mâles, ou d'embryons utilisant de tels adjuvants de milieux de culture, ainsi que des kits pour la mise en œuvre de ces procédés et comprenant un lyophilisât susmentionné et une solution aqueuse, contenant les autres constituants desdits milieux de culture.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20181018&DB=EPODOC&CC=WO&NR=2018189436A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20181018&DB=EPODOC&CC=WO&NR=2018189436A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHOAY, Patrick</creatorcontrib><creatorcontrib>BIDRI, Mohamed</creatorcontrib><title>CYTOKINE-FREE ADJUVANTS FOR CELL CULTURE MEDIA, IN PARTICULAR FOR IN VITRO FERTILISATION, OR FOR THE CULTURE OF FOLLICLES, MALE GERM CELLS OR EMBRYOS</title><description>The subject matter of the present invention is compositions that can be used as adjuvants for in vitro cell culture, characterized in that they comprise at least two compounds chosen from the group consisting of a zinc salt, inositol in any one of the stereoisomeric forms thereof, carnitine or a carnitine derivative, melatonin or an analogue, cystine in one of the stereoisomeric forms thereof or in derivative form, cysteamine or a cysteamine salt, and a corticosteroid, preferably hydrocortisone P, said compositions being free of cytokines. The subject matter of the invention is also methods for in vitro fertilisation and methods for the maturation of follicles, of male germ cells or of embryos using such culture medium adjuvants, and also kits for carrying out these methods which comprise an abovementioned lyophilisate and an aqueous solution, containing the other constituents of said culture media.
La présente invention a pour objet des compositions utilisables comme adjuvants pour la culture in vitro de cellules, caractérisées en ce qu'elles comprennent au moins deux composés choisis parmi le groupe constitué par un sel de zinc, l'inositol sous l'une quelconque de ses formes stéréoisomériques, la carnitine ou un dérivé de la carnitine, la mélatonine ou un analogue, la cystine sous l'une de ses formes stéréoisomériques ou sous forme de dérivé, la cystéamine ou un sel de cystéamine, un corticoïde de préférence P hydrocortisone, lesdites compositions étant dépourvues de cytokines. L'invention a également pour objet des procédés de fécondation in vitro et des procédés de maturation de follicules, de cellules germinales mâles, ou d'embryons utilisant de tels adjuvants de milieux de culture, ainsi que des kits pour la mise en œuvre de ces procédés et comprenant un lyophilisât susmentionné et une solution aqueuse, contenant les autres constituants desdits milieux de culture.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjb0KwjAUhbs4iPoOF1xbsFakjjG9sdE0kSStdCpF4iRaqK_i-xqrODsd-M7fOHjS2qoDlxgxjQgk25cVkdYAUxooCgG0FLbUCAVmnITAJRyJttxjooeUJxW3WgFDzwU3xHIlQ1Af2-b421DMIyE4FWhCKIhA2KEuhiPzLmCx1bUy02B0aa-9m311EswZWppHrrs3ru_as7u5R3NSy0WcxulmlaxJnPyXegFcm0Jv</recordid><startdate>20181018</startdate><enddate>20181018</enddate><creator>CHOAY, Patrick</creator><creator>BIDRI, Mohamed</creator><scope>EVB</scope></search><sort><creationdate>20181018</creationdate><title>CYTOKINE-FREE ADJUVANTS FOR CELL CULTURE MEDIA, IN PARTICULAR FOR IN VITRO FERTILISATION, OR FOR THE CULTURE OF FOLLICLES, MALE GERM CELLS OR EMBRYOS</title><author>CHOAY, Patrick ; BIDRI, Mohamed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2018189436A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2018</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>CHOAY, Patrick</creatorcontrib><creatorcontrib>BIDRI, Mohamed</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHOAY, Patrick</au><au>BIDRI, Mohamed</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CYTOKINE-FREE ADJUVANTS FOR CELL CULTURE MEDIA, IN PARTICULAR FOR IN VITRO FERTILISATION, OR FOR THE CULTURE OF FOLLICLES, MALE GERM CELLS OR EMBRYOS</title><date>2018-10-18</date><risdate>2018</risdate><abstract>The subject matter of the present invention is compositions that can be used as adjuvants for in vitro cell culture, characterized in that they comprise at least two compounds chosen from the group consisting of a zinc salt, inositol in any one of the stereoisomeric forms thereof, carnitine or a carnitine derivative, melatonin or an analogue, cystine in one of the stereoisomeric forms thereof or in derivative form, cysteamine or a cysteamine salt, and a corticosteroid, preferably hydrocortisone P, said compositions being free of cytokines. The subject matter of the invention is also methods for in vitro fertilisation and methods for the maturation of follicles, of male germ cells or of embryos using such culture medium adjuvants, and also kits for carrying out these methods which comprise an abovementioned lyophilisate and an aqueous solution, containing the other constituents of said culture media.
La présente invention a pour objet des compositions utilisables comme adjuvants pour la culture in vitro de cellules, caractérisées en ce qu'elles comprennent au moins deux composés choisis parmi le groupe constitué par un sel de zinc, l'inositol sous l'une quelconque de ses formes stéréoisomériques, la carnitine ou un dérivé de la carnitine, la mélatonine ou un analogue, la cystine sous l'une de ses formes stéréoisomériques ou sous forme de dérivé, la cystéamine ou un sel de cystéamine, un corticoïde de préférence P hydrocortisone, lesdites compositions étant dépourvues de cytokines. L'invention a également pour objet des procédés de fécondation in vitro et des procédés de maturation de follicules, de cellules germinales mâles, ou d'embryons utilisant de tels adjuvants de milieux de culture, ainsi que des kits pour la mise en œuvre de ces procédés et comprenant un lyophilisât susmentionné et une solution aqueuse, contenant les autres constituants desdits milieux de culture.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | CYTOKINE-FREE ADJUVANTS FOR CELL CULTURE MEDIA, IN PARTICULAR FOR IN VITRO FERTILISATION, OR FOR THE CULTURE OF FOLLICLES, MALE GERM CELLS OR EMBRYOS |
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