NOVEL CRYSTALLINE FORMS OF LESINURAD

The present invention provides novel crystalline forms of Lesinurad, pharmaceutical compositions comprising these crystalline forms, and their use in the treatment of hyperuricemia associated with gout. Specific crystalline forms provided by the present invention include Lesinurad Forms APO-I, a hem...

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Bibliographische Detailangaben
Hauptverfasser:	REY, Allan W, GERSTER, Jenny L, GROOM, Katherine A
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides novel crystalline forms of Lesinurad, pharmaceutical compositions comprising these crystalline forms, and their use in the treatment of hyperuricemia associated with gout. Specific crystalline forms provided by the present invention include Lesinurad Forms APO-I, a hemi- methanolate, APO-II, a hemi-ethanolate, and APO-III, a co-crystal of Lesinurad and nicotinamide. La présente invention concerne de nouvelles formes cristallines du Lésinurad, des compositions pharmaceutiques comprenant ces formes cristallines, et leur utilisation dans le traitement de l'hyperuricémie associée à la goutte. Les formes cristallines spécifiques fournies par la présente invention comprennent les formes du Lésinurad que sont l'APO-I, un hémi-méthanolate, l'APO-II, un hémi-éthanolate, et l'APO-III, un co-cristal de Lésinurad et de nicotinamide.