INFILTRATING IMMUNE CELL PROPORTIONS PREDICT ANTI-TNF RESPONSE IN COLON BIOPSIES
Provided are methods of predicting responsiveness of a subject having an inflammatory bowel disease (IBD) to a tumor necrosis factor (TNF)-alpha inhibitor, by analyzing a frequency of at least one subpopulation of immune cells in a tissue biopsy of the subject. Also provided are methods of selecting...
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| creator | STAROVETSKY, Elina VALLANIA, Francesco MAIMON, Naama SHEN-ORR, Shai S GAUJOUX, Renaud KHATRI, Purvesh |
| description | Provided are methods of predicting responsiveness of a subject having an inflammatory bowel disease (IBD) to a tumor necrosis factor (TNF)-alpha inhibitor, by analyzing a frequency of at least one subpopulation of immune cells in a tissue biopsy of the subject. Also provided are methods of selecting a treatment for a subject and kits for determining responsiveness of the subject to treatment with a TNF-alpha inhibitor.
L'invention concerne des procédés de prédiction de la sensibilité d'un sujet ayant une maladie intestinale inflammatoire (IBD) à un inhibiteur du facteur de nécrose tumorale (TNF)-alpha, par analyse d'une fréquence d'au moins une sous-population de cellules immunitaires dans une biopsie de tissu du sujet. L'invention concerne également des procédés de sélection d'un traitement pour un sujet et des kits de détermination de la sensibilité du sujet à un traitement avec un inhibiteur du TNF-alpha. |
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L'invention concerne des procédés de prédiction de la sensibilité d'un sujet ayant une maladie intestinale inflammatoire (IBD) à un inhibiteur du facteur de nécrose tumorale (TNF)-alpha, par analyse d'une fréquence d'au moins une sous-population de cellules immunitaires dans une biopsie de tissu du sujet. L'invention concerne également des procédés de sélection d'un traitement pour un sujet et des kits de détermination de la sensibilité du sujet à un traitement avec un inhibiteur du TNF-alpha.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; ENZYMOLOGY ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; PHYSICS ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171012&DB=EPODOC&CC=WO&NR=2017175228A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171012&DB=EPODOC&CC=WO&NR=2017175228A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>STAROVETSKY, Elina</creatorcontrib><creatorcontrib>VALLANIA, Francesco</creatorcontrib><creatorcontrib>MAIMON, Naama</creatorcontrib><creatorcontrib>SHEN-ORR, Shai S</creatorcontrib><creatorcontrib>GAUJOUX, Renaud</creatorcontrib><creatorcontrib>KHATRI, Purvesh</creatorcontrib><title>INFILTRATING IMMUNE CELL PROPORTIONS PREDICT ANTI-TNF RESPONSE IN COLON BIOPSIES</title><description>Provided are methods of predicting responsiveness of a subject having an inflammatory bowel disease (IBD) to a tumor necrosis factor (TNF)-alpha inhibitor, by analyzing a frequency of at least one subpopulation of immune cells in a tissue biopsy of the subject. Also provided are methods of selecting a treatment for a subject and kits for determining responsiveness of the subject to treatment with a TNF-alpha inhibitor.
L'invention concerne des procédés de prédiction de la sensibilité d'un sujet ayant une maladie intestinale inflammatoire (IBD) à un inhibiteur du facteur de nécrose tumorale (TNF)-alpha, par analyse d'une fréquence d'au moins une sous-population de cellules immunitaires dans une biopsie de tissu du sujet. L'invention concerne également des procédés de sélection d'un traitement pour un sujet et des kits de détermination de la sensibilité du sujet à un traitement avec un inhibiteur du TNF-alpha.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>ENZYMOLOGY</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PHYSICS</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNirEKwjAQQLs4iPoPB84FG5F2rfGiB-ldSE4cS5E4iRbq_2MHP8DpPXhvWQRiR15jq8RnoK67MoJF7yFECRKVhNPseCKr0LJSqewgYgpzQCAGK14YjiQhEaZ1sXgMzylvflwVW4dqL2Ue332exuGeX_nT38TsqrqqD8Y0bbX_7_oCZycwXQ</recordid><startdate>20171012</startdate><enddate>20171012</enddate><creator>STAROVETSKY, Elina</creator><creator>VALLANIA, Francesco</creator><creator>MAIMON, Naama</creator><creator>SHEN-ORR, Shai S</creator><creator>GAUJOUX, Renaud</creator><creator>KHATRI, Purvesh</creator><scope>EVB</scope></search><sort><creationdate>20171012</creationdate><title>INFILTRATING IMMUNE CELL PROPORTIONS PREDICT ANTI-TNF RESPONSE IN COLON BIOPSIES</title><author>STAROVETSKY, Elina ; VALLANIA, Francesco ; MAIMON, Naama ; SHEN-ORR, Shai S ; GAUJOUX, Renaud ; KHATRI, Purvesh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2017175228A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2017</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>ENZYMOLOGY</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PHYSICS</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>STAROVETSKY, Elina</creatorcontrib><creatorcontrib>VALLANIA, Francesco</creatorcontrib><creatorcontrib>MAIMON, Naama</creatorcontrib><creatorcontrib>SHEN-ORR, Shai S</creatorcontrib><creatorcontrib>GAUJOUX, Renaud</creatorcontrib><creatorcontrib>KHATRI, Purvesh</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>STAROVETSKY, Elina</au><au>VALLANIA, Francesco</au><au>MAIMON, Naama</au><au>SHEN-ORR, Shai S</au><au>GAUJOUX, Renaud</au><au>KHATRI, Purvesh</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>INFILTRATING IMMUNE CELL PROPORTIONS PREDICT ANTI-TNF RESPONSE IN COLON BIOPSIES</title><date>2017-10-12</date><risdate>2017</risdate><abstract>Provided are methods of predicting responsiveness of a subject having an inflammatory bowel disease (IBD) to a tumor necrosis factor (TNF)-alpha inhibitor, by analyzing a frequency of at least one subpopulation of immune cells in a tissue biopsy of the subject. Also provided are methods of selecting a treatment for a subject and kits for determining responsiveness of the subject to treatment with a TNF-alpha inhibitor.
L'invention concerne des procédés de prédiction de la sensibilité d'un sujet ayant une maladie intestinale inflammatoire (IBD) à un inhibiteur du facteur de nécrose tumorale (TNF)-alpha, par analyse d'une fréquence d'au moins une sous-population de cellules immunitaires dans une biopsie de tissu du sujet. L'invention concerne également des procédés de sélection d'un traitement pour un sujet et des kits de détermination de la sensibilité du sujet à un traitement avec un inhibiteur du TNF-alpha.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE |
| title | INFILTRATING IMMUNE CELL PROPORTIONS PREDICT ANTI-TNF RESPONSE IN COLON BIOPSIES |
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