POROUS NANOPARTICLE-SUPPORTED LIPID BILAYER DELIVERY OF TRANSCRIPTIONAL GENE MODULATORS
A porous protocell is provided comprising one or more non-integrating vectors comprising nucleic acid encoding a non-nucleolytic fusion protein comprising a protein sequence that specifically binds a sequence in a double strand nucleic acid molecule linked to a protein sequence that is a transcripti...
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| creator | BRINKER, Charles Jeffrey BUTLER, Kimberly AGOLA, Jacob Ongudi MUNIZ, Ayse |
| description | A porous protocell is provided comprising one or more non-integrating vectors comprising nucleic acid encoding a non-nucleolytic fusion protein comprising a protein sequence that specifically binds a sequence in a double strand nucleic acid molecule linked to a protein sequence that is a transcriptional mediator, and optionally guide RNA or a vector for expression of guide RNA, and methods of using the protocells.
L'invention concerne une protocellule poreuse comprenant un ou plusieurs vecteurs non intégrants comprenant un acide nucléique codant pour une protéine de fusion non nucléolytique comprenant une séquence de protéines qui se lie spécifiquement à une séquence dans une molécule d'acide nucléique à double brin liée à une séquence de protéines qui est un médiateur de transcription, et éventuellement un ARN guide ou un vecteur d'expression d'ARN guide, et des procédés d'utilisation des protocellules. |
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L'invention concerne une protocellule poreuse comprenant un ou plusieurs vecteurs non intégrants comprenant un acide nucléique codant pour une protéine de fusion non nucléolytique comprenant une séquence de protéines qui se lie spécifiquement à une séquence dans une molécule d'acide nucléique à double brin liée à une séquence de protéines qui est un médiateur de transcription, et éventuellement un ARN guide ou un vecteur d'expression d'ARN guide, et des procédés d'utilisation des protocellules.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES ; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; NANOTECHNOLOGY ; PERFORMING OPERATIONS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES ; SPIRITS ; TRANSPORTING ; VINEGAR ; WINE</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20181011&DB=EPODOC&CC=WO&NR=2018187287A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,782,887,25571,76555</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20181011&DB=EPODOC&CC=WO&NR=2018187287A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BRINKER, Charles Jeffrey</creatorcontrib><creatorcontrib>BUTLER, Kimberly</creatorcontrib><creatorcontrib>AGOLA, Jacob Ongudi</creatorcontrib><creatorcontrib>MUNIZ, Ayse</creatorcontrib><title>POROUS NANOPARTICLE-SUPPORTED LIPID BILAYER DELIVERY OF TRANSCRIPTIONAL GENE MODULATORS</title><description>A porous protocell is provided comprising one or more non-integrating vectors comprising nucleic acid encoding a non-nucleolytic fusion protein comprising a protein sequence that specifically binds a sequence in a double strand nucleic acid molecule linked to a protein sequence that is a transcriptional mediator, and optionally guide RNA or a vector for expression of guide RNA, and methods of using the protocells.
L'invention concerne une protocellule poreuse comprenant un ou plusieurs vecteurs non intégrants comprenant un acide nucléique codant pour une protéine de fusion non nucléolytique comprenant une séquence de protéines qui se lie spécifiquement à une séquence dans une molécule d'acide nucléique à double brin liée à une séquence de protéines qui est un médiateur de transcription, et éventuellement un ARN guide ou un vecteur d'expression d'ARN guide, et des procédés d'utilisation des protocellules.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MANUFACTURE OR TREATMENT OF NANOSTRUCTURES</subject><subject>MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>NANOTECHNOLOGY</subject><subject>PERFORMING OPERATIONS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES</subject><subject>SPIRITS</subject><subject>TRANSPORTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrEKwjAQgOEuDqK-w4FzwdbBrmdz1YOYC5fU0qkUiZNoob4_OvgATj98_Mus86LSBnDoxKNGri3lofVfjmTAsmcDR7bYk4Ihy1fSHqSBqOhCrewji0MLJ3IEFzGtxSga1tniPj7mtPl1lW0bivU5T9NrSPM03tIzvYdOyl1RFdWhrA5Y7P-7PvC7Mro</recordid><startdate>20181011</startdate><enddate>20181011</enddate><creator>BRINKER, Charles Jeffrey</creator><creator>BUTLER, Kimberly</creator><creator>AGOLA, Jacob Ongudi</creator><creator>MUNIZ, Ayse</creator><scope>EVB</scope></search><sort><creationdate>20181011</creationdate><title>POROUS NANOPARTICLE-SUPPORTED LIPID BILAYER DELIVERY OF TRANSCRIPTIONAL GENE MODULATORS</title><author>BRINKER, Charles Jeffrey ; BUTLER, Kimberly ; AGOLA, Jacob Ongudi ; MUNIZ, Ayse</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2018187287A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2018</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MANUFACTURE OR TREATMENT OF NANOSTRUCTURES</topic><topic>MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>NANOTECHNOLOGY</topic><topic>PERFORMING OPERATIONS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES</topic><topic>SPIRITS</topic><topic>TRANSPORTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>BRINKER, Charles Jeffrey</creatorcontrib><creatorcontrib>BUTLER, Kimberly</creatorcontrib><creatorcontrib>AGOLA, Jacob Ongudi</creatorcontrib><creatorcontrib>MUNIZ, Ayse</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BRINKER, Charles Jeffrey</au><au>BUTLER, Kimberly</au><au>AGOLA, Jacob Ongudi</au><au>MUNIZ, Ayse</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>POROUS NANOPARTICLE-SUPPORTED LIPID BILAYER DELIVERY OF TRANSCRIPTIONAL GENE MODULATORS</title><date>2018-10-11</date><risdate>2018</risdate><abstract>A porous protocell is provided comprising one or more non-integrating vectors comprising nucleic acid encoding a non-nucleolytic fusion protein comprising a protein sequence that specifically binds a sequence in a double strand nucleic acid molecule linked to a protein sequence that is a transcriptional mediator, and optionally guide RNA or a vector for expression of guide RNA, and methods of using the protocells.
L'invention concerne une protocellule poreuse comprenant un ou plusieurs vecteurs non intégrants comprenant un acide nucléique codant pour une protéine de fusion non nucléolytique comprenant une séquence de protéines qui se lie spécifiquement à une séquence dans une molécule d'acide nucléique à double brin liée à une séquence de protéines qui est un médiateur de transcription, et éventuellement un ARN guide ou un vecteur d'expression d'ARN guide, et des procédés d'utilisation des protocellules.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MANUFACTURE OR TREATMENT OF NANOSTRUCTURES MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NANOTECHNOLOGY PERFORMING OPERATIONS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES SPIRITS TRANSPORTING VINEGAR WINE |
| title | POROUS NANOPARTICLE-SUPPORTED LIPID BILAYER DELIVERY OF TRANSCRIPTIONAL GENE MODULATORS |
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