COMPOSITION FOR PREVENTING OR TREATING PULMONARY FIBROSIS INCLUDING EXOSOME EXTRACTED FROM ADIPOSE-DERIVED STEM CELL AS ACTIVE COMPONENT

COMPOSITION FOR PREVENTING OR TREATING PULMONARY FIBROSIS INCLUDING EXOSOME EXTRACTED FROM ADIPOSE-DERIVED STEM CELL AS ACTIVE COMPONENT

The present invention relates to: a composition, which is for preventing or treating pulmonary fibrosis and includes an exosome extracted from an adipose-derived stem cell as an active component; a use of the exosome in the preparation of a pharmaceutical for preventing or treating pulmonary fibrosi...

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Hauptverfasser: CHO, Yong Woo, YEOM, Seung Ho, CHOI, Ji Suk, JUNG, Youn Jae
Format: Patent
Sprache:eng ; fre ; kor
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator CHO, Yong Woo
YEOM, Seung Ho
CHOI, Ji Suk
JUNG, Youn Jae
description The present invention relates to: a composition, which is for preventing or treating pulmonary fibrosis and includes an exosome extracted from an adipose-derived stem cell as an active component; a use of the exosome in the preparation of a pharmaceutical for preventing or treating pulmonary fibrosis; and a pulmonary fibrosis treatment method including a step for administering a subject with a pharmaceutical composition including the exosome as an active component. An exosome extracted from an adipose-derived stem cell according to the present invention includes growth factors, such as HGF (hepatocyte growth factor) and IL-10, related to pulmonary fibrosis treatment, and can significantly reduce the fibrotic region in pulmonary fibrosis-induced test animal models, and thus, can be usefully used in the prevention or treatment of pulmonary fibrosis. Moreover, in a pulmonary fibrosis treatment using an exosome according to the present invention, there is little concern of side effects from steroid-based drugs and antioxidants used in typical pulmonary fibrosis treatments occuring, and exosomes can be naturally transported to the lungs through injection- or ingestion-based administration, without surgical treatment, and thus, pulmonary fibrosis can be treated simply and economically. La présente invention concerne : une composition destinée à prévenir ou traiter la fibrose pulmonaire et qui comprend comme principe actif un exosome issu de cellules souches dérivées du tissu adipeux ; une utilisation de l'exosome dans la préparation d'un médicament pour la prévention ou le traitement de la fibrose pulmonaire ; et une méthode de traitement de la fibrose pulmonaire comprenant une étape d'administration au patient d'une composition pharmaceutique comprenant l'exosome comme principe actif. L'exosome issu de cellules souches dérivées du tissu adipeux de la présente invention comprend des facteurs de croissance, tels que le HGF (facteur de croissance des hépatocytes) et l'IL-10, qui sont liés au traitement de la fibrose pulmonaire, et peut faire diminuer de manière significative la zone fibrotique dans des modèles animaux expérimentaux chez lesquels a été induite une fibrose pulmonaire, et peut de ce fait être utilisé dans la prévention ou le traitement de la fibrose pulmonaire. De plus, dans le cas d'un traitement de la fibrose pulmonaire utilisant l'exosome selon la présente invention, il y a peu de risque d'effets secondaires retrouvés avec les médicaments à base d
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fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO2018026203A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO2018026203A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO2018026203A13</originalsourceid><addsrcrecordid>eNqNTUEKwjAQ7MWDqH9Y8FxoK4jXmGw0kGRLklY9lSLxJFqoj_DZxuIDPM3szOzMPHtzMjV5FRRZkOSgdtiiDcoeIF3BIZt43WhDlrkLSLV36cGDslw34mvimTwZTBgc4wEFSEcGmFCpGnOBTrVJ9AENcNQamIeUSyJM8zYNLrPZrb-PcfXDRbaWGPgxj8Ozi-PQX-MjvroTVUW5K6ptVWxYufkv9QHNrz_Z</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>COMPOSITION FOR PREVENTING OR TREATING PULMONARY FIBROSIS INCLUDING EXOSOME EXTRACTED FROM ADIPOSE-DERIVED STEM CELL AS ACTIVE COMPONENT</title><source>esp@cenet</source><creator>CHO, Yong Woo ; YEOM, Seung Ho ; CHOI, Ji Suk ; JUNG, Youn Jae</creator><creatorcontrib>CHO, Yong Woo ; YEOM, Seung Ho ; CHOI, Ji Suk ; JUNG, Youn Jae</creatorcontrib><description>The present invention relates to: a composition, which is for preventing or treating pulmonary fibrosis and includes an exosome extracted from an adipose-derived stem cell as an active component; a use of the exosome in the preparation of a pharmaceutical for preventing or treating pulmonary fibrosis; and a pulmonary fibrosis treatment method including a step for administering a subject with a pharmaceutical composition including the exosome as an active component. An exosome extracted from an adipose-derived stem cell according to the present invention includes growth factors, such as HGF (hepatocyte growth factor) and IL-10, related to pulmonary fibrosis treatment, and can significantly reduce the fibrotic region in pulmonary fibrosis-induced test animal models, and thus, can be usefully used in the prevention or treatment of pulmonary fibrosis. Moreover, in a pulmonary fibrosis treatment using an exosome according to the present invention, there is little concern of side effects from steroid-based drugs and antioxidants used in typical pulmonary fibrosis treatments occuring, and exosomes can be naturally transported to the lungs through injection- or ingestion-based administration, without surgical treatment, and thus, pulmonary fibrosis can be treated simply and economically. La présente invention concerne : une composition destinée à prévenir ou traiter la fibrose pulmonaire et qui comprend comme principe actif un exosome issu de cellules souches dérivées du tissu adipeux ; une utilisation de l'exosome dans la préparation d'un médicament pour la prévention ou le traitement de la fibrose pulmonaire ; et une méthode de traitement de la fibrose pulmonaire comprenant une étape d'administration au patient d'une composition pharmaceutique comprenant l'exosome comme principe actif. L'exosome issu de cellules souches dérivées du tissu adipeux de la présente invention comprend des facteurs de croissance, tels que le HGF (facteur de croissance des hépatocytes) et l'IL-10, qui sont liés au traitement de la fibrose pulmonaire, et peut faire diminuer de manière significative la zone fibrotique dans des modèles animaux expérimentaux chez lesquels a été induite une fibrose pulmonaire, et peut de ce fait être utilisé dans la prévention ou le traitement de la fibrose pulmonaire. De plus, dans le cas d'un traitement de la fibrose pulmonaire utilisant l'exosome selon la présente invention, il y a peu de risque d'effets secondaires retrouvés avec les médicaments à base de stéroïdes et avec les antioxydants utilisés dans des traitements classiques de la fibrose pulmonaire, et des exosomes peuvent être naturellement transportés vers les poumons par une administration de type injection ou ingestion, sans traitement chirurgical, et la fibrose pulmonaire peut de ce fait être traitée de manière simple et économique. 본 발명은 지방 유래 줄기세포로부터 추출된 엑소좀을 유효성분으로 포함하는 폐 섬유증 예방 또는 치료용 조성물, 폐 섬유증 예방 또는 치료를 위한 의약품의 제조에 있어서의 상기 엑소좀의 용도, 및 상기 엑소좀을 유효성분으로 포함하는 약학적 조성물을 대상체에게 투여하는 단계를 포함하는 폐 섬유증 치료 방법에 관한 것이다. 본 발명에 따른 지방 유래 줄기세포로부터 추출된 엑소좀은 폐 섬유증 치료에 관련된 HGF(hepatocyte growth factor) 및 IL-10과 같은 성장인자를 포함하며, 폐 섬유증 유도 실험동물 모델에서 섬유화 영역을 현저히 감소시킬 수 있으므로 폐 섬유증 예방 또는 치료에 유용하게 이용될 수 있다. 또한, 본 발명에 따른 엑소좀을 이용한 폐 섬유증 치료는 기존 폐 섬유증 치료에 사용되던 스테로이드계 약물 및 항산화제에 의해 유발되는 부작용 발생 우려가 적고, 수술 치료 없이 주사 투여 방식, 흡입 투여 방식 등을 통해 자연적으로 폐에 엑소좀을 전달할 수 있으므로, 간편하고 경제적으로 폐 섬유증을 치료할 수 있다.</description><language>eng ; fre ; kor</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20180208&amp;DB=EPODOC&amp;CC=WO&amp;NR=2018026203A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25569,76552</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20180208&amp;DB=EPODOC&amp;CC=WO&amp;NR=2018026203A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHO, Yong Woo</creatorcontrib><creatorcontrib>YEOM, Seung Ho</creatorcontrib><creatorcontrib>CHOI, Ji Suk</creatorcontrib><creatorcontrib>JUNG, Youn Jae</creatorcontrib><title>COMPOSITION FOR PREVENTING OR TREATING PULMONARY FIBROSIS INCLUDING EXOSOME EXTRACTED FROM ADIPOSE-DERIVED STEM CELL AS ACTIVE COMPONENT</title><description>The present invention relates to: a composition, which is for preventing or treating pulmonary fibrosis and includes an exosome extracted from an adipose-derived stem cell as an active component; a use of the exosome in the preparation of a pharmaceutical for preventing or treating pulmonary fibrosis; and a pulmonary fibrosis treatment method including a step for administering a subject with a pharmaceutical composition including the exosome as an active component. An exosome extracted from an adipose-derived stem cell according to the present invention includes growth factors, such as HGF (hepatocyte growth factor) and IL-10, related to pulmonary fibrosis treatment, and can significantly reduce the fibrotic region in pulmonary fibrosis-induced test animal models, and thus, can be usefully used in the prevention or treatment of pulmonary fibrosis. Moreover, in a pulmonary fibrosis treatment using an exosome according to the present invention, there is little concern of side effects from steroid-based drugs and antioxidants used in typical pulmonary fibrosis treatments occuring, and exosomes can be naturally transported to the lungs through injection- or ingestion-based administration, without surgical treatment, and thus, pulmonary fibrosis can be treated simply and economically. La présente invention concerne : une composition destinée à prévenir ou traiter la fibrose pulmonaire et qui comprend comme principe actif un exosome issu de cellules souches dérivées du tissu adipeux ; une utilisation de l'exosome dans la préparation d'un médicament pour la prévention ou le traitement de la fibrose pulmonaire ; et une méthode de traitement de la fibrose pulmonaire comprenant une étape d'administration au patient d'une composition pharmaceutique comprenant l'exosome comme principe actif. L'exosome issu de cellules souches dérivées du tissu adipeux de la présente invention comprend des facteurs de croissance, tels que le HGF (facteur de croissance des hépatocytes) et l'IL-10, qui sont liés au traitement de la fibrose pulmonaire, et peut faire diminuer de manière significative la zone fibrotique dans des modèles animaux expérimentaux chez lesquels a été induite une fibrose pulmonaire, et peut de ce fait être utilisé dans la prévention ou le traitement de la fibrose pulmonaire. De plus, dans le cas d'un traitement de la fibrose pulmonaire utilisant l'exosome selon la présente invention, il y a peu de risque d'effets secondaires retrouvés avec les médicaments à base de stéroïdes et avec les antioxydants utilisés dans des traitements classiques de la fibrose pulmonaire, et des exosomes peuvent être naturellement transportés vers les poumons par une administration de type injection ou ingestion, sans traitement chirurgical, et la fibrose pulmonaire peut de ce fait être traitée de manière simple et économique. 본 발명은 지방 유래 줄기세포로부터 추출된 엑소좀을 유효성분으로 포함하는 폐 섬유증 예방 또는 치료용 조성물, 폐 섬유증 예방 또는 치료를 위한 의약품의 제조에 있어서의 상기 엑소좀의 용도, 및 상기 엑소좀을 유효성분으로 포함하는 약학적 조성물을 대상체에게 투여하는 단계를 포함하는 폐 섬유증 치료 방법에 관한 것이다. 본 발명에 따른 지방 유래 줄기세포로부터 추출된 엑소좀은 폐 섬유증 치료에 관련된 HGF(hepatocyte growth factor) 및 IL-10과 같은 성장인자를 포함하며, 폐 섬유증 유도 실험동물 모델에서 섬유화 영역을 현저히 감소시킬 수 있으므로 폐 섬유증 예방 또는 치료에 유용하게 이용될 수 있다. 또한, 본 발명에 따른 엑소좀을 이용한 폐 섬유증 치료는 기존 폐 섬유증 치료에 사용되던 스테로이드계 약물 및 항산화제에 의해 유발되는 부작용 발생 우려가 적고, 수술 치료 없이 주사 투여 방식, 흡입 투여 방식 등을 통해 자연적으로 폐에 엑소좀을 전달할 수 있으므로, 간편하고 경제적으로 폐 섬유증을 치료할 수 있다.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNTUEKwjAQ7MWDqH9Y8FxoK4jXmGw0kGRLklY9lSLxJFqoj_DZxuIDPM3szOzMPHtzMjV5FRRZkOSgdtiiDcoeIF3BIZt43WhDlrkLSLV36cGDslw34mvimTwZTBgc4wEFSEcGmFCpGnOBTrVJ9AENcNQamIeUSyJM8zYNLrPZrb-PcfXDRbaWGPgxj8Ozi-PQX-MjvroTVUW5K6ptVWxYufkv9QHNrz_Z</recordid><startdate>20180208</startdate><enddate>20180208</enddate><creator>CHO, Yong Woo</creator><creator>YEOM, Seung Ho</creator><creator>CHOI, Ji Suk</creator><creator>JUNG, Youn Jae</creator><scope>EVB</scope></search><sort><creationdate>20180208</creationdate><title>COMPOSITION FOR PREVENTING OR TREATING PULMONARY FIBROSIS INCLUDING EXOSOME EXTRACTED FROM ADIPOSE-DERIVED STEM CELL AS ACTIVE COMPONENT</title><author>CHO, Yong Woo ; YEOM, Seung Ho ; CHOI, Ji Suk ; JUNG, Youn Jae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2018026203A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; kor</language><creationdate>2018</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>CHO, Yong Woo</creatorcontrib><creatorcontrib>YEOM, Seung Ho</creatorcontrib><creatorcontrib>CHOI, Ji Suk</creatorcontrib><creatorcontrib>JUNG, Youn Jae</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHO, Yong Woo</au><au>YEOM, Seung Ho</au><au>CHOI, Ji Suk</au><au>JUNG, Youn Jae</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPOSITION FOR PREVENTING OR TREATING PULMONARY FIBROSIS INCLUDING EXOSOME EXTRACTED FROM ADIPOSE-DERIVED STEM CELL AS ACTIVE COMPONENT</title><date>2018-02-08</date><risdate>2018</risdate><abstract>The present invention relates to: a composition, which is for preventing or treating pulmonary fibrosis and includes an exosome extracted from an adipose-derived stem cell as an active component; a use of the exosome in the preparation of a pharmaceutical for preventing or treating pulmonary fibrosis; and a pulmonary fibrosis treatment method including a step for administering a subject with a pharmaceutical composition including the exosome as an active component. An exosome extracted from an adipose-derived stem cell according to the present invention includes growth factors, such as HGF (hepatocyte growth factor) and IL-10, related to pulmonary fibrosis treatment, and can significantly reduce the fibrotic region in pulmonary fibrosis-induced test animal models, and thus, can be usefully used in the prevention or treatment of pulmonary fibrosis. Moreover, in a pulmonary fibrosis treatment using an exosome according to the present invention, there is little concern of side effects from steroid-based drugs and antioxidants used in typical pulmonary fibrosis treatments occuring, and exosomes can be naturally transported to the lungs through injection- or ingestion-based administration, without surgical treatment, and thus, pulmonary fibrosis can be treated simply and economically. La présente invention concerne : une composition destinée à prévenir ou traiter la fibrose pulmonaire et qui comprend comme principe actif un exosome issu de cellules souches dérivées du tissu adipeux ; une utilisation de l'exosome dans la préparation d'un médicament pour la prévention ou le traitement de la fibrose pulmonaire ; et une méthode de traitement de la fibrose pulmonaire comprenant une étape d'administration au patient d'une composition pharmaceutique comprenant l'exosome comme principe actif. L'exosome issu de cellules souches dérivées du tissu adipeux de la présente invention comprend des facteurs de croissance, tels que le HGF (facteur de croissance des hépatocytes) et l'IL-10, qui sont liés au traitement de la fibrose pulmonaire, et peut faire diminuer de manière significative la zone fibrotique dans des modèles animaux expérimentaux chez lesquels a été induite une fibrose pulmonaire, et peut de ce fait être utilisé dans la prévention ou le traitement de la fibrose pulmonaire. De plus, dans le cas d'un traitement de la fibrose pulmonaire utilisant l'exosome selon la présente invention, il y a peu de risque d'effets secondaires retrouvés avec les médicaments à base de stéroïdes et avec les antioxydants utilisés dans des traitements classiques de la fibrose pulmonaire, et des exosomes peuvent être naturellement transportés vers les poumons par une administration de type injection ou ingestion, sans traitement chirurgical, et la fibrose pulmonaire peut de ce fait être traitée de manière simple et économique. 본 발명은 지방 유래 줄기세포로부터 추출된 엑소좀을 유효성분으로 포함하는 폐 섬유증 예방 또는 치료용 조성물, 폐 섬유증 예방 또는 치료를 위한 의약품의 제조에 있어서의 상기 엑소좀의 용도, 및 상기 엑소좀을 유효성분으로 포함하는 약학적 조성물을 대상체에게 투여하는 단계를 포함하는 폐 섬유증 치료 방법에 관한 것이다. 본 발명에 따른 지방 유래 줄기세포로부터 추출된 엑소좀은 폐 섬유증 치료에 관련된 HGF(hepatocyte growth factor) 및 IL-10과 같은 성장인자를 포함하며, 폐 섬유증 유도 실험동물 모델에서 섬유화 영역을 현저히 감소시킬 수 있으므로 폐 섬유증 예방 또는 치료에 유용하게 이용될 수 있다. 또한, 본 발명에 따른 엑소좀을 이용한 폐 섬유증 치료는 기존 폐 섬유증 치료에 사용되던 스테로이드계 약물 및 항산화제에 의해 유발되는 부작용 발생 우려가 적고, 수술 치료 없이 주사 투여 방식, 흡입 투여 방식 등을 통해 자연적으로 폐에 엑소좀을 전달할 수 있으므로, 간편하고 경제적으로 폐 섬유증을 치료할 수 있다.</abstract><oa>free_for_read</oa></addata></record>
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HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title COMPOSITION FOR PREVENTING OR TREATING PULMONARY FIBROSIS INCLUDING EXOSOME EXTRACTED FROM ADIPOSE-DERIVED STEM CELL AS ACTIVE COMPONENT
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