DRY ENTERIC NITROSATION COMPOSITION AND USE

The present invention relates to a dry composition comprising a solid thiol precursor and solid sodium nitrite (NaNO2) incorporated in dry, solid hydrophilic polymer matrices for inducing therein a nitrosation reaction of the thiol precursor following the absorption of water from the gastrointestina...

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Hauptverfasser: DE OLIVEIRA, Marcelo Ganzarolli, DE SOUZA, Gabriela Freitas Pereira
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creator DE OLIVEIRA, Marcelo Ganzarolli
DE SOUZA, Gabriela Freitas Pereira
description The present invention relates to a dry composition comprising a solid thiol precursor and solid sodium nitrite (NaNO2) incorporated in dry, solid hydrophilic polymer matrices for inducing therein a nitrosation reaction of the thiol precursor following the absorption of water from the gastrointestinal environment. The present invention falls within the field of application of medical-pharmaceutical sciences, more specifically of medicinal preparations characterized by special physical forms. La présente invention concerne une composition sèche comprenant un thiol précurseur et du nitrite de sodium (NaNO2) solides incorporés dans des matrices polymères hydrophiles solides et sèches pour favoriser intérieurement la réaction de nitrosation du thio précurseur à partir de l'absorption d'eau en provenance du milieu gastro-intestinal. La présente invention relève du domaine d'application des sciences médico-pharmaceutiques, et notamment des préparations médicales caractérisées par des formes physiques spéciales. A presente invenção se refere a uma composição seca que compreende um tiol precursor e nitrito de sódio (NaNO2) sólidos incorporados em matrizes poliméricas hidrofílicas sólidas e secas para promover em seu interior a reação de nitrosação do tiol precursor a partir da absorção de agua proveniente do meio gastrointestinal. A presente invenção se insere no campo de aplicação das ciências médico-farmacêuticas, mais especificamente, das preparações medicinais caracterizadas por formas físicas especíais.
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
COMPOUNDS THEREOF
HUMAN NECESSITIES
HYGIENE
INORGANIC CHEMISTRY
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NON-METALLIC ELEMENTS
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title DRY ENTERIC NITROSATION COMPOSITION AND USE
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