POROUS NANOPARTICLE-SUPPORTED LIPID BILAYER DELIVERY OF TRANSCRIPTIONAL GENE MODULATORS

A porous protocell is provided comprising one or more non-integrating vectors comprising nucleic acid encoding a non-nucleolytic fusion protein comprising a protein sequence that specifically binds a sequence in a double strand nucleic acid molecule linked to a protein sequence that is a transcripti...

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Hauptverfasser: BRINKER, Charles Jeffrey, BUTLER, Kimberly, AGOLA, Jacob Ongudi, MUNIZ, Ayse
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Sprache:eng ; fre
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creator BRINKER, Charles Jeffrey
BUTLER, Kimberly
AGOLA, Jacob Ongudi
MUNIZ, Ayse
description A porous protocell is provided comprising one or more non-integrating vectors comprising nucleic acid encoding a non-nucleolytic fusion protein comprising a protein sequence that specifically binds a sequence in a double strand nucleic acid molecule linked to a protein sequence that is a transcriptional mediator, and optionally guide RNA or a vector for expression of guide RNA, and methods of using the protocells. L'invention concerne une protocellule poreuse comprenant un ou plusieurs vecteurs non intégrants comprenant un acide nucléique codant pour une protéine de fusion non nucléolytique comprenant une séquence de protéines qui se lie spécifiquement à une séquence dans une molécule d'acide nucléique à double brin liée à une séquence de protéines qui est un médiateur de transcription, et éventuellement un ARN guide ou un vecteur d'expression d'ARN guide, et des procédés d'utilisation des protocellules.
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language eng ; fre
recordid cdi_epo_espacenet_WO2018187287A1
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subjects BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
NANOTECHNOLOGY
PERFORMING OPERATIONS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
SPIRITS
TRANSPORTING
VINEGAR
WINE
title POROUS NANOPARTICLE-SUPPORTED LIPID BILAYER DELIVERY OF TRANSCRIPTIONAL GENE MODULATORS
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