AN IMPROVED PROCESS FOR PREPARATION AND PURIFICATION OF VORTIOXETINE HYDROBROMIDE
The present invention is related to an improved process for the preparation and purification of crystalline polymorph of Vortioxetine hydrobromide of Formula-I and Vortioxetine hydrochloride of Formula-Ia. The process according to present invention is operationally simple and suitable for industrial...
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| creator | KULKARNI, Vishal SATHE, Dhananjay D PATIL, Yogesh NAGAWADE, Prafulla DAS, Arijit PATIL, Tushar |
| description | The present invention is related to an improved process for the preparation and purification of crystalline polymorph of Vortioxetine hydrobromide of Formula-I and Vortioxetine hydrochloride of Formula-Ia. The process according to present invention is operationally simple and suitable for industrial application which will avoid hazardous chemicals and eliminate column chromatography to get ICH quality of pharmaceutically acceptable active pharmaceutical ingredient having snow white appearance.
La présente invention concerne un procédé amélioré de préparation et de purification de polymorphes cristallins de bromhydrate de vortioxétine de formule-I et de chlorhydrate de vortioxétine de formule-Ia. Le procédé selon la présente invention est fonctionnellement simple et approprié pour une application industrielle qui évite d'utiliser des produits chimiques dangereux et supprime la chromatographie sur colonne pour obtenir une qualité ICH d'un principe actif pharmaceutique pharmaceutiquement acceptable d'un aspect blanc neige. |
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La présente invention concerne un procédé amélioré de préparation et de purification de polymorphes cristallins de bromhydrate de vortioxétine de formule-I et de chlorhydrate de vortioxétine de formule-Ia. Le procédé selon la présente invention est fonctionnellement simple et approprié pour une application industrielle qui évite d'utiliser des produits chimiques dangereux et supprime la chromatographie sur colonne pour obtenir une qualité ICH d'un principe actif pharmaceutique pharmaceutiquement acceptable d'un aspect blanc neige.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180830&DB=EPODOC&CC=WO&NR=2018154451A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180830&DB=EPODOC&CC=WO&NR=2018154451A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KULKARNI, Vishal</creatorcontrib><creatorcontrib>SATHE, Dhananjay D</creatorcontrib><creatorcontrib>PATIL, Yogesh</creatorcontrib><creatorcontrib>NAGAWADE, Prafulla</creatorcontrib><creatorcontrib>DAS, Arijit</creatorcontrib><creatorcontrib>PATIL, Tushar</creatorcontrib><title>AN IMPROVED PROCESS FOR PREPARATION AND PURIFICATION OF VORTIOXETINE HYDROBROMIDE</title><description>The present invention is related to an improved process for the preparation and purification of crystalline polymorph of Vortioxetine hydrobromide of Formula-I and Vortioxetine hydrochloride of Formula-Ia. The process according to present invention is operationally simple and suitable for industrial application which will avoid hazardous chemicals and eliminate column chromatography to get ICH quality of pharmaceutically acceptable active pharmaceutical ingredient having snow white appearance.
La présente invention concerne un procédé amélioré de préparation et de purification de polymorphes cristallins de bromhydrate de vortioxétine de formule-I et de chlorhydrate de vortioxétine de formule-Ia. Le procédé selon la présente invention est fonctionnellement simple et approprié pour une application industrielle qui évite d'utiliser des produits chimiques dangereux et supprime la chromatographie sur colonne pour obtenir une qualité ICH d'un principe actif pharmaceutique pharmaceutiquement acceptable d'un aspect blanc neige.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZAh09FPw9A0I8g9zdVEAUs6uwcEKbv5BQLZrgGOQY4inv5-Cox9QLjTI083TGSLg76YQ5h8EZEa4hnj6uSp4RLoE-TsF-ft6urjyMLCmJeYUp_JCaW4GZTfXEGcP3dSC_PjU4oLE5NS81JL4cH8jA0MLQ1MTE1NDR0Nj4lQBAJPlMLM</recordid><startdate>20180830</startdate><enddate>20180830</enddate><creator>KULKARNI, Vishal</creator><creator>SATHE, Dhananjay D</creator><creator>PATIL, Yogesh</creator><creator>NAGAWADE, Prafulla</creator><creator>DAS, Arijit</creator><creator>PATIL, Tushar</creator><scope>EVB</scope></search><sort><creationdate>20180830</creationdate><title>AN IMPROVED PROCESS FOR PREPARATION AND PURIFICATION OF VORTIOXETINE HYDROBROMIDE</title><author>KULKARNI, Vishal ; SATHE, Dhananjay D ; PATIL, Yogesh ; NAGAWADE, Prafulla ; DAS, Arijit ; PATIL, Tushar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2018154451A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2018</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>KULKARNI, Vishal</creatorcontrib><creatorcontrib>SATHE, Dhananjay D</creatorcontrib><creatorcontrib>PATIL, Yogesh</creatorcontrib><creatorcontrib>NAGAWADE, Prafulla</creatorcontrib><creatorcontrib>DAS, Arijit</creatorcontrib><creatorcontrib>PATIL, Tushar</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KULKARNI, Vishal</au><au>SATHE, Dhananjay D</au><au>PATIL, Yogesh</au><au>NAGAWADE, Prafulla</au><au>DAS, Arijit</au><au>PATIL, Tushar</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>AN IMPROVED PROCESS FOR PREPARATION AND PURIFICATION OF VORTIOXETINE HYDROBROMIDE</title><date>2018-08-30</date><risdate>2018</risdate><abstract>The present invention is related to an improved process for the preparation and purification of crystalline polymorph of Vortioxetine hydrobromide of Formula-I and Vortioxetine hydrochloride of Formula-Ia. The process according to present invention is operationally simple and suitable for industrial application which will avoid hazardous chemicals and eliminate column chromatography to get ICH quality of pharmaceutically acceptable active pharmaceutical ingredient having snow white appearance.
La présente invention concerne un procédé amélioré de préparation et de purification de polymorphes cristallins de bromhydrate de vortioxétine de formule-I et de chlorhydrate de vortioxétine de formule-Ia. Le procédé selon la présente invention est fonctionnellement simple et approprié pour une application industrielle qui évite d'utiliser des produits chimiques dangereux et supprime la chromatographie sur colonne pour obtenir une qualité ICH d'un principe actif pharmaceutique pharmaceutiquement acceptable d'un aspect blanc neige.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | AN IMPROVED PROCESS FOR PREPARATION AND PURIFICATION OF VORTIOXETINE HYDROBROMIDE |
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