NOVEL PROCESSES FOR THE PRODUCTION OF OLIGONUCLEOTIDES
Disclosed herein are novel processes for the production of oligonucleotides that are suitable for use in the production of chemically modified oligonucleotides, such as those for use in therapy, said processes comprising: a) providing a template oligonucleotide (I) complimentary to the sequence of t...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | TEW, David Graham LOVELOCK, Sarah Louise SCHOBER, Markus CRAMERI, Andreas THOMAS, Pamela Joan HILL, Malcolm Leithhead |
| description | Disclosed herein are novel processes for the production of oligonucleotides that are suitable for use in the production of chemically modified oligonucleotides, such as those for use in therapy, said processes comprising: a) providing a template oligonucleotide (I) complimentary to the sequence of the product, said template having properties that allow it to be separated from the product; b) providing a pool of oligonucleotides (II); c) contacting (I) and (II) in conditions to allow annealing; d) changing the conditions to separate any impurities, comprising denaturing the annealed template and impurity oligonucleotide strands and separating the impurities; and e) changing the conditions to separate the product, comprising denaturing the annealed template and product oligonucleotide strands and separating the product.
L'invention concerne de nouveaux procédés de production d'oligonucléotides pouvant être utilisés dans la production d'oligonucléotides modifiés chimiquement, tels que ceux utilisés en thérapie. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO2018011067A3</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO2018011067A3</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO2018011067A33</originalsourceid><addsrcrecordid>eNrjZDDz8w9z9VEICPJ3dg0Odg1WcPMPUgjxcAWJuIQ6h3j6-yn4uyn4-3i6-_uFOvu4-od4urgG8zCwpiXmFKfyQmluBmU31xBnD93Ugvz41OKCxOTUvNSS-HB_IwNDCwNDQwMzc0djY-JUAQDVRikd</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>NOVEL PROCESSES FOR THE PRODUCTION OF OLIGONUCLEOTIDES</title><source>esp@cenet</source><creator>TEW, David Graham ; LOVELOCK, Sarah Louise ; SCHOBER, Markus ; CRAMERI, Andreas ; THOMAS, Pamela Joan ; HILL, Malcolm Leithhead</creator><creatorcontrib>TEW, David Graham ; LOVELOCK, Sarah Louise ; SCHOBER, Markus ; CRAMERI, Andreas ; THOMAS, Pamela Joan ; HILL, Malcolm Leithhead</creatorcontrib><description>Disclosed herein are novel processes for the production of oligonucleotides that are suitable for use in the production of chemically modified oligonucleotides, such as those for use in therapy, said processes comprising: a) providing a template oligonucleotide (I) complimentary to the sequence of the product, said template having properties that allow it to be separated from the product; b) providing a pool of oligonucleotides (II); c) contacting (I) and (II) in conditions to allow annealing; d) changing the conditions to separate any impurities, comprising denaturing the annealed template and impurity oligonucleotide strands and separating the impurities; and e) changing the conditions to separate the product, comprising denaturing the annealed template and product oligonucleotide strands and separating the product.
L'invention concerne de nouveaux procédés de production d'oligonucléotides pouvant être utilisés dans la production d'oligonucléotides modifiés chimiquement, tels que ceux utilisés en thérapie.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; DERIVATIVES THEREOF ; ENZYMOLOGY ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; SUGARS ; VINEGAR ; WINE</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180222&DB=EPODOC&CC=WO&NR=2018011067A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180222&DB=EPODOC&CC=WO&NR=2018011067A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TEW, David Graham</creatorcontrib><creatorcontrib>LOVELOCK, Sarah Louise</creatorcontrib><creatorcontrib>SCHOBER, Markus</creatorcontrib><creatorcontrib>CRAMERI, Andreas</creatorcontrib><creatorcontrib>THOMAS, Pamela Joan</creatorcontrib><creatorcontrib>HILL, Malcolm Leithhead</creatorcontrib><title>NOVEL PROCESSES FOR THE PRODUCTION OF OLIGONUCLEOTIDES</title><description>Disclosed herein are novel processes for the production of oligonucleotides that are suitable for use in the production of chemically modified oligonucleotides, such as those for use in therapy, said processes comprising: a) providing a template oligonucleotide (I) complimentary to the sequence of the product, said template having properties that allow it to be separated from the product; b) providing a pool of oligonucleotides (II); c) contacting (I) and (II) in conditions to allow annealing; d) changing the conditions to separate any impurities, comprising denaturing the annealed template and impurity oligonucleotide strands and separating the impurities; and e) changing the conditions to separate the product, comprising denaturing the annealed template and product oligonucleotide strands and separating the product.
L'invention concerne de nouveaux procédés de production d'oligonucléotides pouvant être utilisés dans la production d'oligonucléotides modifiés chimiquement, tels que ceux utilisés en thérapie.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>DERIVATIVES THEREOF</subject><subject>ENZYMOLOGY</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>SUGARS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDDz8w9z9VEICPJ3dg0Odg1WcPMPUgjxcAWJuIQ6h3j6-yn4uyn4-3i6-_uFOvu4-od4urgG8zCwpiXmFKfyQmluBmU31xBnD93Ugvz41OKCxOTUvNSS-HB_IwNDCwNDQwMzc0djY-JUAQDVRikd</recordid><startdate>20180222</startdate><enddate>20180222</enddate><creator>TEW, David Graham</creator><creator>LOVELOCK, Sarah Louise</creator><creator>SCHOBER, Markus</creator><creator>CRAMERI, Andreas</creator><creator>THOMAS, Pamela Joan</creator><creator>HILL, Malcolm Leithhead</creator><scope>EVB</scope></search><sort><creationdate>20180222</creationdate><title>NOVEL PROCESSES FOR THE PRODUCTION OF OLIGONUCLEOTIDES</title><author>TEW, David Graham ; LOVELOCK, Sarah Louise ; SCHOBER, Markus ; CRAMERI, Andreas ; THOMAS, Pamela Joan ; HILL, Malcolm Leithhead</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2018011067A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2018</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>DERIVATIVES THEREOF</topic><topic>ENZYMOLOGY</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>SUGARS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>TEW, David Graham</creatorcontrib><creatorcontrib>LOVELOCK, Sarah Louise</creatorcontrib><creatorcontrib>SCHOBER, Markus</creatorcontrib><creatorcontrib>CRAMERI, Andreas</creatorcontrib><creatorcontrib>THOMAS, Pamela Joan</creatorcontrib><creatorcontrib>HILL, Malcolm Leithhead</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>TEW, David Graham</au><au>LOVELOCK, Sarah Louise</au><au>SCHOBER, Markus</au><au>CRAMERI, Andreas</au><au>THOMAS, Pamela Joan</au><au>HILL, Malcolm Leithhead</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NOVEL PROCESSES FOR THE PRODUCTION OF OLIGONUCLEOTIDES</title><date>2018-02-22</date><risdate>2018</risdate><abstract>Disclosed herein are novel processes for the production of oligonucleotides that are suitable for use in the production of chemically modified oligonucleotides, such as those for use in therapy, said processes comprising: a) providing a template oligonucleotide (I) complimentary to the sequence of the product, said template having properties that allow it to be separated from the product; b) providing a pool of oligonucleotides (II); c) contacting (I) and (II) in conditions to allow annealing; d) changing the conditions to separate any impurities, comprising denaturing the annealed template and impurity oligonucleotide strands and separating the impurities; and e) changing the conditions to separate the product, comprising denaturing the annealed template and product oligonucleotide strands and separating the product.
L'invention concerne de nouveaux procédés de production d'oligonucléotides pouvant être utilisés dans la production d'oligonucléotides modifiés chimiquement, tels que ceux utilisés en thérapie.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre |
| recordid | cdi_epo_espacenet_WO2018011067A3 |
| source | esp@cenet |
| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS VINEGAR WINE |
| title | NOVEL PROCESSES FOR THE PRODUCTION OF OLIGONUCLEOTIDES |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T16%3A44%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=TEW,%20David%20Graham&rft.date=2018-02-22&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EWO2018011067A3%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |