TAU PET IMAGING LIGANDS

The present invention relates to novel, selective radiolabelled tau ligands which are useful for imaging and quantifying tau aggregates, using positron-emission tomography (PET). The invention is also directed to compositions comprising such compounds, to processes for preparing such compounds and c...

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Bibliographische Detailangaben
Hauptverfasser:	BORMANS, Guy, Maurits, R, MOECHARS, Diederik, Willem, Elisabeth, LEENAERTS, Joseph, Elisabeth, ROMBOUTS, Frederik, Jan, Rita, KOLB, Hartmuth, ANDRÉS-GIL, José, Ignacio, FIERENS, Katleen, ZHANG, Wei, DECLERCQ, Lieven, Denis, Herwig
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to novel, selective radiolabelled tau ligands which are useful for imaging and quantifying tau aggregates, using positron-emission tomography (PET). The invention is also directed to compositions comprising such compounds, to processes for preparing such compounds and compositions, to the use of such compounds and compositions for imaging a tissue or a subject, in vitro or in vivo, and to precursors of said compounds. L'invention porte sur de nouveaux ligands tau radiomarqués sélectifs, qui sont utiles pour l'imagerie et la quantification d'agrégats de protéines tau, par tomographie par émission de positons (TEP). L'invention porte sur des compositions comprenant lesdits composés, sur leur méthodes de préparation et sur leur utilisation pour l'imagerie d'un tissu ou d'un sujet, in vitro ou in vivo, ainsi que des précurseurs de ces composés.